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Hemorrhages Characteristic of Asphyxiated Premature Infants

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Developmental Neuropathology

Abstract

Intracranial hemorrhages, in particular subependymal, intraventricular and leptomeningeal hemorrhages, are the most common autopsy findings in the brain of asphyxiated premature infants. The incidence of intraventricular hemorrhage has been reported at approximately 1.1 per 1,000 live births (Fedrick and Butler, 1970), but the figure is of limited significance as some degree of subependymal bleeding is extremely common in the newborn succumbing to prematurity. The relationship of these hemorrhages to prematurity was recognized early (Couvelaire, 1903; Ylppö, 1919) and was confirmed in numerous later autopsy series (Hausbrandt and Meier, 1936; Craig, 1939; Gröntoft, 1953, Leech and Kohnen, 1974). Intraventricular hemorrhage also correlates with other factors related to prematurity, such as maternal disease, social factors, primiparity and lower than average birth weight (Fedrick and Butler, 1970; Harcke et al., 1972).

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References

  • Armstrong, D., Norman, M. G.: Periventricular leucomalacia in neonates: complications and sequelae. Arch. Dis. Child. 49: 367–375, 1974.

    Article  PubMed  CAS  Google Scholar 

  • Bailey, C. J., Windle, W. F.: Neurological, psychological, and neurobiological defects following asphyxia neonatorum in the guinea pig. Exp. Neurol. 1: 467–482, 1959.

    Article  Google Scholar 

  • Claireaux, E. E.: Cerebral pathology of newborns. Guy Hosp. Rep. 108: 2–20, 1959.

    CAS  Google Scholar 

  • Courville, C. B.: Birth and Brain Damage. Pasadena: M. F. Courville 1971.

    Google Scholar 

  • Couvelaire, A.: HĂ©morrhagies du système nerveux central des nouveau-nĂ©s. Ann. Gynec. Obstet. 59: 253–268, 1903.

    Google Scholar 

  • Craig, W. W.: Intracranial hemorrhage in the newborn. Arch. Dis. Child. 13: 89–124, 1938.

    Article  PubMed  CAS  Google Scholar 

  • Dekaban, A., Windle, W. F.: Hemorrhagic lesions in acute birth injuries. J. Neuropath. exp. Neurol. 21: 305–306, 1962.

    Google Scholar 

  • Dyer, N., Brill, A. B., Gutberlat, R., et al.: Timing of intracranial bleeding in newborn infants. J. nuclear Med. 12: 353–354, 1971.

    Google Scholar 

  • Fedrick, J.: Neonatal deaths. Time of death, maturity and lesion. Biol. Neonat. 18: 369–378, 1972.

    Article  Google Scholar 

  • Fedrick, J., Butler, N. R.: Certain causes of neonatal death. II. Intraventricular hemorrhage. Biol. Neonat. 15: 257–290, 1970.

    Article  CAS  Google Scholar 

  • Friede, R. L.: Subpial hemorrhage in infants. J. Neuropath. exp. Neurol. 31: 548–556, 1972.

    Article  PubMed  CAS  Google Scholar 

  • Glaser, J.: The cerebrospinal fluid of premature infants. Amer. J. Dis. Child. 36: 195–247, 1928.

    Google Scholar 

  • Gröntoft, O.: Intracerebral and meningeal haemorrhages in perinatally deceased infants. I. Intracerebral haemorrhages. A pathologico-anatomical and obstetric study. Acta obstet. gynec. scand. 32: 308–333, 1953.

    Article  PubMed  Google Scholar 

  • Gröntoft, O.: Intracerebral and meningeal haemorrhages in perinatally deceased infants. II. Meningeal haemorrhages. A pathologico-anatomical and obstetric study. Acta obstet. gynec. scand. 32: 458–498, 1953.

    Article  PubMed  Google Scholar 

  • Gruenwald, P.: Subependymal cerebral hemorrhage in premature infants and its relation to various injurious influences at birth. Amer. J. Obstet. Gynec. 61: 1285–1292, 1951.

    PubMed  CAS  Google Scholar 

  • Harcke, H. T., Jr., Naeye, R. L., Storch, A., Blanc, W. A.: Perinatal cerebral intraventricular hemorrhage. J. Pediat. 80: 37–42, 1972.

    Article  PubMed  Google Scholar 

  • Harris, L. S., Roessmann, U., Friede, R. L.: Bursting of cerebral ventricular walls. J. Path. Bact. 1: 33–38, 1968.

    Article  Google Scholar 

  • Harrison, V. C., Heese, H., Klein, M.: Intracranial hemorrhage associated with hyaline membrane disease. Arch. Dis. Child. 43: 116–120, 1968.

    Article  PubMed  CAS  Google Scholar 

  • Hausbrandt, F., Meier, A.: Zur Kenntnis der geburtstraumatischen und extrauterin erworbenen Schäden des Zentralnervensystems bei Neugeborenen. Frankfurt. Z. Path. 49: 21–62, 1936.

    Google Scholar 

  • Hemsath, F. A., Canavan, M. M.: Microscopic cerebral hemorrhage in stillbirths and newborn deaths. Amer. J. Obstet. Gynec. 23: 471–478, 1932.

    Google Scholar 

  • Hirvensalo, M.: On hemorrhages of the medulla oblongata and the pons and on respiratory disorders in premature infants. Acta Paediat. (Suppl. 1) 37: 1–112, 1949.

    Article  Google Scholar 

  • Larroche, J.-C.: HĂ©morrhagies cĂ©rĂ©brales intraventriculaires chez le prĂ©mature. Biol. Neonat. 7: 26–56, 1964.

