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Alcohol

  • Chapter
Alterations of Metabolites in the Nervous System

Abstract

The primary focus of the present chapter is on the neurochemical effects of alcohol (ethanol*) on the central nervous system (CNS). Perspectives are provided on the neurochemical basis of ethanol’s action on the brain. In addition, the roles of energy metabolism, alcohol metabolism, and macromolecular metabolism on the acute and chronic effects of ethanol are discussed. The chapter also discusses how alcohol exposure can modify the fetal and neonatal brain.

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References

  1. Mello, N. K., 1968, Psychopharmacology. A Review of Progress (D. H. Efron, ed.), PHS Publ. No. 1836, U.S. Government Printing Office, Washington, pp. 787–809.

    Google Scholar 

  2. Keller, M., and Rosenberg, S. S. (eds.), 1971, 1974, Alcohol and Health,First special report to the U.S. Congress, DHEW Publication No. (ADM) 74–68, Washington.

    Google Scholar 

  3. Ewing, J. A., and Rouse, B. A. (eds.), 1978, Drinking Alcohol In American Society, Nelson Kay, Chicago.

    Google Scholar 

  4. Victor, M., and Adams, R. D., 1953, Res. Publ. Assoc. Nerv. Ment. Dis. 32: 526–573.

    CAS  Google Scholar 

  5. Knowles, J. B., Laverty, S. G., and Kuechler, H. A., 1968, O. J. Stud. Alcohol 29: 342–349.

    CAS  Google Scholar 

  6. Gross, M. M., and Goodenough, D. R., 1968, Psychiatr. Rev. Rep. 24: 132–147.

    CAS  Google Scholar 

  7. Mayfield, D. G., 1968, J. Nerv. Ment. Dis. 146:314–321, 322–327.

    Google Scholar 

  8. Mello, N. K., and Mendelson, J. H., 1970, J. Pharmacol. Exp. Ther. 173: 101–116.

    PubMed  CAS  Google Scholar 

  9. Mendelson, J. H., 1968, Science 159: 319–320.

    Article  PubMed  CAS  Google Scholar 

  10. Mello, N. K., and Mendelson, J. H., 1969, Neurobiological Aspects of Psychopathology (J. Zubin and C. Shagass, eds.), Grune and Stratton. New York, pp. 183–218.

    Google Scholar 

  11. Jaffee, J. H., and Sharpless, S. K., 1968. The Addictive States (A. Wikler, ed. ), Williams and Wilkins, pp. 226–243.

    Google Scholar 

  12. Turnbull, M. J., and Watkins, J. W., 1976, Eur. J. Pharmacol. 36: 15–20.

    Article  PubMed  CAS  Google Scholar 

  13. Tabakoff, B., Yanai, J., and Ritzmann, R. F., 1979, Science 200: 449–451.

    Article  Google Scholar 

  14. Tewari, S., and Noble, E. 1979, Pharmacology of Ethanol, Volume I (E. Majchorwicz and E. P. Noble, eds.), Plenum Press, New York, pp. 541–548.

    Google Scholar 

  15. Hitzemann, R. J., and Loh, H. H., 1976, Eur. J. Pharmacol. 40: 163–173.

    Article  PubMed  CAS  Google Scholar 

  16. Goth, A.. 1976, Medical Pharmacology, C. V. Mosby Company, St. Louis.

    Google Scholar 

  17. Hudson, P., 1978, Drinking: Alcohol In American Society-Issues and Current Research (J. A. Ewing and B. A. Rouse, eds.), Nelson-Hall, Chicago, pp. 71–92.

    Google Scholar 

  18. Fukui, Y., and Yamamoto, Y., 1972, O. J. Stud. Alcohol A33: 741–750.

    CAS  Google Scholar 

  19. Sytinsky, I. A., 1980, [Biochemical Bases of the Ethanol Action on the Central Nervous System], Meditsina, Moscow.

    Google Scholar 

  20. Chin, J. H., 1979, Biochemistry and Pharmacology of Ethanol, Volume 2 (E. Majchrowicz and E. P. Noble, eds.), Plenum Press, New York, pp. 101–118.

    Chapter  Google Scholar 

  21. a.Stern, L. S., 1935, [Hemato-encephalic bander, Collected Works of L. S. Stern and Coworkers], Moscow, Leningrad.

    Google Scholar 

  22. b.Kassil’, G. N.. 1963, [Hemato–Encephalic Barrier], Academy of Sciences of the USSR, Moscow.

    Google Scholar 

  23. Hillbom, M. E., and Tervo, T. M. T., 1981, Experientia 37: 936–938.

    Article  PubMed  CAS  Google Scholar 

  24. Butenko, G. M., 1962, [Permeability of Hemato-encephalic and Hemato-Ophtalmic Barriers under Alcohol Intoxication],dissertation, Odessa.

