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Mitochondria in Pathogenesis

  • Book
  • © 2002

Overview

Editors:
  1. John J. Lemasters

    1. University of North Carolina at Chapel Hill, Chapel Hill

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    You can also search for this editor in PubMed   Google Scholar

  2. Anna-Liisa Nieminen

    1. Case Western Reserve University, Cleveland

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    You can also search for this editor in PubMed   Google Scholar

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Table of contents (26 chapters)

  1. Front Matter

    Pages i-xxiii
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  2. Evaluation of Mitochondrial Function in Intact Cells

    1. Front Matter

      Pages 1-1
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    2. Flow Cytometric Analysis of Mitochondrial Function

      • Hagai Rottenberg
      Pages 3-20

    3. Confocal Microscopy of Mitochondrial Function in Living Cells

      • John J. Lemasters, Ting Qian, Donna R. Trollinger, Wayne E. Cascio, Hisayuki Ohata, Anna-Liisa Nieminen
      Pages 21-49

  3. Mitochondrial Disease and Aging

    1. Front Matter

      Pages 51-51
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    2. Primary Disorders of Mitochondrial DNA and the Pathophysiology of mtDNA-Related Disorders

      • Eric A. Schon, Salvatore DiMauro
      Pages 53-80

    3. Transmission and Segregation of Mammalian Mitochondrial DNA

      • Eric A. Shoubridge
      Pages 81-93

    4. Cardiac Reperfusion Injury: Aging, Lipid Peroxidation, and Mitochondrial Function

      • Luke I. Szweda, David T. Lucas, Kenneth M. Humphries, Pamela A. Szweda
      Pages 95-111

  4. Mitochondrial Ion Homeostasis and Necrotic Cell Death

    1. Front Matter

      Pages 113-113
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    2. Ca2+-Induced Transition in Mitochondria: A Cellular Catastrophe?

      • Robert A. Haworth, Douglas R. Hunter
      Pages 115-124

    3. Physiology of the Permeability Transition Pore

      • Mario Zoratti, Francesco Tombola
      Pages 125-152

    4. Control of Mitochondrial Metabolism by Calcium-Dependent Hormones

      • Paul Burnett, Lawrence D. Gaspers, Andrew P. Thomas
      Pages 153-175

    5. The Permeability Transition Pore in Myocardial Ischemia and Reperfusion

      • Andrew P. Halestrap, Paul M. Kerr, Sabzali Javadov, M-Saadah Suleiman
      Pages 177-199

    6. Mitochondrial Calcium Dysregulation during Hypoxic Injury to Cardiac Myocytes

      • Elinor J. Griffiths
      Pages 201-213

    7. Mitochondrial Implication in Cell Death

      • Patrice X. Petit
      Pages 215-246

    8. Role of Mitochondria in Apoptosis Induced by Tumor Necrosis Factor-α

      • Cynthia A. Bradham, Ting Qian, John J. Lemasters, Konrad Streetz, Christian Trautwein, David A. Brenner
      Pages 247-263

    9. The ATP Switch in Apoptosis

      • David J. McConkey
      Pages 265-277

  5. Mitochondria, Free Radicals, and Disease

    1. Front Matter

      Pages 279-279
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    2. Reactive Oxygen Generation by Mitochondria

      • Alicia J. Kowaltowski, Anibal E. Vercesi
      Pages 281-300

    3. Role of the Permeability Transition in Glutamate-Mediated Neuronal Injury

      • Ian J. Reynolds, Teresa G. Hastings
      Pages 301-316
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Keywords

About this book

Mitochondria are organelles in each cell outside the nucleus and are the energy source of all cells. As such, they are crucial to the healthy functioning of cells. Recent research has shown that mitochondrial dysfunction underlies a broad spectrum of disease, from maternally inherited genetic disorders to metabolism defects, aging, stroke, and neurodegenerative diseases such as Parkinson's, Alzheimer's, and Lou Gehrig's disease. This book brings together top researchers whose work in examining the pathophysiologic processes will lead to new strategies for prevention and treatment.

Editors and Affiliations

  • University of North Carolina at Chapel Hill, Chapel Hill

    John J. Lemasters

  • Case Western Reserve University, Cleveland

    Anna-Liisa Nieminen

Bibliographic Information

  • Book Title: Mitochondria in Pathogenesis

  • Editors: John J. Lemasters, Anna-Liisa Nieminen

  • DOI: https://doi.org/10.1007/b114376

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 2002

  • Hardcover ISBN: 978-0-306-46433-1Published: 31 May 2001

  • Softcover ISBN: 978-1-4757-8695-8Published: 23 May 2013

  • eBook ISBN: 978-0-306-46835-3Published: 08 May 2007

  • Edition Number: 1

  • Number of Pages: XXIII, 529

  • Number of Illustrations: 174 b/w illustrations

  • Topics: Cell Biology, Biochemistry, general, Neurology, Internal Medicine

  • Industry Sectors: Biotechnology, Pharma

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