Leptomeningitis in Newborns and Infants

  • Reinhard L. Friede


Scherer (1895) described leptomeningitis in 3 newborns with bacteriologic identification of E. coli as the causative organism. Barron (1918) reviewed 42 cases from early reports on this common disease. The clinico-pathologic features of neonatal leptomeningitis were defined in more detail in the series published by Craig (1936), Watson (1957), Ziai and Haggerty (1958), Groover et al. (1961), Yu and Grauaug (1963), Overall (1970) and others.


Bacterial Meningitis Pneumococcal Meningitis Obstructive Hydrocephalus Epidural Abscess Subdural Empyema 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Adams, R. D., Kubik, C. S., Bonner, F. J.: The clinical and pathological aspects of influenza meningitis. Arch. Pediat. 65: 354–376, 408–441, 1948.PubMedGoogle Scholar
  2. Baker, C. J.: Primary spinal epidural abscess. Amer. J. Dis. Child. 121: 337–339, 1971.PubMedGoogle Scholar
  3. Barber, M., Okubajedo, O. A.: Maternal and neonatal listeriosis: Report of case and brief review of literature of listeriosis in man. Brit. med. J. 2: 735–738, 1965.PubMedGoogle Scholar
  4. Barron, M.: Meningitis in the newborn and in early infancy. Amer. J. med. Sci. 156: 358–369, 1918.CrossRefGoogle Scholar
  5. Berman, P. H., Banker, B. Q.: Neonatal meningitis. A clinical and pathological study of 29 cases. Pediatrics 38: 6–24, 1966.PubMedGoogle Scholar
  6. Bovet-Dubois, N.: Etude anatomoclinique des séquelles d’une méningoencéphalite à l’époque de la naissance. Ann. Pediat. 187: 161–167, 1956.Google Scholar
  7. Buchan, G. C., Alvord, E. C.: Diffuse necrosis of subcortical white matter associated with bacterial meningitis. Neurology (Minneap.) 19: 1–9, 1969.CrossRefGoogle Scholar
  8. Cairns, H., Russell, D. S.: Cerebral arteritis and phlebitis in pneumococcal meningitis. J. Path. Bact. 58: 649–665, 1946.PubMedCrossRefGoogle Scholar
  9. Christensen, E., Husby, J.: Chronic subdural hematoma in infancy. Acta Neurol. Scand. 39: 324–342, 1962.Google Scholar
  10. Courville, C. B.: Subdural empyema secondary to purulent frontal sinusitis. Arch. Otolaryngol. 32: 211–230, 1944.Google Scholar
  11. Courville, C. B.: Birth and Brain Damage. Pasadena, Cal.: M. Farnsworth Courville 1971.Google Scholar
  12. Craig, W. S.: Meningitis in the newborn. Arch. Dis. Child. 11: 171–186, 1936.PubMedCrossRefGoogle Scholar
  13. Crosby, R. M. N., Mosberg, W. H., Smith, G. W.: Intrauterine meningitis as a cause of hydrocephalus. J. Pediat. 52: 94–101, 1958.Google Scholar
  14. Cussen, L., Ryan, B.: Hemorrhagic cerebral necrosis in neonatal infants with enterobacterial meningitis. J. Pediat. 71: 771–776, 1967.PubMedCrossRefGoogle Scholar
  15. De Berranger, P., Decobert, G., Sans, P., Gillot, F.: Hemophilus influenzae meningitis in the newborn. Semaine Hop. 49: 745–754, 1973.Google Scholar
  16. Dooling, E. C., Barlow, J. F., Murphy, J. V., Richardson, E. P.: Cyst of the cavum septi pellucidi. Arch. Neurol. (Chic.) 27: 79–84, 1972.CrossRefGoogle Scholar
  17. Duffy, P. E., Sassin, J. F., Summers, D. S., Lowrie, H.: Rhombencephalitis due to listeria monocytogenes. Neurology (Minneap.) 14: 1067–1072, 1964.CrossRefGoogle Scholar
  18. Eck, H.: Encephalomyelitis listeriaca apostematosa. Schweiz. med. Wschr. 87: 210–214, 1957.PubMedGoogle Scholar
  19. Eicke, W. J.: Gefäßveränderungen bei Meningitis und ihre Bedeutung für die Pathogenese frühkindlicher Hirnschäden. Virchow Arch. 314: 88–124, 1947.CrossRefGoogle Scholar
