Abstract
One of the characteristic features of type 2 diabetes is the presence of extracellular deposition of amyloid in the islets of Langerhans (1). The storage of amyloid is characteristic of several animal species, i.e. humans, cats, and monkeys (2,3). The principal component of islet amyloid is a peptide designated as islet amyloid polypeptide (IAPP) or amylin, which is synthesized and stored in beta cells (4). In vivo and in vitro experiments in rats have shown that IAPP is coreleased with insulin in a regulated manner after different secretagogue stimulus (5).
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© 1997 Springer Science+Business Media New York
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Novials, A., Gasa, R., Fernandez-Alvarez, J., Gomis, R. (1997). IAPP and Insulin Regulation in Human Pancreatic Islets. In: Soria, B. (eds) Physiology and Pathophysiology of the Islets of Langerhans. Advances in Experimental Medicine and Biology, vol 426. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1819-2_48
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DOI: https://doi.org/10.1007/978-1-4899-1819-2_48
Publisher Name: Springer, Boston, MA
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