Length-Dependent Modulation of Cardiac Muscle Contractility in Normoxia, Hypoxia, and Acidosis: Possible Implications for Ischemia

  • Kenichi Hongo
  • Ed White
  • Clive H. Orchard
Part of the Progress in Experimental Cardiology book series (PREC, volume 1)


The results discussed in this chapter suggest that the stretch-dependent increase in cardiac contraction is inhibited during hypoxia and modulated during acidosis. In ischemia, both hypoxia and acidosis occur simultaneously, so the length-dependent changes in cardiac contractility during ischemia would be a function of the changes in both conditions. The increase in cardiac contractility observed following muscle stretch might be inhibited during ischemia, possibly by altered Ca2+ handling and a decreased Ca2+sensitivity of the myofilaments. Thus, the contractile changes in the response to stretch observed in the present study during hypoxia and acidosis may modulate the contractile response of cardiac muscle to ischemia.


Cardiac Muscle Slow Phase Slow Increase Muscle Length Sarcomere Length 
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  1. 1.
    Lakatta EG. 1992. Length modulation of muscle performance. Frank-Starling law of the heart. In Fozzard HA (ed), The Heart and Cardiovascular System, 2nd ed. New York Raven, pp. 1325–1351.Google Scholar
  2. 2.
    Lederer WJ, Nichols CG, Smith GL. 1989. The mechanism of early contractile failure of isolated rat ventricular myocytes subjected to complete metabolic inhibition. J Physiol 413:329–349.PubMedGoogle Scholar
  3. 3.
    Stern MD, Silverman HS, Houser SR, Josephson RA, Capogrossi MC, Nichols CG, Lederer WJ, Lakatta EG. 1988. Anoxic contractile failure in rat heart myocytes is caused by failure of intracellular calcium release due to alteration of the action potential. Proc Natl Acad Sci USA 85:6954–6958.PubMedCrossRefGoogle Scholar
  4. 4.
    Allen DG, Morris PG, Orchard CH, Pirolo JS. 1985. A nuclear magnetic resonance study of metabolism in the ferret heart during hypoxia and inhibition of glycolysis. J Physiol 361:185–204.PubMedGoogle Scholar
  5. 5.
    Elliott AC, Smith GL, Eisner DA, Allen DG. 1992. Metabolic changes during ischaemia and their role in contractile failure in isolated ferret hearts. J Physiol 454:467–490.PubMedGoogle Scholar
  6. 6.
    Allen DG, Lee JA, Smith GL. 1989. The consequences of simulated ischaemia on intracellular Ca2+ and tension in isolated ferret ventricular muscle. J Physiol 410:297–323.PubMedGoogle Scholar
  7. 7.
    Allen DG, Orchard CH. 1983. Intracellular calcium concentration during hypoxia and metabolic inhibition in mammalian ventricular muscle. J Physiol 339:107–122.PubMedGoogle Scholar
  8. 8.
    Allen DG, Orchard CH. 1987. Myocardial contractile function during ischemia and hypoxia. Circ Res 60:153–168.PubMedGoogle Scholar
  9. 9.
    Orchard CH, Kentish JC. 1990. Effects of changes of pH on the contractile function of cardiac muscle. Am J Physiol 258 (Cell Physiol 27): C967–C981.PubMedGoogle Scholar
  10. 10.
    Allen DG, Kurihara S. 1982. The effects of muscle length on intracellular calcium transients in mammalian cardiac muscle. J Physiol 327:79–94.PubMedGoogle Scholar
  11. 11.
    Hongo K, White E, Orchard CH. 1995. The effect of stretch on contraction and the Ca2+ transient in ferret ventricular muscles during hypoxia and acidosis. Am J Physiol 269:C690–C697.PubMedGoogle Scholar
  12. 12.
    Allen DG, Nichols CG, Smith GL. 1988. The effects of changes in muscle length during diastole on the calcium transient in ferret ventricular muscle. J Physiol 406:359–370.PubMedGoogle Scholar
  13. 13.
    Marban E, Kusuoka H. 1987. Maximal Ca2+-activated force and myofilaments Ca2+ sensitivity in intact mammalian hearts. J Gen Physiol 90:609–623.PubMedCrossRefGoogle Scholar
  14. 14.
    Smith GL, Steele DS. 1992. Inorganic phosphate decreases the Ca2+ content of the sarcoplasmic reticulum in saponin-treated rat cardiac trabeculae. J Physiol 458:457–473.PubMedGoogle Scholar
  15. 15.
    Allen DG, Orchard CH. 1983. The effects of changes of pH on intracellular calcium transients in mammalian cardiac muscle. J Physiol 335:555–567.PubMedGoogle Scholar
  16. 16.
    Fabiato A, Fabiato F. 1978. Effects of pH on the myofilaments and the sarcoplasmic reticulum of skinned cells from cardiac and skeletal muscles. J Physiol 276:233–255.PubMedGoogle Scholar
  17. 17.
    Ricciardi L, Bucx JJJ, ter Keurs HEDJ. 1986. Effects of acidosis on force—sarcomere length and force-velocity relations of rat cardiac muscle. Cardiovasc Res 20:117–123.PubMedCrossRefGoogle Scholar
  18. 18.
    Hibberd MG, Jewell BR. 1982. Calcium-and length-dependent force production in rat ventricular muscle. J Physiol 329:527–540.PubMedGoogle Scholar

Copyright information

© Kluwer Academic Publishers 1998

Authors and Affiliations

  • Kenichi Hongo
    • 1
  • Ed White
    • 2
  • Clive H. Orchard
    • 2
  1. 1.The Jikei University School of MedicineJapan
  2. 2.University of LeedsUK

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