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Cytokines and Chemokines in T-Cell Development

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Book cover Molecular Biology of B-Cell and T-Cell Development

Part of the book series: Contemporary Immunology ((CONTIM))

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Abstract

The history of T-cell development is highly connected to the physiology of the thymus. Following the pioneering observations of J. F. A. P. Miller on the role of the thymus in T lymphocyte production, many laboratories have studied the events that take place in this gland. As shall be reviewed in this chapter and elsewhere in this book, the events known to take place in the thymus have remained fundamentally unchanged and include: colonization of the thymus by bone-marrow derived precursors; commitment to the T-cell lineage; rearrangement of the TCR genes; selection of T-cells according to their MHC and antigenic specificity, and finally, export from the thymus to the periphery. However, new molecular insights obtained more recently have reaffirmed these events. During the 1980s, the main interest of most T-cell development labs focused on the selection mechanisms that resulted in the T-cell repertoire. This was prompted by the molecular characterization of the T-cell receptor, as well as the availability of reagents (monoclonal antibodies, and so forth), which allowed the demonstration of positive and negative selection. Only a few labs focused instead on the earlier events of T-cell development, before positive and negative selection take place. More recently, this situation has changed with more labs studying the early events of T-cell development in the thymus. We have really only begun to understand the basic events that take place before the CD4+CD8+ (double positive [DP]) stage. This situation means that many basic and important developments await to be discovered and understood in early T-cell development.

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Authors
  1. Albert Zlotnik
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  2. Myriam Capone
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  3. Alain P. Vicari
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Editor information

Editors and Affiliations

  1. University of Pennsylvania, Philadelphia, PA, USA

    John G. Monroe

  2. California Institute of Technology, Pasadena, CA, USA

    Ellen V. Rothenberg

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Zlotnik, A., Capone, M., Vicari, A.P. (1998). Cytokines and Chemokines in T-Cell Development. In: Monroe, J.G., Rothenberg, E.V. (eds) Molecular Biology of B-Cell and T-Cell Development. Contemporary Immunology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4757-2778-4_12

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  • DOI: https://doi.org/10.1007/978-1-4757-2778-4_12

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61737-065-6

  • Online ISBN: 978-1-4757-2778-4

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