Chemical Carcinogenesis

Models and Mechanisms

  • Francesco Feo
  • Paolo Pani
  • Amedeo Columbano
  • Renato Garcea

Table of contents

  1. Front Matter
    Pages i-xv
  2. Xenobiotics: Metabolism and Interaction with Cellular Macromolecules

    1. Front Matter
      Pages 1-1
    2. Harry V. Gelboin, Frank J. Gonzalez, Sang S. Park, Junji Sagara, Narayana Battula
      Pages 3-15
    3. Fred F. Kadlubar, F. Peter Guengerich, Mary Ann Butler, K. Barry Delclos
      Pages 17-23
    4. William M. Baird, Teresa A. Smolarek, Said M. Sebti, Donna Pruess-Schwartz
      Pages 25-36
    5. Hermann M. Bolt, Hans Peter, Rainer Jäger
      Pages 45-51
    6. Giorgio Cantelli-Forti, G. L. Biagi, P. A. Borea, G. Bronzetti, M. C. Guerra, P. Hrelia et al.
      Pages 53-65
    7. Silvio De Flora, Carmelo F. Cesarone, Carlo Bennicelli, Anna Camoirano, Domizio Serra, Monia Bagnasco et al.
      Pages 75-86
    8. Rosa Pascale, Lucia Daino, Maria E. Ruggiu, Maria G. Vannini, Renato Garcea, Serenella Frassetto et al.
      Pages 87-92
    9. Giorgio Prodi, Annamaria Colacci, Sandro Grilli, Giovanna Lattanzi, Mario Mazzullo, Paola Turina
      Pages 93-102
    10. Jamie R. Milligan, Laura Catz-Biro, Samim Hirani-Hojatti, Michael C. Archer
      Pages 111-117
    11. Marco Presta, Marco Rusnati, Jeanette A. M. Maier, Giovanni Ragnotti
      Pages 129-135
    12. Luisa Airoldi, Marina Bonfanti, Cinzia Magagnotti, Roberto Fanelli
      Pages 137-142
    13. Aldo Tomasi, Emanuele Albano, Barbara Botti, Francesco P. Corongiu, M. Assunta Dessì, Anna Iannone et al.
      Pages 143-151
    14. Alessandro F. Casini, Emilia Maellaro, Alfonso Pompella, Marco Ferrali, Mario Comporti
      Pages 153-163
  3. Developmental Stages of Carcinogenesis

    1. Front Matter
      Pages 165-165

About this book

Introduction

About two centuries after the communication by Sir Percival Pott that the "chimney sweeper disease" was a cancer and its suggestion that active compounds of soot were the causative agents, and about one century after the description of urinary bladder cancer in dye workers, an enormous number of substances have been synthesized and have probably come into contact with man. Research in cancer prevention is of primary importance, and may receive continuous support from new discoveries on cancer etiology and pathogenesis. If one accepts the multistage model of chemical carcinogenesis, one has also to accept that many events occur between the contact of carcino­ genic compounds and their specific targets and the development of a clinically recognizable neoplasm. Thus, animal studies become essential to elucidate the different steps by which chemical carcinogens induce neoplasia. The analysis of these steps and the comparative evaluation of experimental models is essential to an understanding of pathogenesis.

Keywords

apoptosis cancer carcinogenesis cell cell culture etiology hormones liver liver tumor mutagen pathogenesis prevention surgery tumor tumorigenesis

Editors and affiliations

  • Francesco Feo
    • 1
  • Paolo Pani
    • 2
  • Amedeo Columbano
    • 2
  • Renato Garcea
    • 1
  1. 1.University of SassariSassariItaly
  2. 2.University of CagliariCagliariItaly

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4757-9640-7
  • Copyright Information Springer-Verlag US 1988
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4757-9642-1
  • Online ISBN 978-1-4757-9640-7
  • About this book
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