Skip to main content
SpringerLink
Log in
Book cover

Alterations of Metabolites in the Nervous System pp 263–278Cite as

Nicotine

  • Chapter

  • 42 Accesses

Abstract

Nicotine, one of the compounds that alter brain function, has been shown to have diverse actions in the CNS. Although there has been considerable interest in the effects of nicotine and tobacco smoking in man and other species, the mechanisms and sites of action of nicotine in the brain are not clearly understood. It has been shown in many experiments that nicotine can influence behavior. Examples are the facilitatory effect of nicotine on self-stimulation,1 the dose-dependent facilitation of avoidance learning,2 the increased performance of learned tasks, and the decrease of task acquisition.3 Improved memory retention after nicotine administration has been suggested to be related to nicotine’s stimulant properties, altering the arousal state after training,4 and not to direct effects on the rate of protein synthesis. Although nicotine reverses the amnestic effects of cycloheximide treatment,5 reversal of the inhibition of protein synthesis is not involved.6 Nicotine increases the release of several biogenic amines and neuropeptides; release of norepinephrine and hydroxytryptamine is increased in brain homogenates,7 and release from the pituitary of ACTH8 and vasopressin9 is also increased. During fetal development, nicotine may affect brain function and development,10 possibly as a result of decreased protein synthesis.11,12

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Pradhan, S. N., and Bowling, C., 1971, J. Pharmacol. Exp. Ther. 176: 229–243.

    PubMed  CAS  Google Scholar 

  2. Bovet, D., Bovet-Nitti, F., and Oliverio, A.. 1969, Science 163: 139–149.

    PubMed  CAS  Google Scholar 

  3. Nelsen, J. M., 1974, Drug Addiction, Neurobiology and Influences on Behavior. Volume 3 (J. M. Singh and H. Lal, eds.), Grune and Stratton, New York, pp. 375–386.

