Hemorrhages Characteristic of Asphyxiated Premature Infants

  • Reinhard L. Friede


Intracranial hemorrhages, in particular subependymal, intraventricular and leptomeningeal hemorrhages, are the most common autopsy findings in the brain of asphyxiated premature infants. The incidence of intraventricular hemorrhage has been reported at approximately 1.1 per 1,000 live births (Fedrick and Butler, 1970), but the figure is of limited significance as some degree of subependymal bleeding is extremely common in the newborn succumbing to prematurity. The relationship of these hemorrhages to prematurity was recognized early (Couvelaire, 1903; Ylppö, 1919) and was confirmed in numerous later autopsy series (Hausbrandt and Meier, 1936; Craig, 1939; Gröntoft, 1953, Leech and Kohnen, 1974). Intraventricular hemorrhage also correlates with other factors related to prematurity, such as maternal disease, social factors, primiparity and lower than average birth weight (Fedrick and Butler, 1970; Harcke et al., 1972).


Premature Infant Subarachnoid Hemorrhage Lateral Ventricle Intraventricular Hemorrhage Matrix Tissue 
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Copyright information

© Springer-Verlag Wien 1975

Authors and Affiliations

  • Reinhard L. Friede
    • 1
    • 2
  1. 1.Case Western Reserve UniversityClevelandUSA
  2. 2.University of ZurichSwitzerland

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