Regulation of Lymphocyte Development by Microenvironmental and Systemic Factors

  • Encarnacion Montecino-Rodriguez
  • Kenneth Dorshkind
Chapter
Part of the Contemporary Immunology book series (CONTIM)

Abstract

Lymphocyte development is a dynamic process in which committed lymphoid precursors progress through a series of defined maturational stages before generating B- and T-cells that express immunoglobulin and the T-cell receptor (TCR), respectively (1–4). This process is regulated by a variety of increasingly well-defined extracellular signals that influence the growth and differentiation of developing lymphoid progenitors.

Keywords

Stromal Cell Bone Marrow Stromal Cell Dwarf Mouse Lymphocyte Development Lymphoid Progenitor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Dorshkind, K. (1997) B cell development, in Comprehensive Toxicology (Gleen Sipes, I., Jay Gandolfi, A., and McQueen, C. A., eds.), Elsevier, New York, NY, Vol. 5, 57–76.Google Scholar
  2. 2.
    Godfrey, D. I., Kennedy, J., Suda, T., and Zlotnik, A. (1993) A developmental pathway involving four phenotypically distinct subsets of CD3- CD4- CD8- triple-negative adult mouse thymocytes defined by CD44 and CD25 expression. J. Immunol 150, 4244–4252.PubMedGoogle Scholar
  3. 3.
    Godfrey, D. I. and Zlotnik, A. (1993) Control points in early T cell development. Immunol. Today 14, 547–553.PubMedCrossRefGoogle Scholar
  4. 4.
    Rothenberg, E. V. (1992) The development of functionally responsive T cells. Adv. Immunol 51, 85–214.PubMedCrossRefGoogle Scholar
  5. 5.
    Anderson, G., Moore, N. C., Owen, J. J. T., and Jenkinson, E. J. (1996) Cellular interactions in thymocyte development. Annu. Rev. Immunol 14, 73–100.PubMedCrossRefGoogle Scholar
  6. 6.
    Boyd, R. L., Tucek, C. L., Godfrey, D. I., Izon, D. J., Wilson, T. J., Davidson, N. J., Bean, A. G. D., Ladyman, H. M., Ritter, M. A., and Hugo, P. (1993) The thymic microenvironment. Immunol. Today 14, 445–459.PubMedCrossRefGoogle Scholar
  7. 7.
    Deryugina, E. I. and Muller-Sieburg, C. E. (1993) Stromal cells in long-term cultures: Keys to the elucidation of hematopoietic development? Crit. Rev. Immunol 13, 115–150.PubMedGoogle Scholar
  8. 8.
    Dorshkind K. (1990) Regulation of hemopoiesis by bone marrow stromal cells and their products. Annu. Rev. Immunol 8, 111–137.PubMedCrossRefGoogle Scholar
  9. 9.
    Kincade, P. W., Lee, G., Pietrangeli, C. E., Hayashi, S. I., and Gimble, J. M. (1989) Cells and molecules that regulate B lymphopoiesis in bone marrow. Annu. Rev. Immunol 7, 111–143.PubMedCrossRefGoogle Scholar
  10. 10.
    van Ewjik, W. (1991) T-cell differentiation is influenced by thymic microenvironments. Annu. Rev. Immunol 9, 591–615.CrossRefGoogle Scholar
  11. 11.
    Clark, R. (1997) The somatogenic hormones and insulin-like growth factor-I: Stimulators of lymphopoiesis and immune function. Endocrine Rev. 18, 1–23.CrossRefGoogle Scholar
  12. 12.
    Hooghe-Peters, E. L. and Hooghe, R. (1995) Growth hormone, prolactin, and IGF-I as lymphohemopoietic cytokines, R. G. Lancles, Austin, Tx.Google Scholar
  13. 13.
    Kooijman, R., Hooghe-Peters, E. L., and Hooghe, R. (1996) Prolactin, growth hormone, and insulin-like growth factor-I in the immune system. Adv. Immunol 63, 377–454.PubMedCrossRefGoogle Scholar
  14. 14.
    Whitlock, C. and Witte, O. N. (1982) Long-term culture of B lymphocytes and their precursors from murine bone marrow. Proc. Natl. Acad. Sci. USA 79, 3608–3512.PubMedCrossRefGoogle Scholar
  15. 15.
    Montecino-Rodriguez, E. and Dorshkind, K. (1997) Thymocyte development in vitro: implications for studies of ageing and thymic involution. Mech. Ageing Dev 93, 47–57.PubMedCrossRefGoogle Scholar
  16. 16.
