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Regulation and Function of Cdk5 in the Nucleus

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Cyclin Dependent Kinase 5 (Cdk5)

Abstract

Early studies have shown that Cyclin-dependent kinase 5 (Cdk5) and its regulators function in the neuronal cytoplasm to regulate a range of cellular processes. This seems to distinct Cdk5 from other more traditional Cdks. However, recent discoveries have now extended the role of Cdk5 to the nucleus. This chapter summarizes these novel findings. These include the detection of Cdk5 and its regulators in the nucleus, identification of nuclear targets of Cdk5, and regulation of nuclear Cdk5 and its activators.

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Acknowledgements

The authors apologize for not being able to cite all the relevant studies due to space limitation. This work is supported by NIH AG023695, NS048254, and ES0153170, and by the Robert W. Woodruff Health Sciences Center Fund (Z.M).

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Authors and Affiliations

  1. Departments of Pharmacology and Neurology, Center for Neurodegenerative Disease, Emory University School of Medicine, 615 Michael St, Atlanta, GA 30322, USA

    Zixu Mao

Authors
  1. Qian Yang
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  2. Zixu Mao
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Correspondence to Zixu Mao .

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Editors and Affiliations

  1. Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China

    Nancy Y. Ip

  2. Department of Brain and Cognitive Science, Howard Hughes Medical Institute, Massachusetts Institute of Technology, 77 Massachusetts Avenue, 02139, Cambridge, MA, USA

    Li-Huei Tsai

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Yang, Q., Mao, Z. (2008). Regulation and Function of Cdk5 in the Nucleus. In: Ip, N.Y., Tsai, LH. (eds) Cyclin Dependent Kinase 5 (Cdk5). Springer, Boston, MA. https://doi.org/10.1007/978-0-387-78887-6_8

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