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Self-Renewal of Stem Cells

The Intrinsic Timetable Model

  • Chapter
Molecular Biology of B-Cell and T-Cell Development

Part of the book series: Contemporary Immunology ((CONTIM))

Abstract

Most blood cells have a limited life-span, and it is estimated that an adult human needs to produce between 1011 and 1012 mature blood cells per day to compensate for the daily loss of differentiated end cells. Ultimately, this enormous production of cells is derived from a population of hematopoietic stem cells that may need some form of self-renewal to sustain steady-state hematopoiesis and to reconstitute blood cell production following marrow injury.

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Authors
  1. Peter M. Lansdorp
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Editors and Affiliations

  1. University of Pennsylvania, Philadelphia, PA, USA

    John G. Monroe

  2. California Institute of Technology, Pasadena, CA, USA

    Ellen V. Rothenberg

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Lansdorp, P.M. (1998). Self-Renewal of Stem Cells. In: Monroe, J.G., Rothenberg, E.V. (eds) Molecular Biology of B-Cell and T-Cell Development. Contemporary Immunology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4757-2778-4_2

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  • DOI: https://doi.org/10.1007/978-1-4757-2778-4_2

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61737-065-6

  • Online ISBN: 978-1-4757-2778-4

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