Periostin pp 23-32 | Cite as

Periostin Functions as a Scaffold for Assembly of Extracellular Proteins

  • Isao KiiEmail author
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1132)


Periostin is a secretory matricellular protein with a multi-domain structure that is composed of an amino-terminal EMI domain, a tandem repeat of four FAS 1 domains, and a carboxyl-terminal domain (CTD). Periostin has been suggested to function as a scaffold for assembly of several extracellular matrix proteins as well as its accessory proteins (Fig. 3.1, Table 3.1), which underlies highly sophisticated extracellular architectures. This scaffold function is likely due to periostin’s multi-domain structure, in which the adjacent domains in periostin interact with different kinds of proteins, put these interacting proteins in close proximity, and promote intermolecular interactions between these proteins, leading to their assembly into a large complex. In this chapter, I introduce the proteins that interact with each of the adjacent domains in periostin, and discuss how the multi-domain structure of periostin functions as a scaffold for the assembly of the interacting proteins, and how it underlies construction of highly sophisticated extracellular architectures.


EMI FAS 1 Heparin Fibronectin Tenascin-C Collagen BMP-1 CCN3 Lysyl oxidase Golgi Endoplasmic reticulum βig-h3 


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© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  1. 1.Laboratory for Pathophysiological and Heath ScienceRIKEN Center for Biosystems Dynamics ResearchChuo-ku, KobeJapan
  2. 2.Compass to Healthy Life Research Complex Program, RIKEN Cluster for Science, Technology and Innovation HubChuo-ku, KobeJapan

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