    Google Scholar 

  4. Flood, J. F., Bennett. E. L., Orme. A. E., Rosenzweig, M. R., and Jarvik. M. E., 1978, Science 199: 324–326.

    PubMed  CAS  Google Scholar 

  5. Stamm. E. R., and Schlesinger, K., 1980, J. Comp. Psychol. 94: 1184–1190.

    Google Scholar 

  6. Sershen, H., Reith, M. E. A., and Lajtha, A., 1982, Brain Res. 251: 183–185.

    PubMed  CAS  Google Scholar 

  7. Balfour, D. J. K., 1973, Eur. J. Pharmacol. 23: 19–26.

    PubMed  CAS  Google Scholar 

  8. Cam, G. R., Bassett, J. R., and Cairncross, K. D., 1979, Arch. Int. Pharmacodyn. Ther. 237: 49–66.

    PubMed  CAS  Google Scholar 

  9. Reaves, T. A., Jr., Liu, H. M., Oasim, M., and Hayward, J. N., 1981, Peptides 2: 13–17.

    PubMed  CAS  Google Scholar 

  10. Hudson, D. B., Meisami, E., and Timiras, P. S., 1973, Experientia 29: 286–288.

    PubMed  CAS  Google Scholar 

  11. Sershen, H., and Lajtha, A., 1979, Neuropharmacology 18: 763–766.

    Google Scholar 

  12. Sershen, H., Reith, M. E. A., Banay-Schwartz, M., and Lajtha, A., 1982, Neurochem. Res. 7: 1515–1522.

    PubMed  CAS  Google Scholar 

  13. Schleifer, L. S., and Eldefrawi, M. E.. 1974, Neuropharmacology 13: 53–63.

    PubMed  CAS  Google Scholar 

  14. Abood, L. G., Lowy, K., Tometsko, A., and Booth, H., 1978, J. Neurosci. Res. 3: 327–333.

    PubMed  CAS  Google Scholar 

  15. Yoshida, K., and Imura, H., 1979, Brain Res. 172: 453–459.

    PubMed  CAS  Google Scholar 

  16. Vincek, W. C., Martin, B. R., Aceto, M. D., and Bowman, E. R., 1980, J. Med. Chem. 23: 960–962.

    PubMed  CAS  Google Scholar 

  17. Romano, C., and Goldstein, A., 1980, Science 210: 647–650.

    PubMed  CAS  Google Scholar 

  18. Sershen, H., Reith, M. E. A., Lajtha, A., and Gennaro, J., Jr., 1981, J. Receptor Res. 2: 115.

    Google Scholar 

  19. Marks, M. J., and Collins, A. C., 1982, Mol. Pharmacol. 22: 554–564.

    PubMed  CAS  Google Scholar 

  20. Beckett, A. H., and Triggs, E. J., 1966, Nature 211: 1415–1419.

    PubMed  CAS  Google Scholar 

  21. Feyerabend, C., and Russell, M. A. H., 1979, J. Pharm. Pharmacol. 31: 73–76.

    PubMed  CAS  Google Scholar 

  22. Maskarinec, M. P., Harvey, R. W., and Caton, J. E., 1978, J. Anal. Toxicol. 2: 124–126.

    CAS  Google Scholar 

  23. Piade, J. J., and Hoffman, D., 1980, J. Liquid Chromatogr. 3: 1505–1515.

    CAS  Google Scholar 

  24. Hartvig, P., Ahnfelt, N.-O., Hammarlund, M., and Vessman, J., 1979, J. Chromatogr. 173: 127–138.

    PubMed  CAS  Google Scholar 

  25. Feyerbend, C., Levitt, T., and Russell, M. A. H., 1975, J. Pharm. Pharmacol. 27: 434–437.

    Google Scholar 

  26. Castro, A., Monji, N., Malkus, H., Eisenhart, W., McKennis, H., Jr., and Bowman, E. R., 1979, Clin. Chini. Acta 95: 473–481.

    CAS  Google Scholar 

  27. Turner, D. M., 1969, Biochem. J. 115: 889–896.

    PubMed  CAS  Google Scholar 

  28. Turner, D. M., 1971, Br. J. Pharmacol. 41: 521–529.

    PubMed  CAS  Google Scholar 

  29. Turner, D. M., 1975. Xenobiotica 9: 553–561.

    Google Scholar 

  30. Miller, R. P., Rotenberg, K. S., and Adir, J., 1977, Drug Metab. Dispos. 5: 436–443.

    PubMed  CAS  Google Scholar 

  31. McKennis, H., Jr., Turnbull, L. B.. Schwartz, S. L., Tamaki, E., and Bowman, E. R., 1962, J. Biol. Chem. 237: 541–546.

