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Physiology and Pathophysiology of the Islets of Langerhans

  • Book
  • © 1997

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Editors:
  1. Bernat Soria

    1. Miguel Hernandez University, Alicante, Spain

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Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 426)

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Table of contents (59 chapters)

  1. β-Cell Heterogeneity: Building an Homogeneous Response from an Heterogeneous Population

    1. Heterogeneity of β-Cell Ca2+ Responses to Glucose

      • P. Smith, P. J. Millard, C. M. S. Fewtrell, F. M. Ashcroft
      Pages 253-257

    2. Glucose-Induced B-Cell Recruitment and the Expression of Hexokinase Isoenzymes

      • Frans C. Schuit, Anick De Vos, Karen Moens, Erik Quartier, Harry Heimberg
      Pages 259-266

    3. Physiological Behavior of Functional Subpopulations of Single Pancreatic β-Cells

      • Marcia Hiriart, Ma. Teresa Martinez, Ma. del Carmen Ramírez-Medeles
      Pages 267-274

    4. Computer Modeling of Heterogeneous β-Cell Populations

      • Arthur Sherman, Paul Smolen
      Pages 275-284

    5. Reconstructing Islet Function In Vitro

      • Domenico Bosco, Paolo Meda
      Pages 285-298

  2. IDDM (Insulin Dependent Diabetes Mellitus): What Went Wrong? Mechanisms of β-Cell Destruction and Defense

    1. Front Matter

      Pages 299-299
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    2. New Aspects to the Functioning and Regeneration of Pancreatic β-Cells

      • Hiroshi Okamoto
      Pages 301-311

    3. A Role for Nitric Oxide and Other Inflammatory Mediators in Cytokine-Induced Pancreatic β-Cell Dysfunction and Destruction

      • Michael L. McDaniel, John A. Corbett, Guim Kwon, Jeanette R. Hill
      Pages 313-319

    4. The Reg Gene and Islet Cell Repair and Renewal in Type 1 Diabetes

      • Adrian J. Bone, Susan H. Banister, Shaoli Zhang
      Pages 321-327

    5. DNA-Damage and NAD+-Depletion are Initial Events in Oxygen Radical Induced Islet Cell Death

      • B. Heller, A. Bürkle, J. Radons, E. Fengler, M. Müller, V. Burkart et al.
      Pages 329-334

    6. Nitric Oxide Rather than Superoxide or Peroxynitrite Inhibits Insulin Secretion and Causes DNA Damage in HIT-T15 Cells

      • C. A. Delaney, J. M. Cunningham, M. H. L. Green, I. C. Green
      Pages 335-339

    7. Activation of Peritoneal Macrophages During the Prediabetic Phase in Low-Dose Streptozotocin-Treated Mice

      • Josefa Andrade, Manuel Conde, Francisco Sobrino, Francisco J. Bedoya
      Pages 341-343

    8. Immunological Reactivity of Diabetes-Prone BB/OK Rats to Syngeneic Antigens

      • Dieter Schröder, Siegfried Schmidt, Ingrid Klöting, Anke Honig, Silke Lucke, Bernd Hehmke et al.
      Pages 345-353

    9. Effects of Oxidants on Membrane Potential, K+ and Ca2+ Currents of Mouse Pancreatic B-Cells

      • Peter Krippeit-Drews, Stefan Britsch, Florian Lang, Gisela Drews
      Pages 355-359

  3. Pathophysiology of the NIDDM

    1. Front Matter

      Pages 361-361
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    2. IAPP and Insulin Regulation in Human Pancreatic Islets

      • A. Novials, R. Gasa, J. Fernandez-Alvarez, R. Gomis
      Pages 363-369

    3. Hyperproinsulinaemia and Islet Dysfuction in the NIDDM-Like Syndrome of Psammomys obesus

      • Nurit Kaiser, Michal Gadot, Gil Leibowitz, Erol Cerasi, David J. Gross
      Pages 371-378

    4. Altered Secretory Responsiveness of Brin-BD11 Cells Cultured under Hyperglycaemic Conditions is not Readily Reversed by Subsequent Culture in Lower Glucose Concentrations

      • Alison M. Wilson, Christopher R. Barnett, Peter R. Flatt
      Pages 379-384

    5. B-Cell Hyperresponsiveness to Glucose in NIDDM During Prediabetes

      • Yoshihiko Sato, Fujiki Ishihara, Kiyoshi Hashizume, Toru Aizawa
      Pages 385-387

    6. Insulin Treatment Prevents Adaptation of the Endocrine Pancreas to Pregnancy

      • T. R. Koiter, S. Wijkstra, H. Moes, G. C. J. van der Schaaf-Verdonk
      Pages 389-393
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Editors and Affiliations

  • Miguel Hernandez University, Alicante, Spain

    Bernat Soria

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