Redox-Active Therapeutics

  • Ines Batinić-Haberle
  • Júlio S. Rebouças
  • Ivan Spasojević

Table of contents

  1. Front Matter
    Pages i-xxx
  2. L. P. Madhubhani P. Hemachandra, Akshaya Chandrasekaran, J. Andres Melendez, Nadine Hempel
    Pages 51-79
  3. Huy Nguyen, Chandra Srinivasan, Ting-Ting Huang
    Pages 81-102
  4. Bryan G. Allen, Douglas R. Spitz
    Pages 103-124
  5. Ines Batinić-Haberle, Artak Tovmasyan, Ivan Spasojević
    Pages 165-212
  6. Victor Hugo A. Pinto, Nathália K. S. M. Falcão, Jacqueline C. Bueno-Janice, Ivan Spasojević, Ines Batinić-Haberle, Júlio S. Rebouças
    Pages 213-243
  7. Rheal A. Towner, Robert A. Floyd
    Pages 245-264
  8. Susan R. Doctrow, Brian Fish, Karl D. Huffman, Zelmira Lazarova, Meetha Medhora, Jacqueline P. Williams et al.
    Pages 265-285
  9. Ana Maria Da Costa Ferreira, Philippe Alexandre Divina Petersen, Helena Maria Petrilli, Maria Rosa Ciriolo
    Pages 287-309
  10. Jan Lj. Miljkovic, Milos R. Filipovic
    Pages 335-375
  11. Debashree Basudhar, Katrina M. Miranda, David A. Wink, Lisa A. Ridnour
    Pages 377-403
  12. Rebecca E. Oberley-Deegan, James D. Crapo
    Pages 405-431
  13. Paula Lam, Nivedh Dinesh, Xandra O. Breakefield
    Pages 433-450
  14. Ana S. Fernandes, Nuno Saraiva, Nuno G. Oliveira
    Pages 451-467
  15. Kathleen A. Ashcraft, Mark W. Dewhirst
    Pages 469-484

About this book

Introduction

This essential volume comprehensively discusses redox-active therapeutics, focusing particularly on their molecular design, mechanistic, pharmacological and medicinal aspects.  The first section of the book describes the basic aspects of the chemistry and biology of redox-active drugs and includes a brief overview of the redox-based pathways involved in cancer (such as the role of mitochondria, hydrogen peroxide and endogenous antioxidative defenses) and the medical aspects of redox-active drugs, assuming little in the way of prior knowledge. The second section encompasses several major classes of redox-active experimental therapeutics, which include porphyrins, salens, nitrones, and other metal-containing (e.g., Mn, Fe, Cu, Zn, Sb) drugs as either single compounds or formulations with nanomaterials and quantum dots. Subsequent sections and chapters describe more specialized aspects of redox-active therapeutics in clinical disorders, such as cancer, cardiovascular diseases, diabetes, central nervous system injuries, neurodegenerative diseases, pain, radiation injury and radioprotection (such as of brain, lungs, head and neck and erectile function) and neglected diseases (e.g., leishmaniasis). Numerous illustrations, tables and figures enhance and complement the text; extensive references to relevant literature are also included.

 

Redox-Active Therapeutics is an invaluable addition to Springer’s Oxidative Stress in Applied Basic Research and Clinical Practice series.  It is essential reading for researchers, clinicians and graduate students interested in understanding and exploring the Redoxome—the organism redox network—as an emerging frontier in drug design, redox biology and medicine.

Keywords

cancer mitochondria diabetes lung disease metalloporphyrins photodynamic therapy redox-active drugs

Editors and affiliations

  • Ines Batinić-Haberle
    • 1
  • Júlio S. Rebouças
    • 2
  • Ivan Spasojević
    • 3
  1. 1.Duke University School of MedicineDurhamUSA
  2. 2.Universidade Federal da ParaíbaJoão PessoaBrazil
  3. 3.Duke University School of MedicineDurhamUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-319-30705-3
  • Copyright Information Springer International Publishing Switzerland 2016
  • Publisher Name Springer, Cham
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-319-30703-9
  • Online ISBN 978-3-319-30705-3
  • Series Print ISSN 2197-7224
  • Series Online ISSN 2197-7232
  • About this book
Industry Sectors
Biotechnology
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Pharma