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The Source and Fate of Protons in the Reperfused Ischemic Heart

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The Ischemic Heart

Part of the book series: Progress in Experimental Cardiology ((PREC,volume 1))

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Abstract

Metabolic modulation (i.e., optimizing the energy substrate preference by the heart during and following ischemia) is an exciting new approach to treating ischemic heart disease. However, the relationship between glucose metabolism and alterations in proton production and clearance during and following ischemia remains poorly understood. It is clear, however, that the recovery of mechanical function and cardiac efficiency in the reperfused postischemic heart is influenced by both the source and fate of protons. Inhibition of the source of protons during ischemia and/or reperfusion by improving the coupling between glycolysis and glucose oxidation will increase the rate of recovery of pHi and improve recovery of mechanical function and efficiency. Modulation of the fate of protons will also affect pHi, but the consequences on function and efliciency will depend on the specific pathway by which the protons are cleared.

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Authors and Affiliations

  1. Cardiovascular Disease Research Group, University of Alberta, Canada

    Gary D. Lopaschuk & Alexander S. Clanachan

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  1. Gary D. Lopaschuk
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Editors and Affiliations

  1. Department of Medicine Aoto Hospital, Jikei University School of Medicine, Tokyo, Japan

    Seibu Mochizuki M.D., Ph.D. (Professor and Chairman) (Professor and Chairman)

  2. Department of Internal Medicine Aoto Hospital, Jikei University School of Medicine, Tokyo, Japan

    Nobuakira Takeda M.D., Ph.D. (Associate Professor) (Associate Professor)

  3. Jikei University School of Medicine, Tokyo, Japan

    Makoto Nagano M.D., Ph.D. (Professor-Emeritus) (Professor-Emeritus)

  4. MRC Group in Experimental Cardiology Institute of Cardiovascular Sciences St. Boniface General Hospital Research Centre Faculty of Medicine, University of Manitoba, Winnipeg, Canada

    Naranjan S. Dhalla Ph.D., M.D. (Hon.), D.Sc. (Hon.) (Distinguished Professor and Director) (Distinguished Professor and Director)

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Lopaschuk, G.D., Clanachan, A.S. (1998). The Source and Fate of Protons in the Reperfused Ischemic Heart. In: Mochizuki, S., Takeda, N., Nagano, M., Dhalla, N.S. (eds) The Ischemic Heart. Progress in Experimental Cardiology, vol 1. Springer, Boston, MA. https://doi.org/10.1007/978-0-585-39844-0_16

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  • DOI: https://doi.org/10.1007/978-0-585-39844-0_16

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