    CAS  Google Scholar 

  32. Oldendorf, W., Braun, L., and Cornford, E.. 1979, Stroke 10: 577–581.

    PubMed  CAS  Google Scholar 

  33. Oldendorf, W. H., 1974, Proc. Soc. Exp. Biol. Med. 147: 813–816.

    PubMed  CAS  Google Scholar 

  34. Yamamoto, I., Inoki, R., and Iwatsubo, K., 1968, Toxicol. Appl. Pharmacol. 12: 560–565.

    CAS  Google Scholar 

  35. Turner, D. M., 1969, Biochem. J. 115: 889–893.

    PubMed  CAS  Google Scholar 

  36. Sershen, H., and Lajtha, A., 1979, J. Neurosci. Res. 4: 85–91.

    PubMed  CAS  Google Scholar 

  37. Spector, R., and Goldberg, M. J., 1982, J. Neurochem. 38: 594–596.

    PubMed  CAS  Google Scholar 

  38. Leeds, J., and Turner, D., 1977. Biochem. Pharmacol. 26: 1631–1635.

    PubMed  CAS  Google Scholar 

  39. Balfour, D. J. K.. 1980. Arch. Int. Pharmacodyn. Ther. 245: 95–103.

    PubMed  CAS  Google Scholar 

  40. Balfour, D. J. K., Khullar, A. K., and Longden, A., 1975, Pharmacol. Biochem. Behay. 3: 179–184.

    CAS  Google Scholar 

  41. Turner, D. M., 1975, Res. Commun. Chem. Pathol. Pharmacol. 12: 645–655.

    PubMed  CAS  Google Scholar 

  42. Benwell, M. E. M., and Balfour, D. J. K., 1979, Psychopharmacology 63: 7–11.

    PubMed  CAS  Google Scholar 

  43. Rowell, P. P., Hurst, H. E., Marlowe, C., and Bennett, B. D., 1983, J. Pharmacol. Methods 9: 249–261.

    PubMed  CAS  Google Scholar 

  44. Hansson, E., and Schmiterlow, C. G., 1962, J. Pharmacol. Exp. Ther. 137: 91–102.

    PubMed  CAS  Google Scholar 

  45. Russell, M. A. H., and Feyerbend, C., 1978, Drug Metab. Rev. 8: 29–35.

    PubMed  CAS  Google Scholar 

  46. Driscoll, P., and Bättig, K., 1973, Rev. Environ. Health. 1: 113–133.

    Google Scholar 

  47. Morrison, C. F., and Armitage, A. K., 1967, Ann. N.Y. Acad. Sci. 142: 268–276.

    CAS  Google Scholar 

  48. Morrison, C. F., 1967, J. Neuropharmacol. 6: 229–240.

    CAS  Google Scholar 

  49. Pradhan, S. N., 1970, Arch. Int. Pharmacodyn. Ther. 183: 127–138.

    PubMed  CAS  Google Scholar 

  50. Hanson, H. M., Ivester, C. A., and Morton. B. R., 1979, Cigarette Smoking as a Dependence Process (N. A. Krasnegor, ed.), NIDA Research Monograph, National Institute of Drug Abuse, Rockville, Maryland, pp. 1–39.

    Google Scholar 

  51. Domino, E. F., and Olds, M. E., 1968, J. Pharmacol. Ther. 164: 202–211.

    CAS  Google Scholar 

  52. Longo, V. G., Giunta, F., and Scotti de Carolis, A., 1967, Ann. N.Y. Acad. Sci. 142: 159–169.

    CAS  Google Scholar 

  53. Volle, R. L., and Koelle, G. B., 1965, The Pharmacological Basis of Therapeutics (L. S. Goodman and A. Gilman, eds.), Macmillan, New York, pp. 465–474.

    Google Scholar 

  54. Wesnes, K., Warbarton, D. M., and Matz, B., 1983, Neuropsychobiology 9: 41–44.

    PubMed  CAS  Google Scholar 

  55. Wesnes, K., and Warbarton, D. M., 1983, Neuropsychobiology 9: 223–229.

    PubMed  CAS  Google Scholar 

  56. Wesnes, K.. and Warbarton, D. M.. 1983, Neuropsychobiology 9: 154–157.

    PubMed  CAS  Google Scholar 

  57. Lang, N. J., Latiff, A. A., McQueen, A., and Singer, A., 1977, Pharmacol. Biochem. Behan. 7: 65–70.

    CAS  Google Scholar 

  58. Smith, L. A., and Lang, W. J., 1980, Pharmacol. Biochem. Behay. 13: 215–220.

    CAS  Google Scholar 

  59. Griffiths, R. R., Brady, J. V., and Bradford. L. D., 1979, Advances in Behavioral Pharmacology, Volume 2 (T. Thompson and P. B. Dews, eds.), Academic Press, New York, pp. 162–208.

    Google Scholar 

  60. Goldberg, S. R., Spealman, R. D.. and Goldberg, D. M., 1981, Science 214: 573–575.

    PubMed  CAS  Google Scholar 

  61. Dunn, W. L., 1978, International Workshop on Behavioral Effects of Nicotine (K. Bättig, ed.), S. Karger, Basel, pp. 38–55.

