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CDK5 and Mitochondrial Cell Death Pathways

  • Katrin Meuer
  • Mathias Bähr
  • Jochen H. Weishaupt
Chapter

Abstract

Programmed cell death (PCD) or apoptosis is regarded as an evolutionary conserved program that physiologically controls cell number and morphology of multicellular organisms during development. The same apoptotic machinery can be reactivated in the adult organism under disease conditions. Mitochondria play a central role in many apoptotic cascades, both as a storage place for pro-apoptotic molecules and for the production of ATP that is required for apoptosis. Moreover, mitochondria can acquire a broad range of morphologies, and mitochondrial fission has been shown to be a necessary step in early apoptosis. In recent years, abundant evidence accumulated that cyclin-dependent kinase 5 (CDK5) is an important death-promoting kinase in neurodegeneration. However, it remained unclear for a long time where to integrate CDK5 into the established apoptosis pathways. In this book chapter, we review the involvement of CDK5 in mitochondrial cell death pathways, with special emphasis on the aspect of mitochondrial morphology during neuronal apoptosis.

Keywords

CDK5 Inhibition Mitochondrial Fission CDK5 Activity Mitochondrial Morphology Mitochondrial Fusion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Katrin Meuer
  • Mathias Bähr
  • Jochen H. Weishaupt
    • 1
  1. 1.Department of NeurologyUniversity of GöttingenGermany

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