Gross and Microscopic Development of the Central Nervous System

  • Reinhard L. Friede


This chapter concerns mainly the gross and microscopic aspects of normal cerebral development during the second half of gestation, that is the period usually encountered by the pathologist. Its purpose is to provide a frame of reference for assessing normalcy in the brain of the fetus and of the newborn, to point out changes of borderline significance, and to establish base lines for the evaluation of gross or microscopic pathologic changes. The chapter does not provide an extensive review of normal embryology of the human central nervous system; developmental principles are cited only to the extent to which they are of help in interpreting abnormal tissue structure, and pertinent data are generally included in the respective chapters of the text.


White Matter Purkinje Cell Sheath Cell Matrix Cell Matrix Tissue 


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Copyright information

© Springer-Verlag Wien 1975

Authors and Affiliations

  • Reinhard L. Friede
    • 1
    • 2
  1. 1.Case Western Reserve UniversityClevelandUSA
  2. 2.University of ZurichSwitzerland

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