Functional Phenotype of Mice Deficient in the IL-1R Type I Gene

A Comparison with Other Genetically Modified Mice
  • Philip J. Morrissey
  • Moira Glaccum
  • Charles R. Maliszewski
  • Jacques Peschon
Part of the Contemporary Immunology book series (CONTIM)


Interleukin 1 (IL-1) is a cytokine that is involved in the mechanism of host resistance and immune function (for review, see ref. 1). Evidence indicates that IL-1 functions as a proinflammatory cytokine with significant and well-documented effects on innate resistance and the inflammatory response (2). The biological effects of IL-1 also influence the development of the specific immune response. IL-1 has been long studied as a costimulator of both B-cells and T-cells and the adjuvant effect of IL-1 is well documented (3–5). Thus, it is believed that IL-1 plays a central role in both innate resistance mechanisms and specific immune responses.


Mean Fluorescent Intensity Host Resistance Acute Phase Response Specific Immune Response Endotoxic Shock 
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Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • Philip J. Morrissey
  • Moira Glaccum
  • Charles R. Maliszewski
  • Jacques Peschon

There are no affiliations available

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