    Montecino-Rodriguez, E. and Dorshkind, K. (1996) Long-term culture of triple negative thymocytes. J. Immunol 156, 957–962.PubMedGoogle Scholar
  17. 17.
    Jenkinson, E. and Owen, J. J. T. (1990) T cell differentiation in thymus organ cultures. Semin. Immunol 16, 12–19.Google Scholar
  18. 18.
    Dorshkind, K., Schouest, L., Fletcher, W. H. (1985) Morphologic analysis of long-term bone marrow cultures that support B-lymphopoiesis or myelopoiesis. Cell Tissue Res. 239, 375–382.PubMedCrossRefGoogle Scholar
  19. 19.
    Kierney, P. C. and Dorshkind, K. (1987) B lymphocyte precursors and myeloid progenitors survive in diffusion chamber cultures but B cell differentiation requires close association with stromal cells. Blood 70, 1418–1424.PubMedGoogle Scholar
  20. 20.
    Lannes-Vicira, J., Dardenne, M., and Savino, W. (1991) Extracellular matrix components of the mouse thymus microenvironment: Ontogenetic studies and modulation by glucocorticoid hormones. J. Histochem. Cytochem 39, 1539–1546.CrossRefGoogle Scholar
  21. 21.
    Le, P. T. and Singer, K. H. (1993) Human thymic epithelial cells: Adhesion molecules and cytokine production. Int. J. Clin. Lab. Res 23, 56–60.PubMedCrossRefGoogle Scholar
  22. 22.
    Oritani, K. and Kincade, P. W. (1996) Identification of stromal cell products that interact with pre-B cells. J. Cell Biol 134, 771–782.PubMedCrossRefGoogle Scholar
  23. 23.
    Patel, D. D. and Haynes, B. F. (1993) Cell adhesion molecules involved in intrathymic T cell development. Sem. Immunol 5, 283–292.CrossRefGoogle Scholar
  24. 24.
    Miyake, K., Underhill, C. B., Lesley, J., and Kincade, P. W. (1990) Hyaluronate can function as a cell adhesion molecule and CD44 participates in hyaluronate recognition. J. Exp. Med 172, 69–75.Google Scholar
  25. 25.
    Kaisho T., Ishikawa, J., Oritami, K., Inazawa, J., Tomizawa, H., Muraoka, O., Ochi, T., and Hirano, T. (1994) BST-1, a surface molecule of bone marrow stromal cell lines that facilitates pre-B-cell growth. Proc. Natl. Acad. Sci. USA 91, 5325–5329.PubMedCrossRefGoogle Scholar
  26. 26.
    Vicari, A. P., Bean, A. G., and Zlotniik, A. (1996) A role for BP-3/BST-1 antigen in early T cell development. Int. Immunol 8, 183–191.PubMedCrossRefGoogle Scholar
  27. 27.
    Kina T., Majumdar, A. S., Heimfeld, S., Kaneshima, H., Holzmann, B., Katsura, Y., and Weissman, I. L. (1991) Identification of a 107 kD glycoprotein that mediates adhesion between stromal cells and hematolymphoid cells. J. Exp. Med 173, 373–381.PubMedCrossRefGoogle Scholar
  28. 28.
    Miyake, K., Medina, K., Ishihara, K., Kimoto, M., Auerbach, R., and Kincade, P. W. (1994) A VCAM like adhesion molecule on murine bone marrow stromal cells mediates binding of lymphocyte precursors in culture. J. Cell. Biol 114, 557–565.CrossRefGoogle Scholar
  29. 29.
    Miyake K., Weissman, I. L., Greenberger, J. S., and Kincade, P. W. (1991) Evidence fora role of the integrin VLA-4 in lympho-hemopoiesis. J. Exp. Med 173, 599–607.Google Scholar
  30. 30.
    Sawada, M., Nagamine, J., Takeda, K., Utsumi, K., Koshugi, A., Tatsumi, Y., Hamaoka, T., Miyake, K., Nakajima, K., Watanabe, T., Sakakibara, S., and Fujiwara, H. (1992) Expression of VLA-4 on thymocytes: maturation state-associated transition and its correlation with their capacity to adhere to thymic stromal cells. J. Immunol 149, 3517–3524.PubMedGoogle Scholar
  31. 31.
