The Source and Fate of Protons in the Reperfused Ischemic Heart

  • Gary D. Lopaschuk
  • Alexander S. Clanachan
Part of the Progress in Experimental Cardiology book series (PREC, volume 1)


Metabolic modulation (i.e., optimizing the energy substrate preference by the heart during and following ischemia) is an exciting new approach to treating ischemic heart disease. However, the relationship between glucose metabolism and alterations in proton production and clearance during and following ischemia remains poorly understood. It is clear, however, that the recovery of mechanical function and cardiac efficiency in the reperfused postischemic heart is influenced by both the source and fate of protons. Inhibition of the source of protons during ischemia and/or reperfusion by improving the coupling between glycolysis and glucose oxidation will increase the rate of recovery of pHi and improve recovery of mechanical function and efficiency. Modulation of the fate of protons will also affect pHi, but the consequences on function and efliciency will depend on the specific pathway by which the protons are cleared.


Fatty Acid Oxidation Glucose Oxidation Proton Production Cardiac Efficiency Reperfused Ischemic Heart 


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Copyright information

© Kluwer Academic Publishers 1998

Authors and Affiliations

  • Gary D. Lopaschuk
    • 1
  • Alexander S. Clanachan
    • 1
  1. 1.Cardiovascular Disease Research GroupUniversity of AlbertaCanada

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