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The Ischemic Heart

  • Book
  • © 1998

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Editors:
  1. Seibu Mochizuki

    1. Department of Medicine Aoto Hospital, Jikei University School of Medicine, Tokyo, Japan

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  2. Nobuakira Takeda

    1. Department of Internal Medicine Aoto Hospital, Jikei University School of Medicine, Tokyo, Japan

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  3. Makoto Nagano

    1. Jikei University School of Medicine, Tokyo, Japan

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  4. Naranjan S. Dhalla

    1. MRC Group in Experimental Cardiology Institute of Cardiovascular Sciences St. Boniface General Hospital Research Centre Faculty of Medicine, University of Manitoba, Winnipeg, Canada

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Part of the book series: Progress in Experimental Cardiology (PREC, volume 1)

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Table of contents (45 chapters)

  1. Front Matter

    Pages i-xlvi
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  2. Pathophysiologic Mechanisms of Ischemia-Reperfusion Injury

    1. Front Matter

      Pages 1-1
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    2. Function of Cardiac Myocytes in Ischemicheart Disease: Comparative Changes in Right and Left Ventricular Cells

      • Sian E. Harding, Federica del Monte, Philip A. Poole-Wilson
      Pages 3-12

    3. Remodeling of Cardiac Myocytes in Chronic Heart Disease

      • A. Martin Gerdes
      Pages 13-22

    4. Hibernating Myocardium

      • Roberto Ferrari
      Pages 23-31

    5. Length-Dependent Modulation of Cardiac Muscle Contractility in Normoxia, Hypoxia, and Acidosis: Possible Implications for Ischemia

      • Kenichi Hongo, Ed White, Clive H. Orchard
      Pages 33-40

    6. Roles of Superoxide, Nitric Oxide, and Peroxynitrite in Various Pathological Conditions

      • Hideyuki Ishida, Minhaz Uddin Mohammed, Zhi Su, Minako Fujishima, Hiroe Nakazawa
      Pages 41-56

    7. Real-Time Measurement of Nitric Oxide in Coronary Outflow during Transient Myocardial Ischemia and Reperfusion

      • Yoshiaki Fukuhiro, Seiichi Mochizuki, Masami Goto, Takashi Fujiwara, Taiji Murakami, Hiroshi Inada et al.
      Pages 57-65

    8. Production of Hydrogen Peroxide During Hypoxia-Reoxygenation in Isolated Myocytes

      • Ryuji Ueda, Noburu Konno, Masaki Nakatani, Toshiki Iwata, Yoshihisa Arata, Katsumiti Iijima et al.
      Pages 67-76

    9. Oxygen Free Radicals Enhance Ergonovine-Induced Canine Coronary Vasoconstriction

      • Taku Konno, Taku Matsubara, Shoichi Imai, Mikio Nakazawa, Yutaka Yoshida, Tomoyuki Hori et al.
      Pages 77-86

    10. Structure and Expression of Calponin in Arterial Smooth Muscle Cells

      • Hisako Yamamura, Wataru Ikeda, Nobuhiko Shibata, Nobuhisa Awata, Katsuhito Takahashi
      Pages 87-95

    11. Status of β-Adrenoceptors, G-Proteins, and Adenylyl Cyclase in Ischemic Heart Disease

      • Naranjan S. Dhalla, Sujata Persad, Vincenzo Panagia, Sebu Mochizuki, Robert E. Beamish
      Pages 97-123

    12. Oxygen Consumption and Mitochondrial Membrane Potential in Postischemic Myocardium

      • Kazuaki Nishio, Noburu Konno, Yoshihisa Arata, Ryuji Ueda, Katumiti Iijima, Toshiki Iwata et al.
      Pages 125-135

    13. Pathophysiological Behavior of the Myocardium in Acute Ischemia and Reperfusion, with Special Emphasis on the Sarcoplasmic Reticulum

      • Takashi Katagiri, Eiichi Geshi, Hirohisa Arata, Haruhiko Ishioka, Seiji Itoh, Noburu Konno
      Pages 137-149

    14. Ca2+ Ion Shifts in Vivo in Reversible and Irreversible Ischemic Injury

      • Robert B. Jennings, Charles Steenbergen
      Pages 151-176

    15. Ionic Mechanisms of Reperfusion Injury

      • Michael J. Shattock
      Pages 177-188

    16. Mechanism of Inhibition of Na+-H+ Exchanger (NHE1) by ATP Depletion: Implications for Myocardial Ischemia

      • Toshitaro Ikeda, Shigeo Wakabayashi, Munekazu Shigekawa
      Pages 189-197

    17. The Source and Fate of Protons in the Reperfused Ischemic Heart

      • Gary D. Lopaschuk, Alexander S. Clanachan
      Pages 199-213

    18. Intracellular Calcium Regulation in Cardiac Cells during Acidosis

      • Cesare M. N. Terracciano, Kenneth T. Macleod
      Pages 215-240

    19. Intracellular pH Regulation and Myocardial Ischemia-Reperfusion Injury

      • Danielle Feuvray
      Pages 241-247
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Keywords

About this book

Over the past three decades, impressive progress in the field of pathogenesis, prevention and therapy of ischemic heart disease has resulted in a marked decline in mortality in the Western World. However, the incidence of this devastating disease is on the rise in developing countries.
The Ischemic Heart is based upon a recent symposium in Tokyo on the subject. This volume is organized into two sections: (i) Pathophysiologic Mechanisms of Ischemia-Reperfusion Injury and (ii) Preconditioning and Protection of Ischemia-Reperfusion Injury, and contains up-to-date information concerning the current concepts of ischemia-reperfusion injury, the sequence of events resulting in the loss of contractile dysfunction, and mechanisms of cardioprotection by several drugs as well as the role of ischemic preconditioning in attenuating problems associated with ischemia-reperfusion injury.

Editors and Affiliations

  • Department of Medicine Aoto Hospital, Jikei University School of Medicine, Tokyo, Japan

    Seibu Mochizuki

  • Department of Internal Medicine Aoto Hospital, Jikei University School of Medicine, Tokyo, Japan

    Nobuakira Takeda

  • Jikei University School of Medicine, Tokyo, Japan

    Makoto Nagano

  • MRC Group in Experimental Cardiology Institute of Cardiovascular Sciences St. Boniface General Hospital Research Centre Faculty of Medicine, University of Manitoba, Winnipeg, Canada

    Naranjan S. Dhalla

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