Cyclin-Dependent Kinase 5: A Critical Regulator of Neurotransmitter Release

  • Sul-Hee Chung


Neurotransmitter release is tightly regulated through the specific control of the synaptic vesicle cycle, which is composed of Ca++-triggered exocytosis, endocytosis, and recycling. Various protein kinases have been implicated in the regulation of neurotransmitter release. Accumulating evidence indicates that cyclin-dependent kinase 5 (Cdk5) controls the multiple steps of neurotransmitter release through phosphorylation of the various substrates involved in synaptic vesicle exocytosis, endocytosis, neurotransmitter synthesis, Ca++ influx, and lipid signaling at presynaptic terminals—the distal ends of axons that specialize in neurotransmitter release. This study is an overview of the most recent information available concerning Cdk5-mediated phosphorylation as a critical regulatory mechanism for neurotransmitter release at presynaptic terminals.


PC12 Cell Tyrosine Hydroxylase Synaptic Vesicle Neurotransmitter Release Presynaptic Terminal 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



This work was supported by KOSEF (R01-2007-000-11910-0) funded by the Korean government (MOST). This work was also supported by a Korea Research Foundation grant funded by the Korean Government (MOEHRD) (KRF-2007-331-E00198) and by the IBST Grant 2006 and 2007 from Inje University. Due to space limitation, the author regrets not being able to cite all relevant publications in this review.


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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  1. 1.Graduate Program in NeuroscienceInstitute for Brain Science and Technology, Inje UniversityBusanjin-guSouth Korea

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