Meningoencephalitic Processes in the Perinatal Period

  • Reinhard L. Friede


This chapter concerns types of meningoencephalitis in the newborn that typically develop from intra- or early postpartum infection; a detailed review of these processes was given by Wolf and Cowen (1959). Purulent leptomeningitis of the neonate was covered in the preceding chapter (17) and infections that typically affect the fetus in utero in Chapter 16. The disease processes described in the present chapter occur in children and adults as well, but the text is restricted to their features in early infancy.


Subdural Hematoma Perinatal Period Aseptic Meningitis Coxsackie Virus Chronic Subdural Hematoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Akkoyunlu, A., Yucel, F. A.: Aspergillose broncho-pulmonarie et encéphalo-meningée chez un nouveau-nnd de 20 jours. Arch. franc. Pédiat. 14: 615–622, 1957.PubMedGoogle Scholar
  2. Barsky, P., Beale, A. J.: The transplacental transmission of poliomyelitis. J. Pediat. 51: 207–211, 1957.PubMedCrossRefGoogle Scholar
  3. Baskin, J., Soule, E. H., Mills, S. D.: Poliomyelitis of the newborn. Amer. J. Dis. Child. 80: 10–21, 1950.Google Scholar
  4. Bates, T.: Poliomyelitis in pregnancy, fetus and newborn. Amer. J. Dis. Child. 90: 189–195, 1955.Google Scholar
  5. Bellanti, J. A., Guin, G. H., Grassi, R. M., Olson, L. C.: Herpes simplex encephalitis: Brain hinnsy and treatment with 5-iodlo-2′deoxvuridine. T. Pediat. 72: 266–275, 1968.Google Scholar
  6. Benirschke, K., Raphael, S. L.: Candida albicans infection in the amniotic sac. Amer. J. Obstet. Gynec. 75. 200–202. 1958.PubMedGoogle Scholar
  7. Blattner, R.: Congenital damage to the CNS as a result of intrauterine infection. Comments on current literature. J. Pediat. 52: 620–626, 1958.CrossRefGoogle Scholar
  8. Bruyn, H. B., Lennette, E. H.: Western equine encephalitis in infants, a report on 3 cases with sequelae. Calif. Med. 79: 362–366, 1953.PubMedGoogle Scholar
  9. Burry, A. F.: Hydrocephalus after intrauterine fungal infection. Arch. Dis. Child. 32: 161–163, 1957.PubMedCrossRefGoogle Scholar
  10. De Vita, V. T., Utz, J. P., Williams, T., Carbone, P. P.: Candida meningitis. Arch. intern. Med. (Chic.) 117: 527–535, 1966.Google Scholar
  11. Dobia, B.: Moniliasis in pediatrics. J. Dis. Child. 94, 234–251, 1957.Google Scholar
  12. Eckerberg, B.: A case of prenatal mycosis. Acta Paediat. 50: 317–317, 1961.Google Scholar
  13. Elliott, G. B., McAllister, J. E.: Fetal poliomyelitis. Amer. J. Obstet. Gynec. 72: 896–902, 1956.PubMedGoogle Scholar
  14. Eschwege, J.: Generalized moniliasis with coagulations of the brain. Arch. Neurol. Psychiat. 79: 250–263, 1958.Google Scholar
  15. Farber, S.: Discussion. Amer. J. Dis. Child. 79: 367–368, 1950.Google Scholar
  16. Fechner, R. E., Smith, M. G., Middelkamp, J. N.: Coxsackie B virus infection of the new-born. Amer. J. Path. 42: 493–504, 1963.PubMedGoogle Scholar
  17. Florman, A. L., Mindlin, R. L.: Generalized herpes simplex in an eleven-day-old premature infant. Amer. T. Dis. Child. 83: 481–486, 1952.Google Scholar