  20. Epstein, J. A., Goldsier, S. E., II: Bilateral encapsulated subdural effusion complicating bacterial meningitis in infancy. Arch. Neurol. Psychiat. 69: 242–249, 1953.Google Scholar
  21. Farmer, T. W., Wise, G. R.: Subdural empyema in infants, children and adults. Neurology (Minneap.) 23: 254–261, 1973.CrossRefGoogle Scholar
  22. Fitzhardinge, P. M., Kazemi, M., Ramsay, M., Stern, L.: Long-term sequelae of neonatal meningitis. Develop. Med. Child. Neurol. 16: 3–10, 1974.PubMedCrossRefGoogle Scholar
  23. Fothergill, L. D., Wright, J.: Influenzal meningitis. J. Immunol. 24: 273–284. 1933.Google Scholar
  24. Friede, R. L.: Cerebral infarcts complicating neonatal leptomeningitis. Acute and residual lesions. Acta Neuronath 23: 245–253 1973CrossRefGoogle Scholar
  25. Gitlin, D., Rosen, F. S., Michael, J. G.: Transient 19-S gamma globulin deficiency in the newborn infant and its significance. Pediatrics 31: 197–20R, 1963PubMedGoogle Scholar
  26. Groover, R. V., Sutherland, J. M., Landing, B. H.: Purulent meningitis of newborn infants. Eleven-year experience in the antibiotic era. New Engl. J. Med. 264: 1115–1121. 1961.PubMedCrossRefGoogle Scholar
  27. Herzberger, E., Rotem, U., Braham, J.: Remarks on thirty-three cases of subdural effusions in infancy. Arch. Dis. 31 414--50 195AGoogle Scholar
  28. Hirasawa, H.: Morphologischer Beitrag zur Kenntnis der Listeria Meningoencephalitis beim Erwachsenen und Säuglingen. Arch. Psychiat. (Berl.) 197: 449–462, 1958.CrossRefGoogle Scholar
  29. Jenkins, R.: Paraventricular porencephalic diverticulum with latent hemiparesis as a complication of ventriculography. J. Neurol. Neurosurg. Psychiat. 30: 261–263, 1967.PubMedCrossRefGoogle Scholar
  30. Kubik, C. S., Adams, R. D.: Subdural empyema. Brain 66: 18–42, 1943.CrossRefGoogle Scholar
  31. Lu, A. T., Yuen, T. G. H., Bassler, T. J.: Mesencephalic cyst in the fourth ventricle causing obstructive hydrocephalus. Bull. Los Angeles Neurol. Snc 97 79-R6 19A2Google Scholar
  32. McKay, R. J., Ingraham, F. D., Matson, D. D.: Subdural fluid complicating bacterial meningitis. T.A.M.A. 152: 387–391, 1953.Google Scholar
  33. McKay, R. J., Morisette, R. A., Ingraham, F. D., Matson, D. D.: Collections of subdural fluid complicating meningitis due to hemophilus influenzae (Type B). New Engl. J. Med. 242: 20–21, 1950.PubMedCrossRefGoogle Scholar
  34. Malamud, N.: Atlas of Neuropathology, p. 440. Berkley-Los Angeles: Univ. Calif. Press 1957.Google Scholar
  35. Mathies, A. W., Jr., Wehrle, P. F.: Management of bacterial meningitis in children. Pediat. Clin. N. Amer. 15: 185–195, 1968.PubMedGoogle Scholar
  36. Minauf, M., Pateisky, K.: Peculiar white matter lesions associated with purulent meningitis. Acta Neuropath. 18: 262–266, 1971.PubMedCrossRefGoogle Scholar
  37. Munslow, R. A., Stovall, V. S., Price, R. D., Kohler, C. M.: Brain abscess in infants. T. Pediat. 51: 74–79, 1957.Google Scholar
  38. Nicholls, W., Woolley, F. J.: Listeria monocytogenes meningitis. J. Paediat. 61: 337–350, 1962.CrossRefGoogle Scholar
  39. Northfield, D. W. C., Russell, D. S.: False diverticulum of lateral ventricle, causing hemiplegia with chronic internal hydrocephalus. Brain 62: 311–320. 1939.CrossRefGoogle Scholar
  40. Orlandini, O., Sass-Kortsak, A., Ebbs, J. H.: Serum gamma globulin levels in normal infants. Pediatrics 16: 575–583, 1955.PubMedGoogle Scholar
