Overview
- Editors:
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L. Bosch
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Leiden University, Leiden, The Netherlands
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B. Kraal
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Leiden University, Leiden, The Netherlands
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A. Parmeggiani
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Ecole Polytechnique, Palaiseau, France
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Table of contents (39 chapters)
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Structure, Function and Genetics of ras Proteins
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- Armando Di Donato, Shiv K. Srivastava, Juan Carlos Lacal
Pages 179-190
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- J. B. Gibbs, U. S. Vogel, M. D. Schaber, M. S. Marshall, R. E. Diehl, E. M. Scolnick et al.
Pages 191-200
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- Alan Hall, Jonathan D. H. Morris, Brendan Price, John F. Hancock, Sandra Gardener, Miles D. Houslay et al.
Pages 201-207
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- Jacob John, Mathias Frech, Jürgen Feuerstein, Roger S. Goody, Fred Wittinghofer
Pages 209-214
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- Alfred Pingoud, Uwe Pieper, Roger Busche, Hans-Jürgen Ehbrecht, Matthias Wehrmann, Frank-Ulrich Gast et al.
Pages 215-227
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- Thomas Y. Shih, David J. Clanton, Pothana Saikumar, Linda S. Ulsh, Seisuke Hattori
Pages 229-239
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- Michel Jacquet, Jacques Camonis, Emmanuelle Boy-Marcotte, Faten Damak, Hervé Garreau
Pages 241-249
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- Ottavio Fasano, Jean Bernard Crechet, Emmanuele De Vendittis, Regina Zahn, Georg Feger, Alessandra Vitelli et al.
Pages 251-256
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- Dieter Gallwitz, Heinz Haubruck, Constance Molenaar, Reinhild Prange, Mechthild Puzicha, Hans Dieter Schmitt et al.
Pages 257-264
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- C. D. Reymond, M. E. E. Ludérus, G. N. Europe-Finner, N. A. Thompson, E. Bürki, R. Van Driel et al.
Pages 265-272
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- Klaus Palme, Thomas Diefenthal, Chris Sander, Martin Vingron, Jeff Schell
Pages 273-284
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- B. Guy, M. P. Kieny, Y. Riviere, M. Girard, L. Montagnier, J. P. Lecocq
Pages 285-288
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Structure, Function and Genetics of Signal Transducing Proteins
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Front Matter
Pages 289-289
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- Susan B. Masters, R. Tyler Miller, Kathleen A. Sullivan, Henry R. Bourne
Pages 313-324
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- Michio Ui, Toshiaki Katada
Pages 325-335
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- Yee-Kin Ho, Vijay N. Hingorani
Pages 337-348
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- Ronit Sagi-Eisenberg, Linton M. Traub, Galia Gat-Yablonski, Meir Aridor
Pages 349-357
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About this book
This volume contains the proceedings of the EMBO-NATO-CEC Advanced Research Workshop on "Guanine-nucleotide binding proteins. Common structural and functional properties", which was held in Renesse, The Netherlands, August 6-11, 1988. The transmission of information is one of the most important processes in cellular life and involves the most diverse physiological functions. The cellular membrane, as the obligatory target for external signals, harbours complex pathways transducing the signals from the receptors of the external stimuli to the cytoplasmic effector. Heterotrimeric proteins are fundamental components of these pathways. Other proteins that are monomeric may be found associated with the membrane or in soluble form in the cytoplasm, and' can also function in signal transduction. Intracellular transmission of signals may proceed in an analogous fashion, protein synthesis being a well-known example. It is one of the most remarkable and puzzling observations of recent years that all of these proteins share common properties, both functionally and structurally. The ir primary structures show pronounced s imilari ties, in most cases concentrated in the NH2-terminal portion of the molecule. They all bind guanine nucleotides (hence the general name of G-proteins) and are GTPases, a crucial enzymatic activity, since it converts the active complex induced by GTP into the inactive one induced by GDP. Consensus sequences have been ident if ied as responsable for interact ing with the different parts of the guanine nucleotide.
Editors and Affiliations
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Leiden University, Leiden, The Netherlands
L. Bosch,
B. Kraal
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Ecole Polytechnique, Palaiseau, France
A. Parmeggiani