    Google Scholar 

  25. Rössner, W., and Nusstein, R., 1972, Zbl. Veterinarmed. A19: 519–522.

    Article  Google Scholar 

  26. Shiyan, I. V., 1961, [State of Tonus and Pentrability of Vessels under Chronic Alcoholism],dissertation, Vitebsk.

    Google Scholar 

  27. Bespalow, L. P., 1972, [Vascular and Exsogeno-Toxic Illnesses of Nervous System],dissertation, Smolensk, pp. 72–74.

    Google Scholar 

  28. Fritchie, G. E., Ho, B. T., and Mclsaac, N. M., 1971, Biological Aspects of Alcohol (M. E. Roach, N. M. Mclsaac, and F. J. Creaven, eds.), University of Texas Press, Austin, pp. 185–292.

    Google Scholar 

  29. Nazarov, G. M., 1966, Collected Works, Volume N49, Leningrad Institute for Advanced Training of Physicians, Leningrad, p. 155.

    Google Scholar 

  30. Erickson, C. K., 1976, Life Sci. 19: 1439–1446.

    Article  PubMed  CAS  Google Scholar 

  31. Bauer-Moffett, C., and Altman, Jr., 1977, Brain Res. 119: 249–268.

    Article  PubMed  CAS  Google Scholar 

  32. Galeeva, L. 1976, [Problems of Psychiatry],Alma-Ata, pp. 48–50.

    Google Scholar 

  33. Veloso, D., Passonneau. J. V., and Veech, R. L., 1980, J. Neurochem. 19: 2679–2685.

    Article  Google Scholar 

  34. Tewari, S., and Carson, V., 1982, The American Handbook of Alcoholism (E. M. Pattison and E. Kaufman, eds.), Gardner Press, New York, pp. 83–104.

    Google Scholar 

  35. Tabakoff, B., and Gelpke, C. C., 1975, Adv. Exp. Med. Biol. 56: 141–162.

    Article  PubMed  CAS  Google Scholar 

  36. Sloviter, H. A., 1979, Biochemistry and Pharmacology of Ethanol, Volume 1 (E. Majchrowicz and E. P. Noble, eds.), Plenum Press, New York, pp. 505–520.

    Chapter  Google Scholar 

  37. Raskin, N. H., and Sokoloff, L., 1968, Science 162: 131–132.

    Article  PubMed  CAS  Google Scholar 

  38. Raskin, N. H., and Sokoloff, L., 1974, J. Neurochem. 22:427–439.

    Article  PubMed  CAS  Google Scholar 

  39. Raskin, N. H., and Sokoloff, L.. 1972, Nature [New Biol.] 236: 138–140.

    CAS  Google Scholar 

  40. Hassinen, I. E., Hakkinen, M. N. A., and Ylikahri, R. H., 1974, Brain Res. 70: 301–312.

    Article  PubMed  CAS  Google Scholar 

  41. Weiner, H., 1979. Biochemistry and Plasmacology of Ethanol, Volume 1 (E. Machewicz and E. P. Noble, eds.), Plenum Press, New York. pp. 107–124.

    Chapter  Google Scholar 

  42. Majchrowicz, E.. 1975, Adc. Exp. Med. Biol. 56: 111–140.

    Article  CAS  Google Scholar 

  43. Roach, M. K., and Reese, W. N.. 1971, Biochem. Pharmacol. 20: 2805–2812.

    Article  PubMed  CAS  Google Scholar 

  44. Rawat, A. K., 1975, Adc. Exp. Med. Biol. 56: 165–177.

    Article  CAS  Google Scholar 

  45. Deitrich, R. A.. 1976. Psychoneuroendocrinologv 1: 325–346.

    Article  CAS  Google Scholar 

  46. Sytinsky, I. A., Konovalova. N. V., and Nikitina. Z. S.. 1977, Pharmacol. Toxicol. 40: 361–366.

    Google Scholar 

  47. Reed, W. D., and Mezey. E., 1972, Life Sci. 11: 847–857.

    Article  CAS  Google Scholar 

  48. Nikulin. A. A., 1977. Pharmacol. Toxicol. 40: 359–361.

    Google Scholar 

  49. Pauling. L., 1961, Science 134: 15–21.

    Article  PubMed  Google Scholar 

  50. Noble, E. P.. and Tewari. S.. 1977, Metabolic-Aspects of Alcoholism (Charles S. Lieber. ed.), MTP Press. London. pp. 149–185.