    Article  PubMed  CAS  Google Scholar 

  • Larroche, J.-C.: Post-haemorrhagic hydrocephalus in infancy. Anatomical study. Biol. Neonat. 20: 287–299, 1972.

    Article  CAS  Google Scholar 

  • Larroche, J.-C.: Sub-ependymal pseudocysts in the newborn. Biol. Neonat. 21: 170–183, 1972.

    Article  CAS  Google Scholar 

  • Leech, R. W., Kohnen, P.: Subependymal and intraventricular hemorrhages in the newborn. Am. J. Path. 77: 465–476, 1974.

    PubMed  CAS  Google Scholar 

  • Lorber, J., Bassi, U.: The aetiology of neonatal hydrocephalus. Develop. Med. Child Neurol. 7: 289–294, 1965.

    Article  PubMed  CAS  Google Scholar 

  • Miller, J. A., Jr.: Prevention of brain damage during asphyxia. Proc. 2nd Cong. Int. Asso. Sci. Study Mental Deficiency, Poland, 1970, pp. 444–449.

    Google Scholar 

  • Naeye, R. L., Burt, S., Wright, D. L., Blanc, A., Tatter, D.: Neonatal mortality, the male disadvantage. Pediatrics 48: 902–906, 1971.

    PubMed  CAS  Google Scholar 

  • Noel1, W., Schneider, M.: Ober die Durchblutung und die Sauerstoffversorgung des Gehirns im akuten Sauerstoffmangel. PflĂĽgers Arch. ges. Physiol. 246: 181–249, 1942.

    Article  Google Scholar 

  • Norman, R. M.: Malformations of the nervous system, birth injury and diseases of early life. In: Greenfield’s Neuropathology, Chapter 6, pp. 324–440. E. Arnold 1969.

    Google Scholar 

  • Ranck, J. B., Windle, W. F.: Brain damage in the monkey, Macaca mulatta, by asphyxia neonatorum. Exp. Brain Res. 1: 130–154, 1959.

    Google Scholar 

  • Ross, J. J., Dimmette, R. M.: Subependymal cerebral hemorrhage in infancy. Amer. J. Dis. Child. 110: 531–542, 1965.

    PubMed  CAS  Google Scholar 

  • Ruckensteiner, E., Zöllner, F.: Ăśber die Blutungen im Gebiete der Vena terminalis bei Neugeborenen. Frankfurt. Z. Path. 37: 568–578, 1929.

    Google Scholar 

  • Rydberg, E.: Cerebral injury in newborn children consequent on birth injury. Acta path. scand., Suppl. 10: 1–247, 1932.

    Google Scholar 

  • Schwartz, P.: Erkrankungen des Zentralnervensystems nach traumatischer Geburtsschädigung. Z. Neurol. Psychiat. 90: 263–468, 1924.

    Article  Google Scholar 

  • Schwartz, P.: Die traumatischen Schädigungen des Zentralnervensystems durch die Geburt. Ergebn. inn. Med. Kinderheilk. 31: 165–372, 1927.

    Google Scholar 

  • Schwartz, P., Fink, L.: Morphologie und Entstehung der geburtstraumatischen Blutungen im Gehirn und Schädel des Neugeborenen. Z. Kinderheilk. 40: 427–474, 1925.

    Article  Google Scholar 

  • Siegmund, H.: Die geburtstraumatischen Veränderungen des Zentralnervensystems einschlieĂźlich der Encephalitis congenita. Virchows Handbuch Spec. Path. Anat. Histol. XIII/3: 239–287, 1955.

    Google Scholar 

  • Solcher, H.: Zur Neuroanatomie und Neuropathologie der FrĂĽhfetalzeit. Monogr. Neurol. Psychiat. 127: 1–78. Berlin-Heidelberg-New York: Springer 1968.

    CAS  Google Scholar 

  • Spears, R. L., Hodgman, J. E., Cleland, R. D., Tatter, D., Hanes, B.: Relationship between hyaline membrane disease and intraventricular hemorrhage as cause of death in low birthweight infants. Amer. J. Obstet. Gynec. 105: 1028–1031, 1969.

    PubMed  CAS  Google Scholar 

  • Towbin, A.: Cerebral intraventricular hemorrhage and subependymal matrix infarction in the fetus and premature newborn. Amer. J. Path. 52: 121–139, 1968.

    PubMed  CAS  Google Scholar 

  • Tsiantos, A., Victorin, L., Relier, J. P., et al. :Intracranial hemorrhage in the prematurely born infants. J. Pediat. 85: 854–859, 1974.

    Article  PubMed  CAS  Google Scholar 

  • Windle, W. F.: Cerebral hemorrhage in relation to birth asphyxia. Science 167: 1000–1003, 1970.

    Article  PubMed  CAS  Google Scholar 

  • Ylppö, A.: Pathologisch anatomische Studien bei FrĂĽhgeborenen. Z. Kinderheilk. 20: 212–431, 1919.

    Article  Google Scholar 

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Authors and Affiliations

  1. Case Western Reserve University, Cleveland, Ohio, USA

    Reinhard L. Friede M.D. (Professor of Neuropathology)

  2. University of Zurich, Switzerland

    Reinhard L. Friede M.D. (Professor of Neuropathology)

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  1. Reinhard L. Friede M.D.
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© 1975 Springer-Verlag Wien

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Friede, R.L. (1975). Hemorrhages Characteristic of Asphyxiated Premature Infants. In: Developmental Neuropathology. Springer, Vienna. https://doi.org/10.1007/978-3-7091-3338-5_2

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  • DOI: https://doi.org/10.1007/978-3-7091-3338-5_2

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-7091-3340-8

  • Online ISBN: 978-3-7091-3338-5

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