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Functional Phenotype of Mice Deficient in the IL-1R Type I Gene

A Comparison with Other Genetically Modified Mice

  • Chapter
Cytokine Knockouts

Part of the book series: Contemporary Immunology ((CONTIM))

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Abstract

Interleukin 1 (IL-1) is a cytokine that is involved in the mechanism of host resistance and immune function (for review, see ref. 1). Evidence indicates that IL-1 functions as a proinflammatory cytokine with significant and well-documented effects on innate resistance and the inflammatory response (2). The biological effects of IL-1 also influence the development of the specific immune response. IL-1 has been long studied as a costimulator of both B-cells and T-cells and the adjuvant effect of IL-1 is well documented (3–5). Thus, it is believed that IL-1 plays a central role in both innate resistance mechanisms and specific immune responses.

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Authors
  1. Philip J. Morrissey
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  2. Moira Glaccum
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  3. Charles R. Maliszewski
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  4. Jacques Peschon
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Editors and Affiliations

  1. National Cancer Institute, Frederick, MD, USA

    Scott K. Durum  & Kathrin Muegge  & 

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Morrissey, P.J., Glaccum, M., Maliszewski, C.R., Peschon, J. (1998). Functional Phenotype of Mice Deficient in the IL-1R Type I Gene. In: Durum, S.K., Muegge, K. (eds) Cytokine Knockouts. Contemporary Immunology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4757-2753-1_10

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  • DOI: https://doi.org/10.1007/978-1-4757-2753-1_10

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-4757-2755-5

  • Online ISBN: 978-1-4757-2753-1

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