  18. France, N. E., Wilmers, M. J.: Herpes-simplex hepatitis and encephalitis in newborn twins. Lancet 1: 1181–1183, 1953.PubMedCrossRefGoogle Scholar
  19. Gaton, E., Gotlieb, A.: A case of aspergillotic meningo-encephalitis in an infant. Beitr. Path. 150: 197–204, 1973.CrossRefGoogle Scholar
  20. Gear, J. H.: Coxsackie virus infections of the newborn. Prog. Med. Virol. 1: 106–121, 1958.PubMedGoogle Scholar
  21. Hass, G.: Hepato-adrenal necrosis with intranuclear inclusion bodies. Amer. J. Path. 11: 127–142, 1935.PubMedGoogle Scholar
  22. Haymaker, W., Smith, M. G., van Bogaert, L., de Chenar, C.: Pathology of viral disease in man characterized by intranuclear inclusions. In: Viral Encephalitis (Fields, W. S., Blattner, R. J., eds.), pp. 95–204. Springfield: Thomas 1958.Google Scholar
  23. Herzberger, E., Rotem, Y., Braham, J.: Remarks on thirty-three cases of subdural effusions in infancy. Arch. Dis. Child. 31: 44–50, 1956.PubMedCrossRefGoogle Scholar
  24. Hosier, D. M., Newton, W. A.: Serious coxsackie infection in infants and children. J. Dis. Child. 96: 251–267, 1958.Google Scholar
  25. Hughesdon, M. R.: Congenital tuberculosis. Arch. Dis. Child. 21: 121–138, 1946.PubMedCrossRefGoogle Scholar
  26. Issel, W.: Ober den Befall des Zentralnervensystems mit Candida albicans. Ärztl. Forsch. 25: 34–43, 1971.PubMedGoogle Scholar
  27. Iyer, S., Dodge, P. R., Adams, R. D.: Two cases of aspergillus infection of the central nervous system. J. Neurol. Neurosurg. Psychiat. 15: 152–163, 1952.PubMedCrossRefGoogle Scholar
  28. Kibrick, S.: The role of coxsackie and ECHO viruses in human disease. Med. Clin. N. Amer. 43: 1291–1308, 1959.PubMedGoogle Scholar
  29. Kibrick, S., Benirschke, K.: Acute aseptic myocarditis and meningoencephalitis in newborn child infected with coxsackie virus Group B, Type 3. New Engl. J. Med. 255: 883–889, 1956.PubMedCrossRefGoogle Scholar
  30. Kibrick, S., Benirschke, K.: Severe generalized disease (encephalohepatomyocarditis) occurring in newborn period and due to infection to coxsackie virus, Group B. Pediatrics 22: 857–874, 1958.PubMedGoogle Scholar
  31. Klein, J. D., Yamauchi, T., Horlick, S. P.: Neonatal candidiasis, meningitis, and arthritis: Observations and a review of the literature. J. Pediat. 81: 31–34, 1972.PubMedCrossRefGoogle Scholar
  32. Landau, J. W., Newcomer, V. D.: Acute cerebral phycomycosis (mucormycosis). Pediatrics 61: 363–385, 1962.CrossRefGoogle Scholar
  33. Lopez, E., Aterman, K.: Intrauterine infection by candida. Amer. J. Dis. Child. 115: 663–670, 1968.PubMedGoogle Scholar
  34. Martin, F. P., Lukeman, J. M., Ranson, R. F., Geppert, L. J.: Mucormycosis of the central nervous system associated with thrombosis of the internal carotid artery. J. Pediat. 44: 437–442, 1954.PubMedCrossRefGoogle Scholar
  35. Medovy, H.: Western equine encephalomyelitis in infants. J. Pediat. 22: 308–318, 1943.CrossRefGoogle Scholar
  36. Moossy, J., Geer, J. C.: Encephalomyelitis, myocarditis, and adrenal cortical necrosis in coxsackie B 3 virus infection: Distribution of the central nervous lesions. Arch. Path. 70: 614–622, 1960.PubMedGoogle Scholar
  37. Mouton, C. M., Smillie, J. G., Bower, A. G.: Report of ten cases of poliomyelitis in infants under six months of age. J. Pediat. 36: 482–492, 1950.CrossRefGoogle Scholar
  38. Neuhauser, E. B. D., Tucker, A.: The Roentgen changes produced by diffuse torulosis in the newborn. Amer. J. Roentgenol. 59: 805–815, 1948.Google Scholar
  39. Nogen, A. G., Lepow, M. L.: Enteroviral meningitis in very young infants. Pediatrics 40: 617–626, 1967.PubMedGoogle Scholar
  40. Noran, H. H., Baker, A. B.: Sequels of equine encephalomyelitis. Arch. Neurol. Psychiat. 49: 398–413, 1943.Google Scholar
  41. Peters, A. H., O’Grady, E., Milanovich, R. A.: Aseptic meningitis associated with echovirus type 3 in very young children. Amer. J. Dis. Child. 123: 452–456, 1962.Google Scholar
  42. Pettay, O., Leinikki, P., Donner, M., Lapinleimu, K.: Herpes simplex virus infection in the newborn. Arch. Dis. Child. 47: 97–103, 1972.PubMedCrossRefGoogle Scholar
  43. Pugh, R. L., Dudgeon, J.: Fatal neonatal poliomyelitis. Arch. Dis. Child. 29: 381–384, 1954.PubMedCrossRefGoogle Scholar
  44. Roessmann, U., Friede, R. L.: Candidal infection of the brain. Arch. Path. 84: 495–498, 1967.PubMedGoogle Scholar
  45. Salter, W., Zinneman, H. H.: Bacteremia and Candida septicemia. Review of 185 cases during a four year period. Minn. Med. 50: 1489–1499, 1967.PubMedGoogle Scholar
  46. Schaeffer, M., Fox, M. J., Li, C. P.: Intrauterine poliomyelitis infection: report of a case. T.A.M.A. 155: 248–250. 1954.Google Scholar
  47. Shinefield, H. R., Townsend, T. E.: Transplacental transmission of Western equine encephalomyelitis. J. Pediat. 43: 21–25, 1953.PubMedCrossRefGoogle Scholar
  48. Smith, L. W., Sano, M. E.: Moniliasis with meningeal involvement. J. infect. Dis. 53: 187–196, 1933.CrossRefGoogle Scholar
  49. Toala, P., Schroeder, S. A., Daly, A. K., Finland, M.: Candida at Boston City Hospital. Arch. intern. Med. (Chic.) 126: 983–989, 1970.Google Scholar
  50. Wagner, J. A., Menon, P. G.: Encephalomalacia in children resulting from tuberculous meningitis and arteritis. The Antiseptic (Madras), p. 323, 1954.Google Scholar
  51. Winter, W. D., Foley, G. E.: Candida infections in children with neoplastic disease. Influence of therapy with antibiotics and steroid hormones. Pediatrics 18: 595–603, 1956.PubMedGoogle Scholar
  52. Wolf, A., Cowen, D.: Perinatal infections of the central nervous system. J. Neuropath. exp. Neurol. 18: 191–242, 1959.PubMedCrossRefGoogle Scholar
  53. Wright, H. T., Okuyama, K., McAllister, R. M.: An infant fatality associated with coxsackie B1 virus. J. Pediat. 63: 428–431, 1963.PubMedCrossRefGoogle Scholar
  54. Young, G. F., Knox, D. L., Dodge, G. R.: Necrotizing encephalitis and chorioretinitis in a young infant. Arch. Neurol. (Chic.) 13: 15–24, 1965.CrossRefGoogle Scholar
  55. Zuelzer, W. W., Stulberg, C. G.: Herpes simplex virus as a cause of fulminating visceral disease and hepatitis in infancy. Amer. J. Dis. Child. 83: 421–439, 1952.Google Scholar

Copyright information

© Springer-Verlag Wien 1975

Authors and Affiliations

  • Reinhard L. Friede
    • 1
    • 2
  1. 1.Case Western Reserve UniversityClevelandUSA
  2. 2.University of ZurichSwitzerland

Personalised recommendations