Mitochondria in Pathogenesis

  • John J. Lemasters
  • Anna-Liisa Nieminen

Table of contents

  1. Front Matter
    Pages i-xxiii
  2. Evaluation of Mitochondrial Function in Intact Cells

    1. Front Matter
      Pages 1-1
    2. John J. Lemasters, Ting Qian, Donna R. Trollinger, Wayne E. Cascio, Hisayuki Ohata, Anna-Liisa Nieminen
      Pages 21-49
  3. Mitochondrial Disease and Aging

    1. Front Matter
      Pages 51-51
    2. Luke I. Szweda, David T. Lucas, Kenneth M. Humphries, Pamela A. Szweda
      Pages 95-111
  4. Mitochondrial Ion Homeostasis and Necrotic Cell Death

    1. Front Matter
      Pages 113-113
    2. Robert A. Haworth, Douglas R. Hunter
      Pages 115-124
    3. Mario Zoratti, Francesco Tombola
      Pages 125-152
    4. Paul Burnett, Lawrence D. Gaspers, Andrew P. Thomas
      Pages 153-175
    5. Andrew P. Halestrap, Paul M. Kerr, Sabzali Javadov, M-Saadah Suleiman
      Pages 177-199
    6. Patrice X. Petit
      Pages 215-246
    7. Cynthia A. Bradham, Ting Qian, John J. Lemasters, Konrad Streetz, Christian Trautwein, David A. Brenner
      Pages 247-263
    8. David J. McConkey
      Pages 265-277
  5. Mitochondria, Free Radicals, and Disease

    1. Front Matter
      Pages 279-279
    2. Alicia J. Kowaltowski, Anibal E. Vercesi
      Pages 281-300
    3. Ian J. Reynolds, Teresa G. Hastings
      Pages 301-316
    4. Nickolay Brustovetsky, Janet M. Dubinsky
      Pages 333-340
    5. Anna-Liisa Nieminen, Aaron M. Byrne, Kaisa M. Heiskanen
      Pages 341-359
    6. José C. Fernández-Checa, Carmen García-Ruiz, Anna Colell
      Pages 361-377
    7. Hajimi Higuchi, Hiromasa Ishii
      Pages 379-391
  6. Chemical Toxicity

    1. Front Matter
      Pages 411-411
    2. Gregory J. Gores, James R. Spivey, Ravi Botla, Joong-Won Park, Mark J. Lieser
      Pages 413-423
    3. Lawrence C. Trost, John J. Lemasters
      Pages 425-450
    4. J. Fred Nagelkerke, J. Paul Zoeteweij
      Pages 451-466
    5. Kendall B. Wallace
      Pages 467-488
    6. Dominique Pessayre, Bernard Fromenty, Abdellah Mansouri
      Pages 489-517
  7. Back Matter
    Pages 519-529

About this book


Mitochondria are organelles in each cell outside the nucleus and are the energy source of all cells. As such, they are crucial to the healthy functioning of cells. Recent research has shown that mitochondrial dysfunction underlies a broad spectrum of disease, from maternally inherited genetic disorders to metabolism defects, aging, stroke, and neurodegenerative diseases such as Parkinson's, Alzheimer's, and Lou Gehrig's disease. This book brings together top researchers whose work in examining the pathophysiologic processes will lead to new strategies for prevention and treatment.


ATP Calcium DNA Glutamat Lipid Oxidation Parkinson Purine genetic disorders metabolism

Editors and affiliations

  • John J. Lemasters
    • 1
  • Anna-Liisa Nieminen
    • 2
  1. 1.University of North Carolina at Chapel HillChapel Hill
  2. 2.Case Western Reserve UniversityCleveland

Bibliographic information

Industry Sectors
Health & Hospitals