    Chapter  Google Scholar 

  51. Rawat. A. K., Kuriyama. K.. and Moze. J., 1973, J. Neta-ochem. 20: 23–33.

    CAS  Google Scholar 

  52. Veech. R. L., Harris, R. L..-and Mehlman, M. A.. 1974, Toxicol. Appl. Pharmacol. 29: 196–203.

    Article  PubMed  CAS  Google Scholar 

  53. Amirhanyan, L. T., and Karagezyan, K. G., 1974, Prob. Brain Biochem. Erevan 9: 42–63.

    Google Scholar 

  54. Karagezyan, K. G., Amirhanyan, O. M.. Amirhanyan. L. T.. and Alexandryan, D. V.. 1966. Prob. Med. Chem. 22: 30–33.

    Google Scholar 

  55. Rawat, A. K.. 1974, Res. Commun. Chem. Pathol. Pharmacol. 8: 461–469.

    PubMed  CAS  Google Scholar 

  56. Littleton, J. M.. and John, G.. 1977, J. Pharm. Pharmacol. 29: 579–580.

    Article  PubMed  CAS  Google Scholar 

  57. Sun. G. Y., Creech, D. M.. Corbin. D. R., and Sun, A. Y.. 1977, Res. Commun. Chem. Pathol. Pharmacol. 16: 753–756.

    Google Scholar 

  58. Wallgren, H.. Nikander. P.. and Virtanen. P.. 1975, Adc. E.rp. Med. Biol. 59: 23–36.

    CAS  Google Scholar 

  59. Virtanen, P.. 1977. Adv. E.rp. Sled. Biol. 85A: 193–202.

    Google Scholar 

  60. Lesch, P., and Remberg. G.. 1973, Klin. Wochenschr. 51: 132–134.

    Article  PubMed  CAS  Google Scholar 

  61. Lesch, P., Schmidt. E., and Schmidt. F. W., 1973, Z. Klin. Chem. Klin. Biochem. 2: 159–166.

    Google Scholar 

  62. Erickson, C. K.. and Graham, D. T.. 1973, J. Pharmacol. E.rp. Ther. 185: 583–593.

    CAS  Google Scholar 

  63. Graham. D. T., and Erickson. C. K.. 1974. Psvchopharmacologia (Berl.) 34: 173–180.

    Article  Google Scholar 

  64. Rawat, A. K.. 1974. J. Neurochern. 22: 915–922.

    Article  CAS  Google Scholar 

  65. Behtel’, E. E., 1972, [Problems of Clinics. Pathogenesis and Therapy of Psychic Illnesses]. Moscow. p. 228.

    Google Scholar 

  66. Blagova, O. E., Konovalova, N. N.. Nikitina. Z. S., and Sytinsky. I. A.. 1978. Problems of Biochemistry of Nervous System, Volume N19, Leningrad University. Leningrad. pp. 128–135.

