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CDK5 and Mitochondrial Cell Death Pathways

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Cyclin Dependent Kinase 5 (Cdk5)

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Abstract

Programmed cell death (PCD) or apoptosis is regarded as an evolutionary conserved program that physiologically controls cell number and morphology of multicellular organisms during development. The same apoptotic machinery can be reactivated in the adult organism under disease conditions. Mitochondria play a central role in many apoptotic cascades, both as a storage place for pro-apoptotic molecules and for the production of ATP that is required for apoptosis. Moreover, mitochondria can acquire a broad range of morphologies, and mitochondrial fission has been shown to be a necessary step in early apoptosis. In recent years, abundant evidence accumulated that cyclin-dependent kinase 5 (CDK5) is an important death-promoting kinase in neurodegeneration. However, it remained unclear for a long time where to integrate CDK5 into the established apoptosis pathways. In this book chapter, we review the involvement of CDK5 in mitochondrial cell death pathways, with special emphasis on the aspect of mitochondrial morphology during neuronal apoptosis.

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Authors and Affiliations

  1. Department of Neurology, University of Göttingen, Robert-Koch-Str. 40, 37075 Göttingen, Germany

    Jochen H. Weishaupt

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  1. Katrin Meuer
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  2. Mathias Bähr
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  3. Jochen H. Weishaupt
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Correspondence to Jochen H. Weishaupt .

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Editors and Affiliations

  1. Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China

    Nancy Y. Ip

  2. Department of Brain and Cognitive Science, Howard Hughes Medical Institute, Massachusetts Institute of Technology, 77 Massachusetts Avenue, 02139, Cambridge, MA, USA

    Li-Huei Tsai

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Meuer, K., Bähr, M., Weishaupt, J.H. (2008). CDK5 and Mitochondrial Cell Death Pathways. In: Ip, N.Y., Tsai, LH. (eds) Cyclin Dependent Kinase 5 (Cdk5). Springer, Boston, MA. https://doi.org/10.1007/978-0-387-78887-6_7

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