    Utsumi, K., Sawada, M., Narumiya, S., Namamine, J., Sakata, T., Iwagami, S., Kita, Y., Teraoka, H., Hirano, H., Ogata, M., Hamaoka, T., and Fujiwara, H. (1991) Adhesion of immature thymocytes to thymic stromal cells through fibronectin molecules and its significance for the induction of thymocyte differentiation. Proc. Natl. Acad. Sci. USA 88, 5685–5689.PubMedCrossRefGoogle Scholar
  32. 32.
    Jacobsen K., Miyake, K., Kincade, P. W., and Osmond, D. G. (1992) Highly restricted expression of a stromal cell determinant in mouse bone marrow in vivo. J. Exp. Med 176, 927–935.PubMedCrossRefGoogle Scholar
  33. 33.
    Boismenu, R., Rhein, M., Fischer, W. H., and Havran, W. L. (1996) A role for CD81 in early T cell development. Science 271, 198–200.PubMedCrossRefGoogle Scholar
  34. 34.
    Baum, L. G., Pang, M., Perillo, N. L., Wu, T., Delegeane, A., Uittenbogaart, C. H., Fukuda, M., and Seilhamer, J. J. (1995) Human thymic epithelial cells express an endogenous lectin, galectin1, which binds to core 2 0-glycans on thymocytes and T lymphoblastoid cells. J. Exp. Med 181, 877–887.PubMedCrossRefGoogle Scholar
  35. 35.
    Muller, K. M., Luedecker, C. J., Udoy, M. C., and Farr, A. G. (1997) Involvement of E-cadherin in thymus organogenesis and thymocyte maturation. Immunity 6, 257–264.PubMedCrossRefGoogle Scholar
  36. 36.
    Arroyo, A. G., Yang, J. T., Rayburn, H., and Hynes, R. O. (1996) Differential requirements for a4 integrins during fetal and adult hematopoiesis. Cell 85, 997–1008.PubMedCrossRefGoogle Scholar
  37. 37.
    Carding, S. R., Hayday, A. C., and Bottomly, K. (1991) Cytokines in T-cell development. Immunol. Today 12, 239–245.PubMedCrossRefGoogle Scholar
  38. 38.
    Dorshkind, K. (1997) Growth and differentiation factors that regulate B lymphocyte development. Weir ‘s Handbook of Experimental Immunology. 5th ed., 81.1–81.12.Google Scholar
  39. 39.
    Marshall, E. and Lord, B. I. (1996) Feedback inhibitors in normal and tumor tissues. Int. Rev. Cytol 167, 185–261.Google Scholar
  40. 40.
    Namen, A. E., Lupton, S., Hjerrild, K., Wagnall, J., Mochizuki, D. Y., Schmierer, A., Mosley, B., March, C., Urdal, D., Gillis, S., Cosman, D., and Goodwin, R. G. (1988) Stimulation of B cell progenitors by cloned murine interleukin-7. Nature 333, 571–573.PubMedCrossRefGoogle Scholar
  41. 41.
    Morrissey, P. J., Goodwin, R. G., Norda, R. P., Anderson, D., Grabstein, K. H., Cosman, D., Sims, J., Lupaton, S., Acres, B., Reed, S. G., Mochizuki, D., Eisenman, J., Conlon, P. J., and Namen, A. E. (1989) Recombinant interleukin-7, pre-B cell growth factor, has costimulatory activity on purified mature T cells. J. Exp. Med 169, 707–716.PubMedCrossRefGoogle Scholar
  42. 42.
    Hardy, R. R., Carmack, C. E., Shinton, S. A., Kemp, J. D., and Hayakawa, K. (1991) Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow. J. Exp. Med 173, 1213–1225.PubMedCrossRefGoogle Scholar
  43. 43.
    Faust, E. A., Saffran, D. C., Toksoz, D., Williams, D. A., and Witte, O. N. (1993) Distinctive growth requirements and gene expression patterns distinguish progenitor B cells from pre-B cells. J. Exp. Med 177, 915–923.PubMedCrossRefGoogle Scholar
  44. 44.
    Henderson, A. J., Narayanan, R., Collins, L., and Dorshkind, K. (1992) Status of kL chain gene rearrangements and c-kit and IL-7 receptor expression in stromal cell-dependent pre-B cells. J. Immunol 149, 1973–1979.PubMedGoogle Scholar
  45. 44a.
    Corcoran, A. E., Smart, F. M., Cowling, R. J., Crompton, T., Owen, M. J., and Venkitaraman, A. R. (1996) The interleukin-7 receptor a chain transmits distinct signals for proliferation and differentiation during B lymphopoiesis. EMBO J. 15, 1924–1932.Google Scholar
  46. 45.
