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Abstract

In neuroscience research, there has been an increasing emphasis on defining the functional synaptic circuitry of discrete neuronal pathways within the central and peripheral nervous system. A classical approach to this issue has relied on electrothermic lesions or knife cuts to ablate cell bodies of origin or transect axons in order to induce orthograde degeneration of a pathway of interest.1,2 For neurochemistry, lesion techniques have led to the determination of biochemical parameters specifically associated with or regulated by defined pathways. Neuroanatomists have exploited these methods to map neuronal projections within the brain by taking advantage of the fact that degenerating axons and terminals react selectively with ammoniacal silver staining techniques.3,4 Physiologists and psychologists have utilized brain lesions to determine the role played by lesioned pathways in the mediation of specific behaviors or physiological events.

Keywords

Excitatory Amino Acid Neurotoxic Effect Kainic Acid Arcuate Nucleus Acidic Amino Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1985

Authors and Affiliations

  • Joseph T. Coyle
    • 1
  1. 1.Division of Child Psychiatry and Departments of Psychiatry, Neuroscience, Pharmacology, and PediatricsThe Johns Hopkins University School of MedicineBaltimoreUSA

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