    Google Scholar 

  62. Hall, G. H., and Morrison, C. F., 1973, Nature 243: 199–201.

    PubMed  CAS  Google Scholar 

  63. Hutchinson, R. R., and Emley, G. S., 1973, Smoking Behavior: Motives and Incentives (W. L. Dunn, ed.), V. H. Winston, Washington, pp. 171–196.

    Google Scholar 

  64. Driscoll, P., and Bättig, K., 1981, Pharmacol. Biochem. Behay. 14: 175–179.

    CAS  Google Scholar 

  65. Abood, L. G., Lowy, K., Tometsko, A., and MacNeil, M., 1979, Arch. Int. Pharmacodyn. Ther. 237: 213–229.

    PubMed  CAS  Google Scholar 

  66. Abood. L. G., Lowy, K., Tometsko, A., and Booth, H., 1978, Neurosci. Res. 3: 327–333.

    Google Scholar 

  67. DeNoble, V. J., and Carron, L., 1981, Soc. Neurosci. 7: 662.

    Google Scholar 

  68. Caulfield, M. P., and Higgins. G. A., 1983, Neuropharrnacology 22: 347–351.

    CAS  Google Scholar 

  69. Phan, D. V., Doda, M., Bite, A., and Gyorgy, L., 1973, Acta Physiol. Acad. Sci. Hung. 1: 85–93.

    Google Scholar 

  70. Mattila, M. J., Ahtee, L., and Saarnivaara, L., 1977, Psychopharmacology 52: 7–15.

    Google Scholar 

  71. Sahley, T. L., and Bernston, G. G., 1979, Psychopharmacology 65: 279–283.

    PubMed  CAS  Google Scholar 

  72. Brodie, B. B., and Hogben, A. M., 1957, J. Pharm. Pharmacol. 9: 345–380.

    PubMed  CAS  Google Scholar 

  73. Tripathi, H. M., Martin, B. R., and Aceto, M. D., 1982, J. Pharmacol. Exp. Ther. 221: 9196.

    Google Scholar 

  74. Hughes, J., Kosterlitz, H. W., and Leslie, F. M., 1975, Br. J. Pharmacol. 242: 414–420.

    Google Scholar 

  75. Aceto, M. D., and Harris, L. S., 1981, Psychopharmacology of Clonidine (H. Lal and S. Fielding, eds.), Alan R. Liss, New York, pp. 243–256.

