Thrombosis of Intracranial Sinus and Veins

  • Reinhard L. Friede


There are many clinical and pathologic reports on thrombosis of intracranial sinus and veins in infants in the medical literature of the nineteenth and early twentieth centuries. One of the earliest appears to be that of Gerhardt (1857, 1881) for 7 infants developing venous thrombosis during the first months of life in the course of persistent diarrhea, dehydration and cardiac failure. Parrot (1873) described the pathologic findings in several cases and distinguished clearly the “red softenings” produced by venous thrombosis from the “pale softenings” of periventricular infarcts. Bouchut (1884) reviewed 30 cases and Bertier (1907) found 140 in the literature. Series from 26 to 46 cases reported by Hamburger (1920), Zischinsky (1929); Simpson (1932) and Ebbs (1937) further elaborated on the clinico-pathologic features of the disease. The series of 50 cases reviewed by Byers and Hass (1933) was subsequently enlarged to 80 cases by Bailey and Hass (1937). Since the frequency of the disease has decreased in recent years, these older reports still remain the most comprehensive sources of information. Various classifications of the lesions have been used in these studies; many older reports distinguish only venous thrombosis of noninfectious origin from thrombosis occurring in the course of infectious diseases.


Sinus Thrombosis Superior Sagittal Sinus Cerebral Phlebothrombosis Cerebral Lesion Cerebral Vein 
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Copyright information

© Springer-Verlag Wien 1975

Authors and Affiliations

  • Reinhard L. Friede
    • 1
    • 2
  1. 1.Case Western Reserve UniversityClevelandUSA
  2. 2.University of ZurichSwitzerland

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