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The Guanine — Nucleotide Binding Proteins

Common Structural and Functional Properties

  • Book
  • © 1989

Overview

Editors:
  1. L. Bosch

    1. Leiden University, Leiden, The Netherlands

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  2. B. Kraal

    1. Leiden University, Leiden, The Netherlands

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  3. A. Parmeggiani

    1. Ecole Polytechnique, Palaiseau, France

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Table of contents (39 chapters)

  1. Front Matter

    Pages i-x
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  2. Three-Dimensional Structures and Consensus Sequence Elements

    1. Front Matter

      Pages 1-1
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    2. New Structural Data on Elongation Factor-Tu:Gdp Based on X-Ray Crystallography

      • J. Nyborg, T. la Cour
      Pages 3-14

    3. Progress on the Three-Dimensional Structural Determination of Trypsin-Modified EF-TU-GDP

      • Frances Jurnak, Michelle Nelson, Marilyn Yoder, Susan Heffron, Suet Miu
      Pages 15-25

    4. Three-Dimensional Structure of ras p21 Proteins

      • A. M. de Vos, L. Tong, M. V. Milburn, P. M. Matias, S.-H. Kim
      Pages 27-34

    5. The GTP-Binding Domain Revisited

      • Thomas E. Dever, William C. Merrick
      Pages 35-48

  3. Structure, Function and Genetics of Translational Factors

    1. Front Matter

      Pages 49-49
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    2. Novel Mutants of EF-Tu

      • Diarmaid Hughes, C. G. Kurland
      Pages 51-56

    3. The Elongation Factor EF-Tu FROM E. Coli Activates The tRNA-Tufb Operon in Trans by Binding To A Cis-Acting Region Upstream of The Promoter

      • E. Vijgenboom, L. Nilsson, A. Talens, L. Bosch
      Pages 57-65

    4. Structure-Function Relationships of The Gtp-Binding Domain of Elongation Factor Tu

      • Pieter H. Anborgh, Robbert H. Cool, Eric Jacquet, Michael Jensen, Giuseppe Parlato, Andrea Parmeggiani
      Pages 67-75

    5. A Mutation That Hinders The GTP Induced Aminoacyl-tRNA BINDING of ELONGATION Factor TU

      • Yu-Wen Hwang, Frances Jurnak, David L. Miller
      Pages 77-85

    6. The Application of Fluorescent and Photosensitive Analogues of Guanine Nucleotides to the Function and Structure of G-Binding Proteins

      • J. F. Eccleston, T. F. Kanagasabai, D. P. Molloy, S. E. Neal, M. R. Webb
      Pages 87-97

    7. Affinity Labeling of the GDP/GTP Binding Site in Thermus Thermophilus Elongation Factor Tu

      • Marcus E. Peter, Mathias Sprinzl
      Pages 99-110

    8. Characterization of Elongation Factor Tu from Bacillus Subtilis Modified by Affinity Labelling

      • Jiří Jonák, Karel Karas, Ivan Rychlík
      Pages 111-119

    9. Effects of Kirromycin on the Elongation Factor EF-Tu and its Interactions with GDP or GTP and tRNA. The Application of zone-Interference Gel Electrophoresis, a New Method for the Analysis of Weak Complexes

      • Barend Kraal, Jan Pieter Abrahams, Leendert Bosch
      Pages 121-129

    10. Factors and Ribosomes: Their Coupling and Mode of Signal Processing

      • Wim Möller, Reinout Amons
      Pages 131-142

    11. The Structure and Regulation of Mammalian Initiation Factor eIF2

      • John W. B. Hershey, Vinay K. Pathak, Heidemarie Ernst, Markus Hümbelin, Randal J. Kaufman
      Pages 143-150

  4. Structure, Function and Genetics of ras Proteins

    1. Front Matter

      Pages 151-151
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    2. Structure of the Human ras Gene Family

      • P. Chardin, N. Touchot, A. Zahraoui, V. Pizon, I. Lerosey, B. Olofsson et al.
      Pages 153-163

    3. A Mutational Analysis of ras Function

      • Berthe M. Willumsen, Hedy Adari, Ke Zhang, Alex G. Papageorge, James C. Stone, Frank McCormick et al.
      Pages 165-177
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Keywords

About this book

This volume contains the proceedings of the EMBO-NATO-CEC Advanced Research Workshop on "Guanine-nucleotide binding proteins. Common structural and functional properties", which was held in Renesse, The Netherlands, August 6-11, 1988. The transmission of information is one of the most important processes in cellular life and involves the most diverse physiological functions. The cellular membrane, as the obligatory target for external signals, harbours complex pathways transducing the signals from the receptors of the external stimuli to the cytoplasmic effector. Heterotrimeric proteins are fundamental components of these pathways. Other proteins that are monomeric may be found associated with the membrane or in soluble form in the cytoplasm, and' can also function in signal transduction. Intracellular transmission of signals may proceed in an analogous fashion, protein synthesis being a well-known example. It is one of the most remarkable and puzzling observations of recent years that all of these proteins share common properties, both functionally and structurally. The ir primary structures show pronounced s imilari ties, in most cases concentrated in the NH2-terminal portion of the molecule. They all bind guanine nucleotides (hence the general name of G-proteins) and are GTPases, a crucial enzymatic activity, since it converts the active complex induced by GTP into the inactive one induced by GDP. Consensus sequences have been ident if ied as responsable for interact ing with the different parts of the guanine nucleotide.

Editors and Affiliations

  • Leiden University, Leiden, The Netherlands

    L. Bosch, B. Kraal

  • Ecole Polytechnique, Palaiseau, France

    A. Parmeggiani

Bibliographic Information

  • Book Title: The Guanine — Nucleotide Binding Proteins

  • Book Subtitle: Common Structural and Functional Properties

  • Editors: L. Bosch, B. Kraal, A. Parmeggiani

  • DOI: https://doi.org/10.1007/978-1-4757-2037-2

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 1989

  • Softcover ISBN: 978-1-4757-2039-6Published: 15 April 2013

  • eBook ISBN: 978-1-4757-2037-2Published: 29 June 2013

  • Edition Number: 1

  • Number of Pages: X, 409

  • Number of Illustrations: 93 b/w illustrations

  • Topics: Biochemistry, general

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