    Google Scholar 

  76. Bernston, G. G., and Berson, B. S., 1980, Life Sci. 26: 455–459.

    Google Scholar 

  77. Krivoy, W. A., Zimmerman, E., and Lande, S., 1974, Proc. Natl. Acad. Sci. 71: 1852–1856.

    PubMed  CAS  Google Scholar 

  78. Bovet, D., Bovet-Nitti, F., and Oliverio, A., 1967, Ann. N.Y. Acad. Sci. 142: 261–267.

    CAS  Google Scholar 

  79. Bättig, K., Driscoll, P., Schlatter, J., and Uster, H. J., 1976, Pharmacol. Biochem. Behay. 4: 435–439.

    Google Scholar 

  80. Schlatter, J., and Bättig, K., 1979, Psychopharmacology 64: 155–161.

    PubMed  CAS  Google Scholar 

  81. Morrison, C. F., 1967, J. Neuropharmacol. 6: 229–235.

    CAS  Google Scholar 

  82. Carr, L. A., and Moore, K. E., 1970, Biochem. Pharmacol. 19: 2361–2374.

    PubMed  CAS  Google Scholar 

  83. Balfour, D. J. K., 1973, Ear. J. Pharmacol. 23: 19–26.

    CAS  Google Scholar 

  84. Glowinski. J., and Axelrod, J., 1965, J. Pharmacol. Exp. Ther. 149: 43–47.

    Google Scholar 

  85. Carlsson, A., Lindqvist, M., Dahlstrom, A., Fuxe, K.. and Masuoka, D., 1965, J. Pharm. Pharmacol. 17: 521–527.

    PubMed  CAS  Google Scholar 

  86. Flood, J. F., Bennett, E. L., Orme, A. E., Rosenzweig, M. R., and Jarvik, M. E., 1978, Science 199: 324–326.

    PubMed  CAS  Google Scholar 

  87. Flood, J. F., Jarvik, M. E., Bennett, E. L., Orme, A. E., and Rosenzweig, M. R., 1977, Behay. Biol. 20: 168–183.

    CAS  Google Scholar 

  88. Sershen, H., Reith, M. E. A., and Lajtha, A., 1982, Brain Res. 251: 183–185.

    PubMed  CAS  Google Scholar 

  89. Armitage, A. K., Hall, G. H.. and Morrison, C. F., 1968, Nature 217: 331–334.

    PubMed  CAS  Google Scholar 

  90. Chiou, C. Y., Long, J. P., Potrepka, R., and Spratt, J. L., 1970, Arch. Int. Pharmacodyn. Ther. 187: 88–96.

    PubMed  CAS  Google Scholar 

  91. Balfour, D. J. K., 1982, Pharmacol. Ther. 16: 269–282.

    PubMed  CAS  Google Scholar 

  92. Chang, P.-L., Bhagat, B., and Taylor, J. J., 1973, Brain Res. 54: 75–84.

    PubMed  CAS  Google Scholar 

  93. Larsson, P.-A., Dahlstrom, A., Heiwall, P.-O., and Booj, S., 1980, J. Neural Transm. 47: 243–251.

    PubMed  CAS  Google Scholar 

  94. GiOrguieff-Chesselet, M. F., Kernel, M. L., Wandscheer, D., and Glowinski, J., 1979, Life Sci. 25: 1257–1262.

    PubMed  CAS  Google Scholar 

  95. Hall, G. H., and Turner, D. M., 1972, Biochem. Pharmacol. 21: 1829–1838.

    PubMed  CAS  Google Scholar 

  96. Westfall, T. C., 1974, Neuropharmacology 13: 693–700.

    PubMed  CAS  Google Scholar 

  97. Arqueros, L., Naquira, D., and Zunino, E., 1978, Biochem. Pharmacol. 27: 2667–2674.

    PubMed  CAS  Google Scholar 

  98. Lichtensteiger, W., Felix, D., Lienhart, R., and Hefti, F., 1976, Brain Res. 117: 85–103.

    PubMed  CAS  Google Scholar 

  99. Lichtensteiger, W., Felix, D., Hefti, F., and Schlumpf, M., 1979, Electrophysiological Effects of Nicotine (A. Remond and C. Izard, eds.), Elsevier, Amsterdam, pp. 15–30.

    Google Scholar 

  100. Lichtensteiger, W., Hefti, F., Felix, D., Huwyler, T., Melamed, E., and Schlumpf, M., 1982, Neuropharmacology 21: 963–968.

    PubMed  CAS  Google Scholar 

  101. Connelly, M. S., and Littleton, J. M., 1983, J. Neurochem. 41: 1297–1302.

    PubMed  CAS  Google Scholar 

  102. Kumakura, K., Karoum, F., Guideotta, A., and Costa, E., 1980. Nature 283: 489–492.

    PubMed  CAS  Google Scholar 

  103. Kamerling, S. G., Wettstein, J. G., Sloan, J. W., Su, T.-P., and Martin, W. R., 1982, Pharmacol. Biochem. Behay. 17: 733–740.

