Molecular Biology of B-Cell and T-Cell Development

  • John G. Monroe
  • Ellen V. Rothenberg

Part of the Contemporary Immunology book series (CONTIM)

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Stem Cells and Lineage Commitment Models

    1. Front Matter
      Pages 1-1
    2. Elaine Dzierzak, Alexander Medvinsky
      Pages 3-25
    3. Peter M. Lansdorp
      Pages 27-40
  3. Intrinsic Factors Regulating B and T Lymphopoiesis

    1. Front Matter
      Pages 55-55
    2. Nicole Avitahl, Aliki Nichogiannopoulou, Katia Georgopoulos, Susan Winandy
      Pages 57-70
    3. Mikael Sigvardsson, Rudolf Grosschedl
      Pages 71-82
    4. Meinrad Busslinger, Stephen L. Nutt
      Pages 83-110
    5. Dimitris Kioussis, Richard Festenstein
      Pages 127-146
  4. Extrinsic Factors Regulating B and T Lymphopoiesis

    1. Front Matter
      Pages 147-147
    2. Tannishtha Reya, Simon R. Carding
      Pages 149-175
    3. Paul W. Kincade, Kay Medina, Glennda Smithson, Zhong Zheng, Kenji Oritani, Lisa Borghesi et al.
      Pages 177-196
    4. Encarnacion Montecino-Rodriguez, Kenneth Dorshkind
      Pages 197-211
    5. Albert Zlotnik, Myriam Capone, Alain P. Vicari
      Pages 213-229
    6. Lisa J. Jarvis, Tucker W. LeBien
      Pages 231-251
  5. Commitment and Ordered Progression in Development of Lymphoid Lineages

    1. Front Matter
      Pages 253-253
    2. Richard R. Hardy, Susan Shinton, Robert Wasserman, Yue-Sheng Li
      Pages 255-266
    3. Barbara L. Kee, Christopher J. Paige
      Pages 267-283
    4. Wu Li, Ferenc Livak, Howard T. Petrie
      Pages 285-303
    5. Koichi Akashi, Motonari Kondo, Annette M. Schlageter, Irving L. Weissman
      Pages 305-336
    6. Ellen V. Rothenberg
      Pages 337-365
    7. Eric S. Hoffman, Lorena Passoni, Erastus C. Dudley, Michael Girardi, Adrian Hayday
      Pages 367-396
  6. Selection Process Operating During B-Lymphocyte Development

    1. Front Matter
      Pages 397-397
    2. Leslie B. King, Peter Sandel, Richard A. Sater, John G. Monroe
      Pages 421-446
  7. Selection Processes Operating During T-Lymphocyte Development

    1. Front Matter
      Pages 447-447
    2. Jan Buer, Harald von Boehmer
      Pages 449-463
  8. Clinical Applications of Hematolymphoid Development

    1. Front Matter
      Pages 503-503
    2. Susan C. Guba, Bart Barlogie
      Pages 505-521
    3. Anne F. Eder, Leslie E. Silberstein
      Pages 523-544
  9. Back Matter
    Pages 573-587

About this book


Despite the tremendous diversity of the cells of the hematopoietic system, they are all derived from common precursor cells that are generated in the fetus and persist into adult life. In this regard, Band T lymphocytes, which comprise the two arms of the antigen-specific and inducible immune system, though functionally very different, are descendants of the same stem cell precursor. In the past several years, we have witnessed an explosion of information regarding the process by which differentiation of B-and T-cells from stem cells occurs. This information, like the answers to most important biological questions, has come from multiple and diverse directions. Because all hematopoietic cells arise from common precursors, complex regulatory processes must be involved in determining commitment to various lineages. Understanding commitment to the B- or T-cell lineage remains incomplete; however, identification of transcription factors necessary for progression along specific B-and T-cell pathways suggests that we are on the verge of understanding the molecules involved in the initial fate-determining steps. Studies of this type previously could be accomplished only in nonmammalian systems that are more amenable to genetic approaches. However, new technologies allow increasingly elegant and informative studies in mammalian systems, particularly for cells of the hematopoietic system.


Chemokine Immune System Ligation Macrophages Termination Transplantation gene therapy genes influence molecular biology molecular mechanisms regulation

Editors and affiliations

  • John G. Monroe
    • 1
  • Ellen V. Rothenberg
    • 2
  1. 1.University of PennsylvaniaPhiladelphiaUSA
  2. 2.California Institute of TechnologyPasadenaUSA

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