Abstract
Neural systems often serve to transmit information rapidly from one region to another. As such, they are highly responsive to alterations in input, quickly translating these signals into isomorphic changes in distal targets. This is the way in which primary sensory afferent and skeletal motor efferent pathways operate. The prototypical synapse for such systems is the mammalian neuromuscular junction. Here, acetylcholine produces a rapid but transient alteration of membrane conductance, thereby generating a postsynaptic potential of millisecond duration. Transmission at these synapses can operate over a wide range of frequencies and for extended periods of time.
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Zigmond, M.J., Stricker, E.M. (1985). Adaptive Properties of Monoaminergic Neurons. In: Lajtha, A. (eds) Alterations of Metabolites in the Nervous System. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-6740-7_4
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