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Cyclin-Dependent Kinase 5: A Critical Regulator of Neurotransmitter Release

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Book cover Cyclin Dependent Kinase 5 (Cdk5)

Abstract

Neurotransmitter release is tightly regulated through the specific control of the synaptic vesicle cycle, which is composed of Ca++-triggered exocytosis, endocytosis, and recycling. Various protein kinases have been implicated in the regulation of neurotransmitter release. Accumulating evidence indicates that cyclin-dependent kinase 5 (Cdk5) controls the multiple steps of neurotransmitter release through phosphorylation of the various substrates involved in synaptic vesicle exocytosis, endocytosis, neurotransmitter synthesis, Ca++ influx, and lipid signaling at presynaptic terminals—the distal ends of axons that specialize in neurotransmitter release. This study is an overview of the most recent information available concerning Cdk5-mediated phosphorylation as a critical regulatory mechanism for neurotransmitter release at presynaptic terminals.

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Acknowledgments

This work was supported by KOSEF (R01-2007-000-11910-0) funded by the Korean government (MOST). This work was also supported by a Korea Research Foundation grant funded by the Korean Government (MOEHRD) (KRF-2007-331-E00198) and by the IBST Grant 2006 and 2007 from Inje University. Due to space limitation, the author regrets not being able to cite all relevant publications in this review.

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  1. Graduate Program in Neuroscience, Institute for Brain Science and Technology, Inje University, 633-146 Gaegeum 2-dong, 614-735, Busanjin-gu, Busan, South Korea

    Sul-Hee Chung

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  1. Sul-Hee Chung
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Correspondence to Sul-Hee Chung .

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Editors and Affiliations

  1. Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China

    Nancy Y. Ip

  2. Department of Brain and Cognitive Science, Howard Hughes Medical Institute, Massachusetts Institute of Technology, 77 Massachusetts Avenue, 02139, Cambridge, MA, USA

    Li-Huei Tsai

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Chung, SH. (2008). Cyclin-Dependent Kinase 5: A Critical Regulator of Neurotransmitter Release. In: Ip, N.Y., Tsai, LH. (eds) Cyclin Dependent Kinase 5 (Cdk5). Springer, Boston, MA. https://doi.org/10.1007/978-0-387-78887-6_4

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