    Google Scholar 

  67. Sytinsky. I. A.. 1971. J. rVeuropathol. Psychiatry 71: 197–304.

    Google Scholar 

  68. Sytinsky, I. A., 1975, Prog. Physiol. Sci. 6: 49–84.

    Google Scholar 

  69. Sytinsky, I. A.. 1976, D. I. Mendeleev J. All-Union Chem. Soc. 21: 137–144.

    Google Scholar 

  70. Sytinsky, I. A.. 1977, Garnma-Aminobutyric Acid-an Inhibitory Transmitter, Nauka, Leningrad.

    Google Scholar 

  71. Rix, K. S. B.. 1977. Alcohol and Alcoholism, Eden Press. Montreal.

    Google Scholar 

  72. Chan. A. W. K.. 1979. Res. Commun. Psycho!. Psychiatry Behac. 4: 277–284.

    Google Scholar 

  73. Gordon, E. R., 1967. Can. J. Physiol. Pharmacol 45: 915–918.

    Article  PubMed  CAS  Google Scholar 

  74. Hakkinen, H. M., and Kulonen. E., 1972. Biochem. Pharmacol. 21: 1171–1186.

    Article  PubMed  CAS  Google Scholar 

  75. Higgins, E. S., 1962, Biochem. Pharmacol. 11: 394–395.

    Article  PubMed  CAS  Google Scholar 

  76. Okamoto, Y., Murayam, T.. and Ogata. M., 1979, Fol. Psychiatr. Neurol. Jpn. 33: 111–121.

    CAS  Google Scholar 

  77. Sutton, L, and Simonds, M.. 1973, Biochem. Pharmacol. 22: 1685–1692.

    Article  PubMed  CAS  Google Scholar 

  78. Sytinsky. I. A., and Priyatkina, T. N.. 1964. Fed. Proc.]Trans. Suppl.] 23: 879–880.

    Google Scholar 

  79. Chopde, C. T., Brahmankar. D. M.. and Shripad, V. N.. 1977. J. Pharmacol. Exp. Ther. 200: 314–319.

    PubMed  CAS  Google Scholar 

  80. Leitch, G. J.. Rackas. D. J., Siegman, F. S., and Guthrie. G. D.. 1977. Experientia 33: 496–497.

    Article  PubMed  CAS  Google Scholar 

  81. Patel, J. G., and Lal, H., 1973, J. Pharmacol. Exp. Ther. 186: 625–629.

    PubMed  CAS  Google Scholar 

  82. Tabakoff. B., and Boggan, W. O., 1974. J. Neurochern. 22: 759–764.

    Article  Google Scholar 

  83. Goldstein, D. B., 1973, J. Pharmacol. Exp. Ther. 186: 1–9.

    PubMed  CAS  Google Scholar 

  84. Goldstein, D. B.. 1979, J. Pharmacol. Exp. Ther. 208: 223–227.

    PubMed  CAS  Google Scholar 

  85. Noble, E. P., Gillies. H.. Vigran, R.. and Mandel. P., 1976, Psychopharmacologia (Berl.) 46: 127–131.

    Article  CAS  Google Scholar 

  86. Cooper, B. R., Viik, K., Ferris, R. M., and White, H. H., 1979, J. Pharmacol. Exp. Ther. 209: 396–403.

    PubMed  CAS  Google Scholar 

  87. Davis, V. E., Brown, H., Huft, J. A., and Cashow, J. L., 1967, J. Lab. Clin. Med. 69: 132–140.

    PubMed  CAS  Google Scholar 

  88. Tytell, M., and Myers, R. D., 1973, Biochem. Pharmacol. 22: 361–372.

    Article  PubMed  CAS  Google Scholar 

  89. Feldstein, A., and Sidel, C. M., 1969, Int. J. Neuropharmacol. 8: 347–351.

    Article  PubMed  CAS  Google Scholar 

  90. Palaic, D. J., Desaty, J., Albert, J. M., and Panisset, J. C., 1971, Brain Res. 25: 381–386.

    Article  PubMed  CAS  Google Scholar 

  91. Gursey, D., and Olson, H. E., 1969, Proc. Soc. Exp. Biol. Med. 104: 280–281.

    Google Scholar 

  92. Hunt, W. A., and Majchrowicz, E., 1974, Brain Res. 72: 181–184.

    Article  PubMed  CAS  Google Scholar 

  93. Kuriyama, K., Rauscher, G. E., and Sze, P. Y., 1971, Brain Res. 26: 450–454.

    PubMed  CAS  Google Scholar 

  94. Pohorecky, L. A., Jaffe, L. S., and Berkeley, H. A., 1974, Res. Commun. Chem. Pathol. Pharmacol. 8: 1–11.

    PubMed  CAS  Google Scholar 

  95. Detering, N., Collins, R. M., Hawkins, R. L., Ozane, P. T., and Karahasaw, A., 1980, J. Neurochem. 34: 1788–1791.

    Article  PubMed  CAS  Google Scholar 

  96. Anokhina, I. P., 1975, Abstracts of Reports at YI. All-Union Congress of Neuropathology and Psychiatry, Moscow, Volume 1, pp. 287–294.

    Google Scholar 

  97. Anokhina, I. P., and Kogan, B. M., 1975, J. Neuropathol. Psychiatry 75: 1874–1883.

    CAS  Google Scholar 

  98. Erickson, C. K., Lau, A. S., Schultz, J. D., and Matchette, J. A., 1975, Satellite Symposium 6th International Congress of Pharmacology, The Finnish Foundation for Alcohol Studies, Helsinki, Volume 23 (K. O. Lindros and C. J. P. Erickson, eds. ), pp. 176–186.

