Regulation and Function of Cdk5 in the Nucleus

  • Qian Yang
  • Zixu Mao


Early studies have shown that Cyclin-dependent kinase 5 (Cdk5) and its regulators function in the neuronal cytoplasm to regulate a range of cellular processes. This seems to distinct Cdk5 from other more traditional Cdks. However, recent discoveries have now extended the role of Cdk5 to the nucleus. This chapter summarizes these novel findings. These include the detection of Cdk5 and its regulators in the nucleus, identification of nuclear targets of Cdk5, and regulation of nuclear Cdk5 and its activators.


Glucocorticoid Receptor Neuronal Death Nuclear Transcription Factor Postmitotic Neuron Cdk5 Kinase Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



The authors apologize for not being able to cite all the relevant studies due to space limitation. This work is supported by NIH AG023695, NS048254, and ES0153170, and by the Robert W. Woodruff Health Sciences Center Fund (Z.M).


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© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  1. 1.Departments of Pharmacology and Neurology, Center for Neurodegenerative DiseaseEmory University School of MedicineAtlantaUSA

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