Cytokine Knockouts

  • Scott K. Durum
  • Kathrin Muegge

Part of the Contemporary Immunology book series (CONTIM)

Table of contents

  1. Front Matter
    Pages i-xxv
  2. Thomas Hünig, Anneliese Schimpl
    Pages 1-19
  3. Ursula von Freeden-Jeffry, Thomas A. Moore, Albert Zlotnik, Richard Murray
    Pages 21-36
  4. Jacques J. Peschon, Brian C. Gliniak, Philip Morrissey, Eugene Maraskovsky
    Pages 37-52
  5. Charles R. Maliszewski, Mary K. Kennedy, Kim A. Campbell
    Pages 53-67
  6. Hans-Pietro Eugster, Matthias Müller, Michel Le Hir, Bernhard Ryffel
    Pages 103-118
  7. Theresa A. Banks
    Pages 119-127
  8. Giamila Fantuzzi, Charles A. Dinarello
    Pages 129-153
  9. Philip J. Morrissey, Moira Glaccum, Charles R. Maliszewski, Jacques Peschon
    Pages 155-171
  10. Keisuke Kuida, Judith A. Lippke, Michael S.-S. Su, Richard A. Flavell
    Pages 173-188
  11. Jan Vilček, Michel Aguet, Luiz F. L. Reis
    Pages 207-225
  12. Alistair J. Ramsay, Manfred Kopf
    Pages 227-236
  13. Kanji Yoshida, Tetsuya Taga, Mikiyoshi Saito, Atsushi Kumanogoh, Takashi Tanaka, Keiichi Ozono et al.
    Pages 259-285
  14. Shizuo Akira, Takashi Tanaka, Tadamitsu Kishimoto
    Pages 287-313
  15. Carol B. Ware, Joan S. Hunt
    Pages 315-334
  16. Suhas Kallapur, Marcia Shull, Thomas Doetschman
    Pages 335-368
  17. Ashok B. Kulkarni, John J. Letterio
    Pages 369-400
  18. Ashley R. Dunn, Graham J. Lieschke
    Pages 401-418
  19. Ryuichi Nishinakamura, Stefan Burdach, Uta Dirksen, Richard Murray
    Pages 419-434
  20. Graham J. Lieschke, Ashley R. Dunn
    Pages 435-456
  21. Mark W. Moore, Frederic J. de Sauvage
    Pages 457-465
  22. Back Matter
    Pages 467-482

About this book


Surveying one of today's most powerful new methodologies, Durum and Muegge assemble in Cytokine Knockouts a unique compendium of the latest information on cytokine knockout mice. Each chapter-written by the leading scientists who created or studied each knockout-illuminates the physiological consequences of deficiency in that cytokine and relates the phenotype to other knockout mice and to human diseases. The effects discussed range from diseases of the bowel, lung, heart, blood, kidney, and liver to immune deficiency, developmental defects, and autoimmunity. Most of the key knockouts of cytokines or receptors, including IL-1 through 8, IFNs, TGFs, TNF, LT, CD40, LIF, CSFs, c-mpl, gp130, and ICE, are thoroughly reviewed.

Cytokine Knockouts' many distinguished contributors crystallize their insights into the role of cytokines in health and disease, explain important new concepts in human and animal diseases, and indicate which cytokines should (and should not) become pharmacological targets. Their
book offers an authoritative synthesis and review of this important new field and will immediately become a standard resource for today's biomedical researchers.


Colon Vivo cytokine cytokines development enzyme enzymes genes immunodeficiency interferon metabolism necrosis placenta platelets receptor

Editors and affiliations

  • Scott K. Durum
    • 1
  • Kathrin Muegge
    • 1
  1. 1.National Cancer InstituteFrederickUSA

Bibliographic information

Industry Sectors
Health & Hospitals
Consumer Packaged Goods