Periostin pp 43-47 | Cite as

Periostin in Bone Biology

  • Akira KudoEmail author
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1132)


Periostin is specifically expressed in periosteum that functions in bone modeling and remodeling and bone repair, and is sensitive to mechanical stress. Thus periostin has been expected for controlling these crucial systems in bone. The results from periostin deficient mice demonstrate that periostin acts on bone remodeling though detailed mechanisms are unknown. Recent findings have revealed that periostin is essential for bone repair. In this chapter, I introduce expression and function of periostin in bone.


Bone biology Bone repair Mechanical stress Periosteum Fibrillogenesis Collagen cross-linking Lysyl oxidase BMP-1 Fibronectin assembly ECM architecture 



I thank Dr. Kii in Riken for providing the figure.


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Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  1. 1.International FrontierTokyo Institute of TechnologyMeguro-ku, TokyoJapan
  2. 2.School of DentistryShowa UniversityTokyoJapan

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