    Moore, T. A. and Zlotnik, A. (1995) T-cell lineage commitment and cytokine responses of thymic progenitors. Blood 86, 1850–1860.PubMedGoogle Scholar
  47. 46.
    Suda, T. and Zlotnik, A. (1991) IL-7 maintains the T cell precursor potential of CD3- CD4CD8- thymocytes. J. Immunol 146, 3068–3073.PubMedGoogle Scholar
  48. 46a.
    von Freeden-Jeffry, U., Solvasson, N., Howard, M., and Murray, R., (1997) The earliest T lineage-committed cells depend on IL-7 for bc1–2 expression and normal cell cycle progression. Immunity 7, 147–154.CrossRefGoogle Scholar
  49. 46b.
    Kondo, M., Akashi, K., Domen, J., Sugamura, K., and Weissman, I. L. (1997) Bc1–2 rescues T lymphopoiesis, but not B or NK cell development, in common y chain-deficient mice. Immunity 7, 155–162.PubMedCrossRefGoogle Scholar
  50. 46c.
    Akashi, K., Kondo, M., von Freeden-Jeffry, U., Murray, R., and Wiessman, I. L. (1997) Bc1–2 rescues T lymphopoiesis in interleukin-7 receptor-deficient mice. Cell 89, 1033–1041.Google Scholar
  51. 46d.
    Maraskovski, E., O’Reilly, L. A., Teepe, M., Corcoran, L. M., Peschon, J. J., and Strasser, A. (1997) Bc1–2 can rescue T lymphocyte development in interleukin-7 receptor-deficient mice but not in mutant rag-1–1- mice. Cell 89, 1011–1019.CrossRefGoogle Scholar
  52. 47.
    Muegge, K., Vila, M., and Dumm, S. (1993) Interleukin 7: a cofactor for V(D)J rearrangement of the T cell receptor gene. Science 261, 923–96.CrossRefGoogle Scholar
  53. 47a.
    Candeias, S., Muegge, K., and Dumm, S. K. (1997) IL-7 receptor and VDJ recombination: trophic versus mechanistic actions. Immunity 6, 501–508.PubMedCrossRefGoogle Scholar
  54. 48.
    Appasamy, P. M., Kenniston, T. W., Weng, Y., Holt, E. C., Kost, J., and Chambers, W. H. (1993) Interleukin-7 induced expression of specific T cell receptor y variable region genes in murine fetal liver cultures. J. Exp. Med 178, 2201–2206.PubMedCrossRefGoogle Scholar
  55. 49.
    Oosterwegel, M. A., Haks, M. C., Jeffry, U., Murray, R., and Kruisbeek, A. M. (1997) Induction of TCR gene rearrangements in uncommitted stem cells by a subset of IL-7 producing, MHC class II-expressing thymic stromal cells. Immunity 6, 351–360.PubMedCrossRefGoogle Scholar
  56. 50.
    Grabstein K. H., Waldschmidt, T. J., Finkelman, F. D., Hess, B. W., Alpert, A. R., Bolani, N. E., Namen, A. E., and Morrissey, P. J. (1993) Inhibition of murine B and T lymphopoiesis in vivo by an anti-interleukin 7 monoclonal antibody. J. Exp. Med 178, 257–264.PubMedCrossRefGoogle Scholar
  57. 51.
    Sudo, T., Nishikawa, S., Ohno, N., Aklyama, N., Tamakoshi, M., Yoshida, H., and Nishikawa, S. (1993) Expression and function of the interleukin 7 receptor in murine lymphocytes. Proc. Natl. Acad. Sci. USA 90, 9125–9129.PubMedCrossRefGoogle Scholar
  58. 52.
    von Freeden-Jeffry, U., Vieira, P., Lucian, L. A., McNeil, T., Burdach, S. E. G., and Murray, R. (1995) Lymphopenia in interleukin (IL)-7, gene-deleted mice identifies IL-7 as a nonredundant cytokine. J. Exp. Med 181, 1519–1526.CrossRefGoogle Scholar
  59. 53.
    Peschon, J. J., Morrissey, P. J., Grabstein, K. H., Ramsdell, F. J., Maraskovsky, E., Gliniak, B. C., Park, L. S., Ziegler, S. F., Williams, D. E., Ware, C. B., Meyer, D., and Davison, B. L. (1994) Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice. J. Exp. Med 180, 1955–1960.Google Scholar
  60. 53a.
