The Structure and Regulation of Mammalian Initiation Factor eIF2

  • John W. B. Hershey
  • Vinay K. Pathak
  • Heidemarie Ernst
  • Markus Hümbelin
  • Randal J. Kaufman


The process of protein synthesis on ribosomes is promoted by soluble protein factors that act during the initiation, elongation and termination phases of translation (for reviews, see Moldave, 1985; Pain, 1986). A striking characteristic of these factors is that most of them bind GTP or GDP. Since the structure and mechanism of action of these proteins have been studied extensively for the past 20 years, considerable knowledge of their mechanisms of action has accummulated which may be relevant to understanding how G-proteins function in general. We are concerned here with one of the mammalian factors, initiation factor eIF2.


Zinc Finger Motif Eukaryotic Initiation Factor DHFR Gene Guanine Nucleotide Exchange Factor Action Host Cell Protein Synthesis 
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Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • John W. B. Hershey
    • 1
  • Vinay K. Pathak
    • 1
  • Heidemarie Ernst
    • 1
  • Markus Hümbelin
    • 1
  • Randal J. Kaufman
    • 2
  1. 1.Department of Biological Chemistry, School of MedicineUniversity of CaliforniaDavisUSA
  2. 2.Genetics InstituteCambridgeUSA

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