    Google Scholar 

  99. Naimova, T. G., 1978, Pharmacol. Toxicol. 41: 49–52.

    CAS  Google Scholar 

  100. Nikki, P., Vapaatalo, H., and Karppanen, H., 1971, Ann. Med. Exp. Biol. Fenn. 49: 157–161.

    PubMed  CAS  Google Scholar 

  101. Yamanaka, Y., and Kono, S., 1974, Hiroshima J. Med. Sci. 23: 105–113.

    PubMed  CAS  Google Scholar 

  102. Wajda, I. J., Manigault, I., and Hudick, J. P., 1977, Biochem. Pharmacol. 26: 653–655.

    Article  PubMed  CAS  Google Scholar 

  103. Ahtee, L., and Ericksson, K., 1975, Acta Physiol. Scand. 93: 563–565.

    Article  PubMed  CAS  Google Scholar 

  104. Mazur, M., and Szmigielski, A., 1976, Acta Physiol. Polska 27: 281–286.

    CAS  Google Scholar 

  105. Friedhoff, A. J., and Miller, J., 1973, Ann. N.Y. Acad. Sci. 215: 183–186.

    Article  PubMed  CAS  Google Scholar 

  106. Gysling, K., Bustos, G., Concha, I., and Martinez, G., 1976, Biochem. Pharmacol. 25: 157–162.

    Article  PubMed  CAS  Google Scholar 

  107. Bustos, G., Roth, R. H., and Morgenroth, V. H., 1976, Biochem. Pharmacol. 25: 2493–2497.

    Article  PubMed  CAS  Google Scholar 

  108. Pohorecky, L. A., Jaffe, L. S., and Berkeley, H. A., 1974, Life Sci. 15: 427–437.

    Article  PubMed  CAS  Google Scholar 

  109. Knroum, F., Wyatt, R. J., and Majchrowicz, 1976, Br. J. Pharmacol. 56: 405–411.

    Google Scholar 

  110. Littleton, J. M., Griffiths, P. J., and Ortiz, A., 1974, J. Pharm. Pharmacol. 26: 81–91.

    Article  PubMed  CAS  Google Scholar 

  111. Blum, K., and Wallace, J. E., 1974, Br. J. Pharmacol. 51: 109–111.

    Article  PubMed  CAS  Google Scholar 

  112. Ahtee, L., and Svarstrom-Fraser, M., 1975, Acta Pharmacol. Toxicol. (Kbh).

    Google Scholar 

  113. Goldstein, D. B., 1975, Fed. Proc. 34: 1953–1961.

    PubMed  CAS  Google Scholar 

  114. Collier, H. O. J., Hammond, M. P., and Schneider, C., 1974, Br. J. Pharmacol. 51: 310–311.

    Article  PubMed  CAS  Google Scholar 

  115. Darden, J. H., and Hunt, W. A., 1977, J. Neurochem. 29: 1143–1145.

    Article  PubMed  CAS  Google Scholar 

  116. Blum, K., Eubanks, J. D., Wallace, J. E., and Schwertner, H. A., 1976, Experientia 32: 493–495.

    Article  PubMed  CAS  Google Scholar 

  117. Davis, V. E., and Walsh, M. S., 1971, Biologocal Basis of Alcoholism (Y. Israel and J. Mardones, eds.), Wiley-Interscience, New York, Toronto, pp. 73–102.

    Google Scholar 

  118. Rahwan, R. G., 1974, Life Sci. 15: 617–633.

    Article  PubMed  CAS  Google Scholar 

  119. Cohen, G., 1976, Biochem. Pharmacol. 25: 1123–1128.

    Article  PubMed  CAS  Google Scholar 

  120. a.Davis, V. E., Walsh, M. J., and Yamanaka, Y., 1970, J. Pharmacol. Exp. Ther. 174: 401–412.

    Google Scholar 

  121. Shaeb, S. E., and Dajani, R. M., 1973, Comp. Gen. Pharmacol. 4: 225–227.

    Article  Google Scholar 

  122. Sandler, M., Carter, S. B., Hunter, K. R., and Stern, G. M., 1973. Nature 241: 439–443.

    Article  PubMed  CAS  Google Scholar 

  123. Collings, M. A., 1977, Alcohol and Opiates. Neurochemical and Behavioral Mechanisms, Academic Press, New York, pp. 155–166.

    Google Scholar 

  124. Melchior, C. L., and Myers, R. D., 1977, Pharmacol. Biochem. Behay. 7: 19–35.

    Article  CAS  Google Scholar 

  125. Myers, R. D., and Melchior, C. L., 1977, Science 196: 554–555.

    Article  PubMed  CAS  Google Scholar 

  126. Myers, R. D., and Oblinger, M. M., 1977, Drug Alcohol Depend. 2: 464–483.

    Article  Google Scholar 

  127. Duncan, C., and Deitrich, R. A., 1980, Pharmacol. Biochem. Behay. 13: 265–281.

    Article  CAS  Google Scholar 

  128. Haluska, P. V., and Hoffman, P. C., 1970, Science 169: 1104–1105.

    Article  Google Scholar 

  129. Collins, M. A., and Bigdeli, M. G., 1975, Life Sci. 16: 585–602.

    PubMed  CAS  Google Scholar 

  130. Alivisatos, S. G. A., and Arora, R. C., 1975, Adv. Exp. Med. Biol. 56: 255–263.

    Article  PubMed  CAS  Google Scholar 

  131. Kuriyama, K., Sze, P. Y., and Rauscher, G. E., 1971, Life Sci. 10: 181–189.

    Article  CAS  Google Scholar 

  132. Choy, O. H., Ford, D. H., and Rhines, R. K., 1972, Acta Neurol. Scand. 48: 341.

    Article  PubMed  CAS  Google Scholar 

  133. Jarlstedt, J., and Hamberger, A., 1972, J. Neurochem. 19: 2299–2306.

    Article  PubMed  CAS  Google Scholar 

  134. Renis, M., Giovine, A., and Bertolino, A., 1975, Life Sci. 16: 1447.

    Article  PubMed  CAS  Google Scholar 

  135. Häkkinen, H. M., and Kulonen, E., 1969, J. Neurochem. 33: 943–946.

    Article  Google Scholar 

  136. Jarlstedt, J., 1972, J. Neurochem. 19: 603–608.

    Article  PubMed  CAS  Google Scholar 

  137. Noble, E. P., and Tewari, S., 1973, Ann. N.Y. Acad. Sci. 215: 333–345.

    Article  PubMed  CAS  Google Scholar 

  138. Syapin, P. J., Tewari, S., and Noble, E. P., 1974, Proc. West. Pharmacol. Soc. 17: 184–187.

    CAS  Google Scholar 

  139. Morland, J., and Sjetnan, A. E., 1976, Biochem. Pharmacol. 25: 220–221.

    Article  PubMed  CAS  Google Scholar 

  140. Sedman, G. L., Austin, I., and Langford, C. J., 1982, Neurosci. Lett. 28: 93–99.

    Article  PubMed  CAS  Google Scholar 

  141. Wasterlain, C. G., Dwyer, B. E., Fando, J., Fando, M. C., and Lieber, C. S., 1983, Research Monograph-10, Alcohol and Protein Synthesis, U.S. Department of Health and Human Services, Public Health Service, Alcohol, Drug Abuse and Mental Health Administration, Washington, pp. 199–218.

