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Developmental Neuropathology

  • Reinhard L. Friede

Table of contents

  1. Front Matter
    Pages I-XII
  2. Gross and Microscopic Development of the Central Nervous System

  3. Acquired Lesions in Newborns and Infants

    1. Reinhard L. Friede
      Pages 37-44
    2. Reinhard L. Friede
      Pages 44-51
    3. Reinhard L. Friede
      Pages 51-56
    4. Reinhard L. Friede
      Pages 64-75
    5. Reinhard L. Friede
      Pages 75-85
    6. Reinhard L. Friede
      Pages 122-134
    7. Reinhard L. Friede
      Pages 135-144
    8. Reinhard L. Friede
      Pages 144-149
    9. Reinhard L. Friede
      Pages 150-153
    10. Reinhard L. Friede
      Pages 153-166
    11. Reinhard L. Friede
      Pages 166-178
    12. Reinhard L. Friede
      Pages 187-195
    13. Reinhard L. Friede
      Pages 196-203
    14. Reinhard L. Friede
      Pages 203-214
    15. Reinhard L. Friede
      Pages 214-229
  4. Malformations

    1. Reinhard L. Friede
      Pages 230-240
    2. Reinhard L. Friede
      Pages 240-253
    3. Reinhard L. Friede
      Pages 266-271
    4. Reinhard L. Friede
      Pages 271-279
    5. Reinhard L. Friede
      Pages 280-297
    6. Reinhard L. Friede
      Pages 297-313
    7. Reinhard L. Friede
      Pages 314-326
    8. Reinhard L. Friede
      Pages 326-339
    9. Reinhard L. Friede
      Pages 339-351
    10. Reinhard L. Friede
      Pages 351-357
    11. Reinhard L. Friede
      Pages 357-367
  5. Metabolic Diseases

    1. Reinhard L. Friede
      Pages 368-385
    2. Reinhard L. Friede
      Pages 385-408
    3. Reinhard L. Friede
      Pages 408-423
    4. Reinhard L. Friede
      Pages 433-442
    5. Reinhard L. Friede
      Pages 458-464
    6. Reinhard L. Friede
      Pages 464-475
    7. Reinhard L. Friede
      Pages 488-504
  6. Appendix

  7. Back Matter
    Pages 519-524

About this book

Introduction

The present text was envisioned as a supplement to eXlstmg texts on human neuropathology, covering only those aspects of pediatric neuropathol­ ogy which pertain to and are peculiar of the immature nervous system. No coverage-or only brief comment-is given to diseases commonly found in adults which may, on occasion, occur in childhood or infancy as well. The subject matter is divided into three main categories: 1. The "acquired" lesions dating to the fetal, perinatal or early postnatal periods, 2. the malformations, and 3. the heritable metabolic defects. The first 6 chapters (2-7) are reserved to the lesions most intimately linked to the circumstances of birth. There is some inherent ambiguity in distinguishing between "acquired" lesions and malformations, as, indeed, no sharp distinction can be made between one and the other. Many malformations result from diseases acquired during fetal life and their peculiarity resides in the fact that the organ becomes affected before its development terminates and in such a way that its subsequent development becomes deranged or partly abrogated. A variety of causes acting at the same developmental period or over a common pathogenetic mechanism may produce the same type of derangement, including chemical, physical, infectious or genetic factors, as pointed out repeatedly in the text. Consequently, the definition of a malformation, as differing from an "acquired" residual lesion was made dependant on evidence for the derangement of developmental pro­ cesses subsequent to the acquisition of the disease.

Keywords

neuropathology

Authors and affiliations

  • Reinhard L. Friede
    • 1
    • 2
  1. 1.Case Western Reserve UniversityClevelandUSA
  2. 2.University of ZurichSwitzerland

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