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  • Book
  • © 2008

Cyclin Dependent Kinase 5 (Cdk5)

  • Will appeal to researchers from various fields of neuroscience research, in light of the extensive involvement of Cdk5 in neuronal development, plasticity and neurological disorders

  • Written by leaders in the field of Cdk5 research

  • Will encompass a variety of Cdk5 studies using different approaches to elucidate the functions and signaling mechanisms of Cdk5

Buying options

eBook USD 149.00
Price excludes VAT (USA)
  • ISBN: 978-0-387-78887-6
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
Softcover Book USD 199.99
Price excludes VAT (USA)
Hardcover Book USD 199.99
Price excludes VAT (USA)

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Table of contents (18 chapters)

  1. Front Matter

    Pages i-xvi
  2. Cdk5/p35 Regulates Neuronal Migration

    • Toshio Ohshima
    Pages 1-8
  3. CRMP Family Protein: Novel Targets for Cdk5 That Regulates Axon Guidance, Synapse Maturation, and Cell Migration

    • Yoshio Goshima, Yukio Sasaki, Yutaka Uchida, Naoya Yamashita, Fumio Nakamura
    Pages 9-24
  4. Cdk5 in Presynapses

    • Fan-Yan Wei, Kazuhito Tomizawa
    Pages 25-33
  5. Cyclin-Dependent Kinase 5 (Cdk5) Modulates Signal Transduction Pathways Regulating Neuronal Survival

    • Parvathi Rudrabhatla, Jyotshna Kanungo, Ya-Li Zheng, Niranjana D. Amin, Sashi Kesavapany, Harish C. Pant
    Pages 69-90
  6. CDK5 and Mitochondrial Cell Death Pathways

    • Katrin Meuer, Mathias Bähr, Jochen H. Weishaupt
    Pages 91-106
  7. Regulation and Function of Cdk5 in the Nucleus

    • Qian Yang, Zixu Mao
    Pages 107-118
  8. Cdk5 May Be an Atypical Kinase, but Not in the Way You Think

    • Li Wang, Jie Zhang, Karl Herrup
    Pages 119-137
  9. Cdk5 and Neuregulin-1 Signaling

    • Yi Wen, Haung Yu, Karen Duff
    Pages 139-144
  10. Cyclin-Dependent Kinase 5 and Insulin Secretion

    • Christina Bark, Marjan Rupnik, Marko Jevsek, Slavena A. Mandic, Per-Olof Berggren
    Pages 145-158
  11. Protein–Protein Interactions Involving the N-Terminus of p35

    • Gary Kar Ho Ng, Lisheng He, Robert Z. Qi
    Pages 159-170
  12. The Kinase Activity of Cdk5 and Its Regulation

    • Shin-ichi Hisanaga, Koichi Ishiguro
    Pages 171-190
  13. The Structural Bases of CDK5 Activity

    • Andrea Musacchio
    Pages 191-210
  14. Cdk5, a Journey from Brain to Pain: Lessons from Gene Targeting

    • Tej K. Pareek, Ashok B. Kulkarni
    Pages 211-226
  15. Involvement of Cdk5 in Synaptic Plasticity, and Learning and Memory

    • Florian Plattner, K. Peter Giese, Marco Angelo
    Pages 227-260
  16. Cdk5 as a Drug Target for Alzheimer’s Disease

    • Lit-Fui Lau, Carol D. Hicks
    Pages 283-299
  17. Back Matter

    Pages 301-329

About this book

Cyclin Dependent Kinase 5 provides a comprehensive and up-to-date collection of reviews on the discovery, signaling mechanisms and functions of Cdk5, as well as the potential implication of Cdk5 in the treatment of neurodegenerative diseases. Since the identification of this unique member of the Cdk family, Cdk5 has emerged as one of the most important signal transduction mediators in the development, maintenance and fine-tuning of neuronal functions and networking. Further studies have revealed that Cdk5 is also associated with the regulation of neuronal survival during development as well as in neurodegenerative diseases. These observations indicate that precise control of Cdk5 is essential for the regulation of neuronal survival. The pivotal role that Cdk5 appears to play in both the regulation of neuronal survival and synaptic functions thus raises the interesting possibility that Cdk5 inhibitors may have therapeutic potential for the treatment of a number of neurodegenerative diseases.

Keywords

  • Alzheimer
  • Cdk5
  • Neuron
  • genes
  • migration
  • neurodegenerative diseases
  • proteins
  • regulation
  • signal transduction
  • synaptic plasticity

Bibliographic Information

Buying options

eBook USD 149.00
Price excludes VAT (USA)
  • ISBN: 978-0-387-78887-6
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
Softcover Book USD 199.99
Price excludes VAT (USA)
Hardcover Book USD 199.99
Price excludes VAT (USA)