Overview
- Editors:
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Isabelle Vernos
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European Molecular Biology Laboratory, Heidelberg, Germany
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Table of contents (20 protocols)
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- Sergei A. Kuznetsov, Vladimir I. Gelfand
Pages 1-7
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- Laura M. Ginkel, Linda Wordeman
Pages 21-41
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- Maryanne F. Stock, David D. Hackney
Pages 43-48
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- Kimberly W. Waligora, Sharyn A. Endow
Pages 49-55
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- Nobutaka Hirokawa, Yasuko Noda
Pages 57-63
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- David D. Hackney, Wei Jiang
Pages 65-71
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- Sylvia Jeney, Ernst-Ludwig Florin, J. K. Heinrich Hörber
Pages 91-108
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- Arshad Desai, Claire E. Walczak
Pages 109-121
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- Erik Nielsen, Fedor Severin, Anthony A. Hyman, Marino Zerial
Pages 133-146
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- Gerardo Morfini, Ming-Ying Tsai, Györgyi Szebenyi, Scott T. Brady
Pages 147-162
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- Robert L. Morris, Heather M. Brown, Brent D. Wright, David J. Sharp, William Sullivan, Jonathan M. Scholey
Pages 163-172
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- Haralabia Boleti, Eric Karsenti, Isabelle Vernos
Pages 173-189
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- Vladimir I. Gelfand, Nathalie Le Bot, M. Carolina Tuma, Isabelle Vernos
Pages 191-204
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- Lisa C. Lindesmith, Janardan Kumar, Michael P. Sheetz
Pages 205-212
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- François Nédélec, Thomas Surrey
Pages 213-222
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- Manfred Thormählen, Jens Müller, Eckhard Mandelkow
Pages 223-233
About this book
By the end of the 1980s only two microtubule-dependent motors, the plus end-directed kinesin and the minus end-directed cytoplasmic dynein, had been identified. At the time, these two motors seemed almost sufficient to explain directional motility events on polar microtubule tracks in the cell. No- theless, shortly after, the tip of the iceberg began to emerge with the identi- cation of proteins containing in their sequences a domain found in kinesin. This domain, called the “motor domain,” conferred on these proteins the essential property of moving on microtubules, using the energy derived from ATP hydro- sis. Since then, the identification of new proteins belonging to the kinesin superfamily of microtubule-dependent motors has gone at such a pace that nowadays more than 200 entries with motor domain sequences are deposited in the database. Kinesin family members are found in all eukaryotic org- isms tested. They present a wide range of domain organizations with a motor domain located at different positions in the molecule. Their motility prop- ties are also variable in directionality, velocity, and such other characteristics as bundling activity and processivity. Finally, and most important, they p- ticipate in a multitude of cellular functions. Our understanding of many cel- lar events, such as mitotic spindle assembly and neuronal transport, to cite only two, has progressed substantially in the last few years thanks to the id- tification of these motors.
Reviews
"This is a concise but comprehensive book that would be a valuable reference for any researcher who wishes to study this important cytoplasmic motor protein. It would be a valuable book to have in the laboratory as well as a useful reference book in a life sciences library. "-Doody's Health Sciences Book Review Journal
Editors and Affiliations
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European Molecular Biology Laboratory, Heidelberg, Germany
Isabelle Vernos
