Cytochrome P-450 Function Analyses with Monoclonal Antibodies and cDNA Expression Vectors
It is quite fitting and proper to initiate this International Conference devoted to the problems of chemical carcinogenesis with a discussion of the role and function of cytochrome P-450. Cytochrome P-450 is the enzymatic interface between mammalian organisms, including man, and a large variety of foreign chemicals, i.e. xenobiotics, which include almost all chemical carcinogens.
KeywordsAniline Hydroxylase cDNA Expression Vector Microsomal Monooxygenase System Aniline Hydroxylation Drug Nifedipine
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- 8.E. Hietanen, C. Malaveille, F. K. Friedman, S. S. Park, J. C. Bereziat, G. Brun, H. Bartsch and H. V. Gelboin, Monoclonal Antibody-directed Analysis of Cytochrome P-450-dependent Monooxygenases and Mutagen Activation in the Livers of DBA/2 and C57BL/6 Mice, Cancer Res. 46:524 (1986).PubMedGoogle Scholar
- 13.B. J. Song, T. Matsunaga, J. P. Hardwick, S. S. Park, R. L. Veech, C. S. Yang, H. V. Gelboin and F. J. Gonzalez, Stabilization of cytochrome P450J mRNA in teh diabetic rat, Molec. Endocrinol. in press (1987).Google Scholar
- 14.O. W. McBride, M. V. Umeno, H. V. Gelboin and F. J. Gonzalez, A TaqI polymorphysm in the human P450 IIE1 gene on chromosome 10, Nucleic Ac. Res. in press (1987).Google Scholar