    Maraskovsky, E., Teepe, M., Morrissey, P. J., Braddy, S., Miller, R. E., Lynch, D. H., and Peschon, J. J. (1996) Impaired survival and proliferation in IL-7 receptor-deficient peripheral T cells. J. Immunol 157, 5315–5323.PubMedGoogle Scholar
  61. 53b.
    Pribyl, J. A. R. and LeBien, T. W. (1996) Interleukin 7 independent development of human B cells. Proc. Natl. Acad. Sci. USA 93, 10,348–10, 353.Google Scholar
  62. 54.
    Friend, S. L., Hosier, S., Nelson, A., Foxworthe, D., Williams, D. E., and Fan, A. (1994) A thymic stromal cell line supports in vitro development of surface IgM+ B cells and produces a novel growth factor affecting B and T lineage cells. Exp. Hematol 22, 321–328.PubMedGoogle Scholar
  63. 55.
    Ray, R. J., Furlonger, C., Williams, D. E., and Paige, C. J. (1996) Characterization of thymic stromal-derived lymphopoietin (TSLP) in murine B cell development in vitro. Eur. J. Immunol 26, 10–16.PubMedCrossRefGoogle Scholar
  64. 56.
    Palacios, R. G., Henson, G., Steinmetz, M., and McKearn, J. P. (1984) Interleukin-3 supports growth of mouse pre-B cell clones in vitro. Nature 309, 126–131.PubMedCrossRefGoogle Scholar
  65. 57.
    Rennick, D., Jackson, J., Moulds, C., Lee, F., and Yang, G. (1989) IL-3 and stromal cell derived factor synergistically stimulate the growth of pre-B cell lines cloned from long-term lymphoid bone marrow cultures. J. Immunol 142, 161–166.PubMedGoogle Scholar
  66. 58.
    Winkler, T. H., Melchers, F., and Rolink, A. G. (1995) Interleukin-3 and Interleukin-7 are alternative growth factors for the same B-cell precursors in the mouse. Blood 85, 2045–2051.PubMedGoogle Scholar
  67. 59.
    Nagasawa, T., Kikutani, H., and Kishimoto, T. (1994) Molecular cloning and structure of a pre-B cell growth stimulating factor. Proc. Natl. Acad. Sci. USA 91, 2305–2309.Google Scholar
  68. 60.
    Nagasawa, T., Hirota, S., Tachibana, K., Takakura, N., Nishikawa, S., Kitamura, Y., Yoshida, N., Kikutani, H., and Kishimoto, T. (1996) Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1. Nature 382, 635–638.PubMedCrossRefGoogle Scholar
  69. 61.
    Aiuti, A., Webb, I. J., Bleul, C., Springer, T., and Gutierrez-Ramos, J. C. (1997) The chemokine SDF-1 is a chemoattractant for human CD34+ hematopoietic progenitor cells and provides a new mechanisms to explain the mobilization of CD34+ progenitors to peripheral blood. J. Exp. Med 185, 111–120.PubMedCrossRefGoogle Scholar
  70. 62.
    Billips, L. G., Petitte, D., Dorshkind, K., Narayanan, R., Chiu, C. P., and Landreth, K. S. (1992) Differential roles of stromal cells, interleukin-7, and kit-ligand in the regulation of B lymphopoiesis. Blood 79, 1185–1192.PubMedGoogle Scholar
  71. 63.
    Funk, P. E., Varas, A., Witte, P. L. (1993) Activity of stem cell factor and IL-7 in combination on normal bone marrow B lineage cells. J. Immunol 150, 748–752.PubMedGoogle Scholar
  72. 64.
    Godfrey, D I., Zlotnik, A., and Suda, T (1992) Phenotypic and functional characterization of c-kit expression during intrathymic T cell development. J. Immunol 149 2281–2285.Google Scholar
  73. 65.
    McNeice, I. K., Langley, K. E., and Zsebo, K. M. (1991) The role of recombinant stem cell factor in early B cell development. J. Immunol 146, 3785–3790.Google Scholar
  74. 66.
    Ogawa, M., Matsuzaki, Y., Nishikawa, S., Hayashi, S. I., Kunisada, T., Sudo, T., Kina, T., Nakauchi, H., and Nishikawa, S. I. (1991) Expression and function of c-kit in hemopoietic progenitor cells. J. Exp. Med 174, 63–71.PubMedCrossRefGoogle Scholar
  75. 67.
    Rolink, A., Streb, M., Nishikawa, S. I., and Melchers, F. (1991) The c-kit encoded tryrosine kinase regulates the proliferation of early pre-B cells. Eur. J. Immunol 21, 2609–2612.PubMedCrossRefGoogle Scholar
  76. 68.
