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Periostin

  • Akira Kudo

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1132)

Table of contents

  1. Front Matter
    Pages i-viii
  2. Overview of Periostin

    1. Front Matter
      Pages 1-1
    2. Akira Kudo
      Pages 3-4
  3. Basic Properties of Periostin

  4. Function as the Scaffold

  5. Health and Disease in Organs

    1. Front Matter
      Pages 33-33
    2. Akira Kudo
      Pages 43-47
    3. Oriane Duchamp de Lageneste, Céline Colnot
      Pages 49-61
    4. Teresa Cobo, Juan L. Cobo, Juan C. Pérez-Varela, José A. Vega, Juan Cobo
      Pages 73-78
    5. Masaki Okamoto, Kenji Izuhara, Shoichiro Ohta, Junya Ono, Tomoaki Hoshino
      Pages 79-87
    6. Darren P. Wallace
      Pages 99-112
    7. Shigeo Yoshida, Yumi Umeno, Masatoshi Haruta
      Pages 113-124
    8. Yingfu Liu, Zhengjie Huang, Dan Cui, Gaoliang Ouyang
      Pages 125-136
  6. Other Types of Fibrosis and Tissue Repair

    1. Front Matter
      Pages 137-137
    2. Akira Kudo
      Pages 139-142
  7. Inflammation

    1. Front Matter
      Pages 143-143
    2. Hisako Matsumoto
      Pages 145-159
  8. Periostin in Development

    1. Front Matter
      Pages 161-161
    2. Athira Suresh, Atreyi Biswas, Saravana Perumal, Satish Khurana
      Pages 163-176
    3. Roger R. Markwald, Ricardo A. Moreno-Rodriguez, Sibnath Ghatak, Suniti Misra, Russell A. Norris, Yukiko Sugi
      Pages 177-191
  9. Biomarker

  10. Clinical Applications

    1. Front Matter
      Pages 205-205
  11. Back Matter
    Pages 211-213

About this book

Introduction

This book provides a comprehensive and up-to-date review of current understanding of periostin and its importance for human health and disease. Periostin is a secretory matricellular protein that has been revealed to play key roles in fibrillogenesis and cell migration, including metastasis of cancer cells. The production of periostin is upregulated during fibrotic responses and the mechanisms by which it promotes fibrosis have become a focus of interest owing to the potential clinical benefit to be derived from periostin blockade. In this book, readers will find coverage of all aspects, from the basic properties of periostin and its function as a scaffold for assembly of extracellular proteins through to its roles in bone and tissue regeneration, tumorigenesis, myocardial infarction, inflammatory and immune system disorders, and other diseases. Readers will also find the latest information on functions of periostin related to stemness and the application of periostin as a biomarker. It is hoped that the detailed knowledge of periostin and its pathobiological significance provided in this book will aid in the search for effective treatments for currently incurable diseases.

Keywords

Periostin Fibrillogenesis Collagen Fibronectin Integrin

Editors and affiliations

  • Akira Kudo
    • 1
  1. 1.International FrontierTokyo Institute of TechnologyTokyoJapan

Bibliographic information

  • DOI https://doi.org/10.1007/978-981-13-6657-4
  • Copyright Information Springer Nature Singapore Pte Ltd. 2019
  • Publisher Name Springer, Singapore
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-981-13-6656-7
  • Online ISBN 978-981-13-6657-4
  • Series Print ISSN 0065-2598
  • Series Online ISSN 2214-8019
  • Buy this book on publisher's site
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