A Mutation That Hinders The GTP Induced Aminoacyl-tRNA BINDING of ELONGATION Factor TU

  • Yu-Wen Hwang
  • Frances Jurnak
  • David L. Miller


Elongation factor Tu (EF-Tu) is a member of the guanine-nucleotide binding protein family. This group of proteins include translational factors1, the ras gene family2, and signal transducing proteins3. Guanine-nucleotide binding proteins exhibit diverse functions but possess common structural elements. Comparing the peptide sequences of these proteins reveals several regions with remarkable amino acid sequence similarity4–6. These regions have been ascribed to the guanine-nucleotide binding domains4–6.


Pyruvate Kinase Guanine Nucleotide Trypsin Digestion Crude Lysate Complex Dissociation 
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Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • Yu-Wen Hwang
    • 1
  • Frances Jurnak
    • 2
  • David L. Miller
    • 1
  1. 1.Molecular Biology DepartmentNYS Institute for Basic ResearchStaten IslandUSA
  2. 2.Department of BiochemistryUniversity of CaliforniaRiversideUSA

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