Interaction of Activated N-Nitrosamines with DNA

  • Jamie R. Milligan
  • Laura Catz-Biro
  • Samim Hirani-Hojatti
  • Michael C. Archer


Some chemically induced tumors in rodents are associated with single point mutations in ras genes1. It is important to know whether these mutations arise at sites in DNA of unusually high reactivity for ultimate carcinogens, or whether carcinogen interaction is random. This information is not available for simple methylating agents such as those derived from N-nitroso compounds.


Single Point Mutation Plasmid pBR322 Methylating Agent Methyl Phosphate Apurinic Site 
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Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • Jamie R. Milligan
    • 1
  • Laura Catz-Biro
    • 1
  • Samim Hirani-Hojatti
    • 1
  • Michael C. Archer
    • 1
  1. 1.Department of Medical BiophysicsUniversity of Toronto Ontario Cancer InstituteTorontoCanada

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