    Google Scholar 

  142. Tewari, S., Goldstein, M. A., and Noble, E. P., 1977, Brain Res. 126: 509–518.

    Article  PubMed  CAS  Google Scholar 

  143. Kuriyama, K., Rauscher, G. E., and Sze, P. Y., 1971, Brain Res. 26: 450–454.

    PubMed  CAS  Google Scholar 

  144. Friedhoff, A. J., and Miller, J., 1973, Ann. N.Y. Acad. Sci. 215: 183–194.

    Article  PubMed  CAS  Google Scholar 

  145. Tewari, S., and Noble, E. P., 1977, Alcohol and Aldehyde Metabolizing Systems, 2 (R. G. Thurman, J. R. Williamson, H. R. Drott, and B. Chance, eds.), Academic Press, New York, pp. 613–624.

    Google Scholar 

  146. Noble, E. P., and Tewari, S., 1975, Fed. Proc. 34: 1942–1947.

    PubMed  CAS  Google Scholar 

  147. Tewari, S., and Noble, E., 1975, Alcohol and Abnormal Protein Biosynthesis (M. A. Rothchild, M. Oratz, and S. S. Schreiber, eds.), Pergamon Press, New York, pp. 421–448.

    Google Scholar 

  148. Tewari, S., Dobyns, J., and Noble, E., 1978, 32nd International Congress on Alcoholism and Drug Dependence, Warsaw, Poland (in press).

    Google Scholar 

  149. Tewari, S., Duerbeck, N. B., and Noble, E. P., 1978, Res. Commun. Chem. Pathol. Pharmacol. 22: 401–418.

    PubMed  CAS  Google Scholar 

  150. Tewari, S., Duerbeck, N. B., Ross-Duggan, J., and Noble, E. P., 1978, Res. Commun. Chem. Pathol. Pharmacol. 22:(2)385–400.

    PubMed  CAS  Google Scholar 

  151. Tewari, S., Sweeney, F., and Fleming, E., 1980, Neurochem. Res. 5:(9)1019–1029.

    Article  Google Scholar 

  152. Toth, E., and Lajtha, A., 1983, Research Monograph 10, Alcohol and Protein Synthesis. U.S. Dept. of Health and Human Services, Public Health Service, Alcohol, Drug Abuse, and Mental Health Administration, Washington, pp. 3–16.

    Google Scholar 

  153. Tewari, S., Murray, S. L., and Noble, E. P., 1978, J. Neurosci. Res. 3: 375–387.

    Article  PubMed  CAS  Google Scholar 

  154. Lajtha, A., Dunlop, D., Patlak, C., and Toth, J., 1979, Biochim. Biophys. Acta 581: 390–401.

    Google Scholar 

  155. Ritzmann, L. A., and Tabakoff, B., 1976, J. Pharmacol. Exp. Ther. 199: 158–170.

    PubMed  CAS  Google Scholar 

  156. Fleming, E. W., Woodson, M. E., and Tewari, S., 1981, J. Neurosci. Res. 6: 511–524.

    Article  PubMed  CAS  Google Scholar 

  157. Woodson, M., Daly, C., Fleming, E., and Tewari, S., 1981, Ethanol alters protein synthesis in astrocytoma cells in exponential plane, Am. Soc. Neurochem. 12: 225.

    Google Scholar 

  158. Devi, G. G., Anderson, K. P., and Wagner, E. K., 1983, Research Monograph 10, Alcohol and Protein Synthesis, U.S. Dept. of Health and Human Services, Washington, pp. 171–197.

    Google Scholar 

  159. Tewari, S., Fleming, E. W., and Noble, E. P., 1975, J. Neurochem. 24: 561–569.

    Article  PubMed  CAS  Google Scholar 

  160. Tewari, S., and Noble, E. P., 1975, Adv. Exp. Med. Biol. 59: 37–53.

    PubMed  CAS  Google Scholar 

  161. Fleming, E. W., Tewari, S., and Noble, E. P., 1975, J. Neurochem. 24: 553–560.

    Article  PubMed  CAS  Google Scholar 

  162. Boylan, K., and Tewari, S., 1983, Research Monograph 10: Alcohol and Protein Synthesis, U.S. Department of Health and Human Services, pp. 343–344.

    Google Scholar 

  163. Lamar, C., 1972, Brain Res. 44: 698–700.

    Article  PubMed  CAS  Google Scholar 

  164. Syapin, P. J., Tewari, S., and Noble, E. P., 1978, Adv. Exp. Med. Biol. 126: 283–298.

    Google Scholar 

  165. Gruber, B., Dinovo, E. C., Noble, E. P., and Tewari, S., 1977, Biochem. Pharmacol. 26: 2181–2185.

    Article  PubMed  CAS  Google Scholar 

  166. Fleming, E., and Tewari, S., 1981, Alcohol. Clin. Exp. Res. 5 (3): 400–409.

    Article  PubMed  CAS  Google Scholar 

  167. Tewari, S., Stewart, R., and Fleming, E. W., 1981, Res. Commun. Substance Abuse 2: 93–96.

    CAS  Google Scholar 

  168. Tewari, S., Greenberg, S., and Smith, H., 1981, Alcohol. Clin. Exp. Res. 5: 170.

    Google Scholar 

  169. Tewari, S., Greenberg, S., and Gray, P., 1984, Substance and alcohol actions/misuse (in press).

    Google Scholar 

  170. Rosnowska, M., and Tewari, S., 1983, Research Monograph 10, Alcohol and Protein Synthesis, DHHS Publication No. ADM) 83–1198, U.S. Dept. of Health and Human Services, PHS, National Institution of Alcohol Abuse and Alcoholism, Washington, pp. 309–322.

