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Lineage Relationships Between B Lymphocytes and Macrophages

  • Barbara L. Kee
  • Christopher J. Paige
Chapter
Part of the Contemporary Immunology book series (CONTIM)

Abstract

B lymphocytes, like all members of the hematopoietic system, develop from a common hematopoietic stem cell (HSC) in the bone marrow and fetal liver (1). Restricted stem cells, apparently able to give rise to myeloid lineage cells but not to B and T lymphocytes, have also been identified (2,3). However, lymphoid restricted stem cells have proven more difficult to identify conclusively, despite widespread belief that they exist (see refs. 4 and 5). The development of hematopoietic cells committed to a single lineage is thought to occur through the progressive restriction of the differentiation options of multipotent progenitors. For example, multipotent myeloid stem cells develop into nonself-renewing progenitors that give rise to granulocytes, erythrocytes, macrophages, and megakaryocytes (GEMM progenitors) and subsequently into granulocytes and macrophages (GM progenitors) under conditions that support the development of all myeloid cell types (6). Recently, bipotent progenitors, which develop into both B lymphocytes and macrophages, have been identified in the fetal liver of mice by the twelfth day of gestation (Fig. 1) (7).

Keywords

Hematopoietic Stem Cell Fetal Liver Stem Cell Factor Murine Bone Marrow Lineage Determination 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer Science+Business Media New York 1998

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  • Barbara L. Kee
  • Christopher J. Paige

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