    Samal, B., Sun, Y., Stearns, G., Xie, C., Suggs, S., and McNiece, I. (1994) Cloning and characterization of the cDNA encoding a novel human pre-B cell-colony enhancing factor. Mol. Cell. Biol 14, 1431–1437.PubMedGoogle Scholar
  77. 69.
    Funk, P., Kincade, P. W., Witte, P. L. (1994) Native associations of early hematopoietic stem cells and stromal cells involved in cell aggregates. Blood 83, 361–369.PubMedGoogle Scholar
  78. 70.
    Gibson, L. F., Piktel, D., and Landreth, K. S. (1993) Insulin like growth factor-I potentiates expansion of interleukin-7 dependent pro-B cells. Blood 82, 3005–3011.PubMedGoogle Scholar
  79. 71.
    Landreth, K. S., Narayanan, R., and Dorshkind, K. (1992) Insulin-like growth factor-I regulates pro-B cell differentiation. Blood 80, 1207–1212.PubMedGoogle Scholar
  80. 72.
    Hirayama, F., Lyman, S. D., Clark, S. C., and Ogawa, M. (1995) The flt3 ligand supports proliferation of lymphohematopoietic progenitors and early B-lymphoid progenitors. Blood 85, 1762–1768.PubMedGoogle Scholar
  81. 73.
    Zuniga-Pflucker, J. C., Jiang, D., and Lenardo, M. (1995) Requirement for TNF-a and IL-la in fetal thymocyte commitment and differentiation. Science 268, 1906–1909.PubMedCrossRefGoogle Scholar
  82. 74.
    Dardenne, M. and Savino, W. (1994) Control of thymus physiology by peptidic hormones and neuropeptides. Immunol. Today 15, 518–523.PubMedCrossRefGoogle Scholar
  83. 75.
    Millington, G. and Buckingham, J. C. (1995) Thymic peptides and neuroendocrine-immune communication. J. Endocrinol 133, 163–168.CrossRefGoogle Scholar
  84. 76.
    Cordero, O. J., Maurer, H. R., and Nogueira, M. (1997) Novel approaches to immunotherapy using thymic peptides. Immunol. Today 18, 10–13.PubMedCrossRefGoogle Scholar
  85. 77.
    Cumano, A., Kee, B. L., Ramsden, D. A., Marshall, A., Paige, C. J., and Wu, G. E. (1994) Development of B lymphocytes from lymphoid committed and uncommitted progenitors. Immunol. Rev 137, 5–33.Google Scholar
  86. 78.
    Kee, B L., Cumano, A., Iscove, N. N., and Paige, C. J. (1994) Stromal cell independent growth of bipotent B cell-macrophage precursors from murine fetal liver. Int. Immunol 6 401–407.Google Scholar
  87. 79.
    Abboud S. L., Bethel C. R., and Aron D. C. (1991) Secretion of insulin-like growth factor I and insulin-like growth factor-binding proteins by murine bone marrow stromal cells. J. Clin. Invest 88, 470–475.PubMedCrossRefGoogle Scholar
  88. 80.
    Hunte, B. E., Hudak, S., Campbell, D., Su, Y., and Rennick, D. (1995) flk2/flt3 ligand is a potent cofactor for the growth of primitive B cell progenitors. J. Immunol 156, 489–496.Google Scholar
  89. 81.
    Mackarehtschian, K., Hardin, J. D., Moore, K. A., Boest, S., Goff, S. P., and Lemischka, I. R. (1995) Targeted disruption of the flk2/flt/3 gene leads to deficiencies in primitive hematopoietic progenitors. Immunity 3, 147–161.Google Scholar
  90. 82.
    Rico-Vargas, S. A., Weiskopf, B., Nishikawa, S., and Osmond, D. G. (1994) c-kit expression by B cell precursors in mouse bone marrow: stimulation of B cell genesis by in vivo treatment with anti-c-kit antibody. J. Immunol 152, 2845–2852.Google Scholar
  91. 83.
    Rodewald, H.-R., Ogawa, M., Haller, C., Waskow, C., and DiSanto, J. P. (1997) Prothymocyte expansion by c-kit and the common cytokine receptor y chain is essential for repertoire formation. Immunity 6, 265–272.PubMedCrossRefGoogle Scholar
  92. 84.
    Dorshkind K. (1988) IL-1 inhibits B cell differentiation in long term bone marrow cultures. J. Immunol 141, 531–538.PubMedGoogle Scholar
  93. 85.