    Google Scholar 

  171. Clegg, D. J., 1971, Anna. Rev. Pharmacol. 11: 409–424.

    Article  CAS  Google Scholar 

  172. Clarren, S. K., and Smith, D. W., 1978, N. Engl. J. Med. 298: 1063–1067.

    Article  PubMed  CAS  Google Scholar 

  173. Schrauzer, G. N., McGinnes, J. E., Ishmael, D., and Bell, L. J., 1979, J. Stud. Alcohol 40: 240–246.

    PubMed  CAS  Google Scholar 

  174. Zervoudakis, I. A., Krauss, A., and Fuchs, F., 1980, Am. J. Obstet. Gynecol. 137: 713–718.

    PubMed  CAS  Google Scholar 

  175. Heinonen, O. P., Sloan, D., Monson, R. R., Hook, E. B., and Shapiro, S., 1977, N. Engl. J. Med. 296: 67–70.

    Article  PubMed  CAS  Google Scholar 

  176. Redmond, G. P., 1980, Alcoholism 198 (1): 50–56.

    Google Scholar 

  177. Streissguth, A., 1976, Ann. N.Y. Acad. Sci. 273: 140–145.

    Article  PubMed  CAS  Google Scholar 

  178. Rosett, H., Weiner, L. W., 1982. Encylopedic Handbook of Alcoholism (E. M. Pattison and E. Kaufman), Gardner Press, New York, pp. 301–310.

    Google Scholar 

  179. Ellis, F. W., and Pick, J., 1976. Pharmacology 19: 190.

    Google Scholar 

  180. Sze, P., Yanai, J., and Ginsburg, P., 1976, Biochem. Pharmacol. 25: 215–217.

    Article  PubMed  CAS  Google Scholar 

  181. Abel, E. L., 1974, Arch. Int. Pharmacol. 310: 121–127.

    Google Scholar 

  182. Yanai, J., and Ginsburg, B., 1976, J. Stud. Alcohol 37: 1564–1571.

    PubMed  CAS  Google Scholar 

  183. Wilson, K., Landesman, R., Ruchs, A., and Fuchs, F., 1969, Am. J. Obstet. Gynecol. 104: 436–439.

    CAS  Google Scholar 

  184. Seppala, M., Raiha, W., and Tamminen, V., 1971, Lancet 1: 1188–1189.

    Article  PubMed  CAS  Google Scholar 

  185. Waltman, R., and Inequez, E., 1972, Obstet. Gynecol. 40: 180–185.

    PubMed  CAS  Google Scholar 

  186. Pikkaräinen, P. H., and Raiha, N. C. R., 1967, Pediatr. Res. 1: 165–168.

    Article  PubMed  Google Scholar 

  187. Kesaniemi, Y. A., 1974, Biochem. Pharmacol. 23: 1157–1162.

    Article  PubMed  CAS  Google Scholar 

  188. Kesaniemi, Y. A., and Sippel, H. W., 1975, Acta Pharmacol. Toxicol. (Kbh.) 37: 43–48.

    Article  CAS  Google Scholar 

  189. Rawat, A. K., 1976, Biochem. J. 160: 653–661.

    PubMed  CAS  Google Scholar 

  190. Bauer-Moffett, C., and Altman, J., 1975, Exp. Neurol. 48: 378–383.

    Article  PubMed  CAS  Google Scholar 

  191. Mann, L. I., Bhakthavathealan, A., Liu, M., and Makowski, P., 1975, Am. J. Obstet. Gynecol. 122: 845–851.

    CAS  Google Scholar 

  192. Fritchie, G. E., Ho, B. T., and McIsaac, N. M., 1971. Biological Aspects of Alcohol (M. E. Roach, N. M. Mclsaac, and F. J. Creaven, eds.), University of Texas Press, Austin, pp. 285–292.

    Google Scholar 

  193. Gärtner, U., and Ryden, G., 1972, Acta Paediatr. Scand. 61: 720–721.

    Article  PubMed  Google Scholar 

  194. Ho, B., Fritchie, G., Heikkilau, T., and Mclsaac, N. M., 1972, Q. J. Stud. Alcohol 33: 485–493.

    PubMed  CAS  Google Scholar 

  195. Akessenn, C., 1974, Arch. Int. Pharmocodyn. Ther. 209: 296–304.

    Google Scholar 

  196. Tewari, S., and Christine, M., 1983, Biological Approach to Alcoholism, Research Monograph No. 11,U.S. Department of Health and Human Services. ADAMHA. National Institute on Alcohol Abuse and Alcoholism, Washington, pp. 63–78.