    CAS  Google Scholar 

  104. Hendry, J. S., Rosecrans, J. A., Hong, J. S., and Bondy, S. C., 1982, Fed. Proc. 41: 4716.

    Google Scholar 

  105. Reaves, T. A., Jr., Liu, H.-M., Qasim, M., and Hayward, J. N., 1978, Soc. Neurosci. Abstr. 4: 353.

    Google Scholar 

  106. Bernston, G. G., and Berson, B. S., 1980, Life Sci. 26: 455–459.

    Google Scholar 

  107. Kelly, P. T., and Luttges, M. W., 1972, Neuropharmacology 11: 889–893.

    PubMed  CAS  Google Scholar 

  108. Hamosh, M., Simon, M. R., and Hamosh, P., 1979, Biol. Neonate 35: 290–297.

    PubMed  CAS  Google Scholar 

  109. Johns, J. M., Louis, T. M., Becker, R. F., and Means, L. W., 1982, Neurobehay. Toxicol. Teratol. 4: 365–369.

    CAS  Google Scholar 

  110. Peters, M. A., and Ngan, L. L. E., 1982, Arch. Int. Pharmacodyn. Ther. 257: 155–167.

    PubMed  CAS  Google Scholar 

  111. Peters, D. A. V., Taub, H., and Tang, S., 1979, Neurobehay. Toxicol. 1: 221–225.

    CAS  Google Scholar 

  112. Sershen, H., Reith, M. E. A., Lajtha, A., and Gennaro, J., Jr. 1981, Neuropharmacology 20: 451–456.

    PubMed  CAS  Google Scholar 

  113. Abood, L. G., Reynolds, D. T., and Bidlack, J. M., 1980, Life Sci. 27: 1307–1314.

    PubMed  CAS  Google Scholar 

  114. Aceto, M. D., and Martin, B. R., 1982, Medicinal Research Review, Volume 2, John Wiley and Sons, New York.

    Google Scholar 

  115. Cheng, Y.-C., and Prusoff, W. H., 1973, Biochem. Pharmacol. 22: 3099–3108.

    PubMed  CAS  Google Scholar 

  116. Schwartz, R. D., McGee, R., Jr., and Kellar, K. J., 1982, Mol. Pharmacol. 22: 56–62.

    PubMed  CAS  Google Scholar 

  117. Abood, L. G., Latham, W., and Grassi, S., 1983, Proc. Natl. Acad. Sci. U.S.A. 80: 3536–3539.

    PubMed  CAS  Google Scholar 

  118. Barnard, E. A., and Dolby, J. 0., 1982, Trends Neurosci. 5: 325–327.

    CAS  Google Scholar 

  119. Norman, R. T., Mehraban, F., Barnard, E. A., and Dolby, J., 1982, Proc. Natl. Acad. Sci. U.S.A. 79: 1321–1325.

    PubMed  CAS  Google Scholar 

  120. Schwartz, R. D., and Kellar, K. J., 1983, Science 202: 214–216.

    Google Scholar 

  121. Marks, M. J., Burch, J. B., and Collins, A. C., 1983, J. Pharmacol. Exp. Ther. 226: 817–825.

    PubMed  CAS  Google Scholar 

  122. Costa, L. G., and Murphy, S. D., 1983, J. Pharmacol. Exp. Ther. 226: 392–397.

    PubMed  CAS  Google Scholar 

  123. Sloan, J. W., Martin, W. R., and Todd, G. D., 1983, Psychopharmacol. Bull. 19: 402–408.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Center for Neurochemistry, The Nathan S. Kline Institute for Psychiatric Research, Wards Island, New York, 10035, USA

    Henry Sershen

Authors
  1. Henry Sershen
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Center for Neurochemistry, Wards Island, New York, USA

    Abel Lajtha

Rights and permissions

Reprints and permissions

Copyright information

© 1985 Springer Science+Business Media New York

About this chapter

Cite this chapter

Sershen, H. (1985). Nicotine. In: Lajtha, A. (eds) Alterations of Metabolites in the Nervous System. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-6740-7_10

Download citation

  • DOI: https://doi.org/10.1007/978-1-4757-6740-7_10

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-6742-1

  • Online ISBN: 978-1-4757-6740-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation