Overview
- Editors:
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Abel Lajtha
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Center for Neurochemistry, Wards Island, USA
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Table of contents (20 chapters)
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Front Matter
Pages i-xxvii
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- Peter S. Spencer, Matthew S. Miller, Stephen M. Ross, Bradley W. Schwab, Mohammad I. Sabri
Pages 31-65
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- W. Graham McLean, Martin Frizell, Johan Sjöstrand
Pages 67-86
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- Michael J. Zigmond, Edward M. Stricker
Pages 87-102
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- Paul J. Goodnick, Samuel Gershon
Pages 103-149
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- Albert Y. Sun, Grace Y. Sun, Laurie L. Foudin
Pages 173-202
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- Sujata Tewari, Igor A. Sytinsky
Pages 219-261
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- J. E. Leysen, C. J. E. Niemegeers
Pages 331-361
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- Robert J. DeLorenzo, Larry H. Dashefsky
Pages 363-403
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About this book
In neurosciences one may say, '"All roads lead to Rome. " It seems as though wherever one starts, the course of investigation leads to the same major ques tions about nervous system function and dysfunction. In thinking about what to write in this preface, it occurred to me that it might be best to deal with that with which I am most familiar and to trace to some extent my own '"road to Rome. '' As I look over my work of the last 37 years, it becomes clear to me that it can be epitomized as a search for patterns. What usually began as a single minded devotion to in-depth analysis of one or a small number of variables always has led to questions of how the results might relate to the whole living unit, whether it is cell, tissue, or organism. For a number of years after my discovery in the vertebrate central nervous system of -y-aminobutyric acid (GABA) and the enzyme which forms it, L glutamate decarboxylase (GAD), and the identification of GABA as a major inhibitory neurotransmitter by others, I felt that my laboratory, largely bio chemical, was wandering in the wilderness of the complexities of the vertebrate CNS without definitively coming to terms with problems related to GABAergic transmitter functions and the roles of GABA neurons in information processing.
Editors and Affiliations
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Center for Neurochemistry, Wards Island, USA
Abel Lajtha
