Porencephaly, Hydranencephaly, Multilocular Cystic Encephalopathy

  • Reinhard L. Friede


Our understanding of the peculiarities of the reactions of immature nervous tissue to destructive lesions originates from the experimental investigations of Spatz (1921) who compared the histopathology of a double transection of the spinal cord in adult and newborn rabbits. The main conclusions of his 318 page report may be summarized as follows: 1. Liquefaction and dissolution of necrotic tissue develops in newborns with exceptional rapidity. Organization of the lesions is essentially completed after 8 days, and the last phagocytes have disappeared by the 12th day. There is little or no proliferation of “fixed” elements and no gliomesodermal scar develops, as organization is mainly carried out by macrophages which disappear rapidly from the lesions. The residual cavity forms a smooth-walled porus. Etiologically different lesions may produce similar residual pori. 2. The reactivity of glial tissue is very limited, in that there is no fibrillary gliosis and development of hypertrophic glial forms is rare. The changes in glial tissue may be interpreted, essentially, as an arrest in its development, particularly in regard to the abrogation of myelination gliosis. The walls of the porus are formed by a thin layer of glial tissue deficient in neurons, but there is no evidence of actual glial scarring.


Basal Ganglion Cerebral Lesion Congenital Toxoplasmosis Glial Tissue Grow Skull Fracture 
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Copyright information

© Springer-Verlag Wien 1975

Authors and Affiliations

  • Reinhard L. Friede
    • 1
    • 2
  1. 1.Case Western Reserve UniversityClevelandUSA
  2. 2.University of ZurichSwitzerland

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