Periostin pp 125-136 | Cite as

The Multiaspect Functions of Periostin in Tumor Progression

  • Yingfu Liu
  • Zhengjie Huang
  • Dan Cui
  • Gaoliang OuyangEmail author
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1132)


Extracellular matrix protein periostin is highly expressed in various tumors and plays a critical role in tumor development and progression. Periostin is mainly secreted by stromal cells such as cancer-associated fibroblasts, myofibroblasts, osteoblasts and bone marrow-derived mesenchymal stromal cells. But in some cases, tumor cells, especially cancer stem cells, can also produce periostin. Periostin has been shown to regulate multiple biological behaviors of tumor cells, including proliferation, survival, invasion, angiogenesis, metastasis and chemoresistance. Moreover, an excessive periostin deposition exerts a pivotal role in remodeling various tumor microenvironments, such as cancer stem cell niche, perivascular niche, premetastatic niche, immunosuppressive microenvironment, bone marrow microenvironment and other tumor growth-supportive microenvironments. In this review, we provide an update understanding of the multifaceted functions and mechanisms of periostin in tumor development and progression.


Periostin Tumor microenvironment Cancer stem cell niche Perivascular niche Premetastatic niche Fibrotic microenvironment Metastatic niche Bone marrow 



This work was supported by grants from the National Natural Science Foundation of China (81572598, 81772616, 31800970) and the Open Research Fund of State Key Laboratory of Cellular Stress Biology, Xiamen University (SKLCSB2017KF007, SKLCSB2016KF004).


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Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Yingfu Liu
    • 1
    • 2
  • Zhengjie Huang
    • 3
  • Dan Cui
    • 2
  • Gaoliang Ouyang
    • 2
    • 4
    Email author
  1. 1.Department of Basic Medical Sciences, Cancer Research Center, School of MedicineXiamen UniversityXiamenChina
  2. 2.State Key Laboratory of Cellular Stress Biology, School of Life SciencesXiamen UniversityXiamenChina
  3. 3.First Affiliated Hospital of Xiamen UniversityXiamen UniversityXiamenChina
  4. 4.Engineering Research Center of Molecular Diagnostics, Ministry of Education, School of Life SciencesXiamen UniversityXiamenChina

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