    Hayashi, S. I., Gimble, J. M., Henley, A., Ellingsworth, L. R., and Kincade, P. W. (1989) Differential effects ofTGF-ß on lymphohemopoiesis in long-term bone marrow cultures. Blood 74, 1711–1717.PubMedGoogle Scholar
  94. 86.
    Lee G., Namen, A. E., Gillis, S., Ellingsworth, L. R., and Kincade, P. W. (1989) Normal B cell precursors responsive to recombinant IL-7 and inhibition of IL-7 activity by transforming growth factor-ß. J. Immunol. 142, 3875–3883.PubMedGoogle Scholar
  95. 87.
    Gimble, J. M., Medina, K., Hudson, J., Robinson, M., and Kincade, P. W. (1993) Modulation of lymphohematopoiesis in long-term cultures by gamma interferon: direct and indirect action on lymphoid and stromal cells. Exp. Hematol 21, 224–230.Google Scholar
  96. 88.
    Grawunder U., Melchers, F., and Rolink, A. (1993) Interferon-gamma arrests proliferation and causes apoptosis in stromal cell/interleukin-7-dependent normal murine pre-B cells lines and clones in vitro, but does not induce differentiation to surface immunoglobulin-positive B cells. Eur. J. Immunol 23, 544–551.PubMedCrossRefGoogle Scholar
  97. 89.
    Suda T., Okada, S., Suda, J., et al. (1989) A stimulatory effect of recombinant murine interleukin7 (IL-7) on B cell colony formation and an inhibitory effect of IL-la. Blood 74, 1936–1941.PubMedGoogle Scholar
  98. 90.
    Billips, L. G., Petitte, D., and Landreth, K. S. (1990) Bone marrow stromal cell regulation of B lymphopoiesis: Interleukin-1 (IL-1) and IL-4 regulate stromal cell support of pre-B cell production in vitro. Blood 75, 611–619.PubMedGoogle Scholar
  99. 91.
    King, A., Wierda, D., and Landreth, K. S. (1988) Bone marrow stromal cell regulation of B lymphopoiesis: I. The role of macrophages, interleukin-1, and interleukin-4 in pre-B cell maturation. J. Immunol 141, 2016–2026.PubMedGoogle Scholar
  100. 92.
    Cross, R. J., Bryson, J. S., and Roszman, T. L. (1992) Immunologic disparity in the hypopituitary dwarf mouse. J. Immunol 148, 1347–1352.PubMedGoogle Scholar
  101. 93.
    Fabris, N., Pierpaoli, W., and Sorkin, W. (1971) Hormones and the immunological capacity. III. The immunodeficiency disease of the hypopituitary Snell-bagg dwarf mouse. Clin. Exp. Immunol 9, 209–225.PubMedGoogle Scholar
  102. 94.
    Li, S., Crenshaw 3d, E. B., Rawson, E. J., Simmons, D. M., Swanson, L. W., and Rosenfeld, M. G. (1990) Dwarf locus mutants lacking three pituitary cell types result from mutations in the pou-domain gene pit-1. Nature 347, 528–533.PubMedCrossRefGoogle Scholar
  103. 95.
    Montecino-Rodriguez, E., Clark, R., Powell-Braxton, L., and Dorshkind, K. Primary B cell development is impaired in mice with defects of the pituitary/thyroid axis. J. Immuno1.159,2712–2719.Google Scholar
  104. 96.
    Murphy, W. J., Durum, S. K., Anver, M. R., and Longo, D. L. (1992) Immunologic and hematologic effects of neuroendocrine hormones: studies on Dw/J Dwarf Mice. J. Immunol 148, 3799–3805.PubMedGoogle Scholar
  105. 97.
    Lin, S. C., Lin, C. R., Gukovsky, I., Lusis, A. J., Sawchenko, P. E., and Rosenfeld, M. G. (1993) Molecular basis of the little mouse phenotype and implications for cell type-specific growth. Nature 364, 208–213.PubMedCrossRefGoogle Scholar
  106. 98.
    Powell-Braxton, L., Hollingshead, P., Warburton, C., Dowd, M., Pittes-Meek, S., Dalton, D., Gillett, N., and Stewart, T. A. (1993) IGF-I is required for normal embryonic growth in mice. Genes Dev. 7, 2609–2617.PubMedCrossRefGoogle Scholar
  107. 98a.