  41. Overall, J. C.: Neonatal bacterial meningitis. J. Pediat. 76: 499–511, 1970.PubMedCrossRefGoogle Scholar
  42. Palmer, J. J., Kelly, W. A.: Epidural abscess in a 3-week-old infant. Pediatrics 50: 817–820. 1972.PubMedGoogle Scholar
  43. Rance, L., Roy, T., Donohue, W., Sepp, A., Elder, R., Finlayson, M.: An epidemic of septicemia with meningitis and hemorrhagic encephalitis in premature infants. J. Pediat. 61: 24–32, 1962.PubMedCrossRefGoogle Scholar
  44. Rappaport, F., Rabinovitz, M., Toaff, R., Krochik, N.: Genital listeriosis as a cause of repeated abortion. Lancet 1: 1273–1275, 1960.PubMedCrossRefGoogle Scholar
  45. Reiss, J. H.: Zur pathologischen Anatomie der frühkindlichen Listeriose. Kinderärztl. Prax. 21: 92–99. 1953.Google Scholar
  46. Rost, H. F., Paul, H., Seelinger, H. P. R.: Habitueller Abort und Listeriose. Dtsch. med. Wschr. 83: 1893–1897, 1958.PubMedCrossRefGoogle Scholar
  47. Russell, D. S.: Observations on the Pathology of Hydrocephalus. London: HMSO 1949.Google Scholar
  48. Saito, M., Gittleman, I. F., Pincus, J. B., Sobel, A. E.: Plasma protein patterns in premature infants of varying weights on the first day of life. Pediatrics 17: 657–662, 1956.PubMedGoogle Scholar
  49. Scherer, F.: Ein Beitrag zur Ätiologie der Leptomeningitis purulenta bei Säuglingen. Jb. Kinderheilk. 39: 1–11, 1895.Google Scholar
  50. Schultz, P., Leeds, N. E.: Intraventricular septations complicating neonatal meningitis. T. Neurosurg. 38: 620–626, 1973.CrossRefGoogle Scholar
  51. Seelinger, H. P. R.: Listeriosis. New York: S. Karger 1961.Google Scholar
  52. Shortland-Webb, W. R.: Proteus and coliform meningocephalitis in neonates. J. clin. Path. 21: 422–431, 1968.PubMedCrossRefGoogle Scholar
  53. Smith, E. S.: Purulent meningitis in infants and children. A review of 409 cases. J. Pediat. 45: 425–436, 1954.PubMedCrossRefGoogle Scholar
  54. Smith, H. V., Norman, R. M., Urich, H.: The late sequelae of pneumococcal meningitis. J. Neurol. Neurosurg. Psychiat. 25: 250–259, 1957.CrossRefGoogle Scholar
  55. Smith, J. F., Landing, B. H.: Mechanisms of brain damage in H. influenzae meningitis. J. Neuropath. exp. Neurol. 19: 248–265, 1960.PubMedCrossRefGoogle Scholar
  56. Smith, M. H. D., Dormont, R. E., Prather, G. W.: Subdural effusions complicating bacterial meningitis. Pediatrics 7: 34–43, 1951.PubMedGoogle Scholar
  57. Stammler, A.: Perivenöse Markdestruktion bei eitriger Meningitis. Dtsch. med. Wschr. 94: 1529–1532, 1969.PubMedCrossRefGoogle Scholar
  58. Vahlquist, B.: Neonatal immunity. Amer. J. Dis. Child. 99: 729–734, 1960.Google Scholar
  59. Watson, D. G.: Purulent neonatal meningitis. A study of fourty-five cases. J. Pediat. 50: 352–360, 1957.PubMedCrossRefGoogle Scholar
  60. Wertham, H.: Cerebral lesions in purulent meningitis. Arch. Neurol. Psychiat. 26: 549–582, 1931.Google Scholar
  61. Williams, J. M., Stevens, H.: Post-meningitic subdural effusions. J. Int. Coll. Surg. Bull. 27: 590–594, 1957.PubMedGoogle Scholar
  62. Yu, J. S., Gr auaug, A.: Purulent meningitis in the neonatal period. Arch. Dis. Child. 38: 391–396, 1963.PubMedCrossRefGoogle Scholar
  63. Ziai, M., Haggerty, R. J.: Neonatal meningitis. New Engl. J. Med. 259: 314–320, 1958.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Wien 1975

Authors and Affiliations

  • Reinhard L. Friede
    • 1
    • 2
  1. 1.Case Western Reserve UniversityClevelandUSA
  2. 2.University of ZurichSwitzerland

Personalised recommendations