    Google Scholar 

  197. Fisher, S. E.. Atkinson, M., Van Thiel. D. H., Rosenblum, E.. David, B., and Holzman, I., 1981, Life Sci. 29: 1283–1288.

    Article  PubMed  CAS  Google Scholar 

  198. Hagerman, D. D., 1969, Foetus and Placenta (A. Klopper and E. Diezfalusy, eds.), Blackwell Scientific Publications, Oxford, pp. 413–469.

    Google Scholar 

  199. a.Hagerman, D. D., 1964, Fed. Proc. 23: 785–790.

    Google Scholar 

  200. Krassner, J., Tischler, F., and Yaffe, S. J., 1976, J. Med. 7: 323–337.

    Google Scholar 

  201. Sjoblum, M.. Pilstrom, L., and Morland, J., 1978. Enzyme 23: 108–115.

    Google Scholar 

  202. Kouri, M., Koivula, T., and Koivulsalo, M., 1977, Acta Pharmacol. Toxicol. (Kbh.) 40: 460–464.

    CAS  Google Scholar 

  203. Brown, N. A., Goulding, E. H., and Fabro, S., 1979, Science 206: 573–575.

    Article  PubMed  CAS  Google Scholar 

  204. Daniels, M., and Evans, M. A., 1980, Fed. Proc. 39: 846.

    Google Scholar 

  205. O’Shea, K. S., and Kaufman, M. H., 1979, J. Anat. 128: 65–76.

    PubMed  Google Scholar 

  206. Henderson, G. I., Patwardhan, R., and Hoyumpa, A. M., 1983, Research Monograph No. 10. Alcohol and Protein Synthesis, U.S. Dept. of Health and Human Services, Public Health Service, Alcohol, Drug Abuse, and Mental Health Administration, Washington, pp. 17–30.

    Google Scholar 

  207. Rawat, A. K., 1975, Res. Commun. Chem. Pathol. Pharmacol. 12: 723–732.

    PubMed  CAS  Google Scholar 

  208. Khawaja, J. W., Wallgren, H., Usmi, H., and Hilska, P., 1978, Res. Commun. Chem. Pathol. Pharmacol. 22 (3): 573–580.

    PubMed  CAS  Google Scholar 

  209. Tewari, S., and Crain, S., 1979, Alcohol and Aldehyde Metabolizing Systems, 4 (R. G. Thurman, ed.), Plenum Press, New York, pp. 813–821.

    Google Scholar 

  210. Rawat, A. K., 1983, Research Monograph 10, Alcohol and Protein Synthesis, U.S. Dept. of Health and Human Services, Washington, pp. 111–150.

    Google Scholar 

  211. Tewari, S., Do, K., and Medina, R., 1983, 14th Annual Meeting, American Society for Neurochemistry Meetings, Honolulu, 14: 117.

    Google Scholar 

  212. Henderson, G. 1., and Schenker, S., 1977, Res. Commun. Chem. Pathol. Pharmacol. 16: 1532.

    Google Scholar 

  213. Fisher, S., Barnicke, M., Streis, B., Holzman, I., and Van Thiel, D.. 1973, Pediatr. Res. 15: 335–339.

    Article  Google Scholar 

  214. Dreosti, I., Ballard, F. J., and Belling, G. B.. Record, I. R., Manuel, S. J., 1981, Alcohol. Clin. Exp. Res. 5: (3): 357–363.

    Article  PubMed  CAS  Google Scholar 

  215. Feldstein, A., 1971, The Biology of Alcoholism, f., Biochemistry (B. Kissin and H. Begleiter, eds.), Plenum Press, New York, pp. 127–159.

    Chapter  Google Scholar 

  216. Branchy, L., and Friedhoff, A. J.. 1973, Psychopharmacology 32: 151–156.

    Article  Google Scholar 

  217. Yanai, J.. and Tabakoff, B., 1980. Psychopcologia 68: 301–303.

    CAS  Google Scholar 

  218. Abel, E. L.. Bush, R., and Dintcheff, B. A., 1981, Science 212: 1531–1533.

    Article  PubMed  CAS  Google Scholar 

  219. Tewari, S., Clarke, J., Milligan, S., and Do. K., 1984, Fifteenth Annual Meeting, Am. Soc. Neurochem. 15: 324.

    Google Scholar 

  220. Sullik, K., Johnston, M., and Webb, M., 1981, Science 214: 936–938.

    Article  Google Scholar 

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Authors and Affiliations

  1. Alcohol Research Center, Department of Psychiatry and Human Behavior, University of California, Irvine, California, 92717, USA

    Sujata Tewari

  2. Leningrad State University, 191025, Leningrad, USSR

    Igor A. Sytinsky

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  1. Sujata Tewari
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  2. Igor A. Sytinsky
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  1. Center for Neurochemistry, Wards Island, New York, USA

    Abel Lajtha

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Tewari, S., Sytinsky, I.A. (1985). Alcohol. In: Lajtha, A. (eds) Alterations of Metabolites in the Nervous System. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-6740-7_9

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