Abstract
The mitotic spindle is a transient cellular structure that distributes faithfully the chromosomes among the two daughter cells during mitosis. This highly dynamic bipolar structure assembles and disassembles periodically and its main structural components are microtubules (MTs) and chromosomes. Microtubule-dependent motors in particular members of the kinesin superfamily play an important role in directing the self-organization of microtubules into a bipolar spindle.
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Boleti, H., Karsenti, E., Vernos, I. (2001). The Use of Dominant Negative Mutants to Study the Function of Mitotic Motors in the In Vitro Spindle Assembly Assay in Xenopus Egg Extracts. In: Vernos, I. (eds) Kinesin Protocols. Methods in Molecular Biology™, vol 164. Humana Press. https://doi.org/10.1385/1-59259-069-1:173
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DOI: https://doi.org/10.1385/1-59259-069-1:173
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