    Horseman, N. D., Zhao, W., Montecino-Rodriguez, E., Tanaka, M., Nakashima, K., Engle, S. J., Smith, F., Markoff, E., and Dorshkind, K. (1997) Defective mammopoiesis, but normal hematopoiesis, in mice with a targeted in disruption of the prolactin gene. EMBO J. 16, 6926–6935.CrossRefGoogle Scholar
  108. 99.
    Jardieu, P., Clark, R., Mortensen, D., and Dorshkind, K. (1994) In vivo administration of insulin-like growth factor-1 stimulates primary B lymphopoiesis and enhances lymphocyte recovery after bone marrow transplantation. J. Immunol 152, 4320–4327.PubMedGoogle Scholar
  109. 100.
    Montecino-Rodriguez, E., Clark, R., Johnson, A., Collins, L., and Dorshkind, K. (1996) Defective B cell development in Snell dwarf (dw/dw) mice can be corrected by thyroxine treatment. J. Immunol 157, 3334–3340.PubMedGoogle Scholar
  110. 101.
    Savino, W., Mello-Cohelo, V., and Dardenne, M. (1995) Control of the thymic microenvironment by growth hormone/insulin-like growth factor-I-mediated circuits. Neuroimmunomodulation 2, 313–318.PubMedCrossRefGoogle Scholar
  111. 102.
    Taub, D. D., Tsarfaty, G., Lloyd, A. R., Dumm, S. K., Longo, D. L., and Murphy, W. J. (1994) Growth hormone promotes human T cell adhesion and migration to both human and murine matrix proteins and directly promotes xenogeneic engraftment. J. Clin. Invest 94, 293–300.PubMedCrossRefGoogle Scholar
  112. 103.
    Villa-Verde, D. M. S., De Mello-Cohelo, V., Farias-De-Olivera, D. A., Dardenne, M., and Savino, W. (1993) Pleitropic influence of triiodothyronine on thymus physiology. Endocrinology 133, 867–875.PubMedCrossRefGoogle Scholar
  113. 104.
    Clark, R., Strasser, J., McCabe, S., Robbins, K., and Jardieu, P. (1993) Insulin-like growth factor-I stimulation of lymphopoiesis. J. Clin. Invest 92, 540–548.PubMedCrossRefGoogle Scholar
  114. 105.
    Murphy, W. J., Dumm, S. K., and Longo, D. L. (1993) Differential effects of growth hormone and prolactin on murine T cell development and function. J. Exp. Med 178, 231–236.PubMedCrossRefGoogle Scholar
  115. 106.
    Murphy, W. J., Dumm, S. K., and Longo, D. L. (1992) Role of neuroendocrine hormones in murine T cell development. J. Immunol 149, 3851–3857.PubMedGoogle Scholar
  116. 107.
    Kincade, P. W., Medina, K., and Smithson, G. (1994) Sex hormones as negative regulators of lymphopoiesis. Immunol. Rev 137, 119–134.PubMedCrossRefGoogle Scholar
  117. 108.
    Masuzawa, T, Miyaura, C, Onoe, Y, Kusano, K, Ohta, H., Nozawa, S.C., and Suda, T. (1994) Estrogen deficiency stimulates B lymphopoiesis in mouse bone marrow. J. Clin. Invest 94, 1090–1097.PubMedCrossRefGoogle Scholar
  118. 109.
    Medina, K. L., Kincade, P. W. (1994) Pregnancy-related steroids are potential negative regulators of B lymphopoiesis. Proc. Natl. Acad. Sci. USA 91, 5382–5386.PubMedCrossRefGoogle Scholar
  119. 110.
    Medina, K. L, Smithson, G., Kincade, P. W. (1993) Suppression of B lymphopoiesis during normal pregnancy. J. Exp. Med 178, 1507–1515.PubMedCrossRefGoogle Scholar
  120. 111.
    Smithson, G., Medina, K., Ponting, I., and Kincade, P. W. (1995) Estrogen suppresses stromal cell dependent lymphopoiesis in culture. J. Immunol 155, 3409–3417.PubMedGoogle Scholar
  121. 112.
    Jameson, L. J. and DeGroot, L. J. (1995) Mechanisms of thyroid hormone action, in Endocrinology ( DeGroot, L. J., ed.), W. B. Saunders Co., Philadelphia, pp. 583–616.Google Scholar
  122. 113.
    Gagnerault, M. C., Postel-Vinay, M. C., and Dardenne, M. (1996) Expression of growth hormone receptors in murine lymphoid cells analyzed by flow cytofluorometry. Endocrinology 137, 1719–1726.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • Encarnacion Montecino-Rodriguez
  • Kenneth Dorshkind

There are no affiliations available

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