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CD40 Ligand Knockout Mice

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Cytokine Knockouts

Part of the book series: Contemporary Immunology ((CONTIM))

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Abstract

CD40 is a 50-kDa glycoprotein expressed on B-cells, monocytes, dendritic cells, follicular dendritic cells, thymic epithelial cells, and certain carcinomas (for review, see ref. 1). Its counterstructure, CD40 ligand (CD40L), is a 33-kDa glycoprotein expressed primarily on activated CD4+ T-cells, but also found on CD8+ T-cells, mast cells, basophils (1), and eosinophils (2). CD40L belongs to the tumor necrosis factor (TNF) superfamily (3), members of which stimulate a broad range of biological functions including proliferation, induction of cytokine secretion, and apoptosis (For review, see ref. 4).

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Authors
  1. Charles R. Maliszewski
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  2. Mary K. Kennedy
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  3. Kim A. Campbell
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Editors and Affiliations

  1. National Cancer Institute, Frederick, MD, USA

    Scott K. Durum  & Kathrin Muegge  & 

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Maliszewski, C.R., Kennedy, M.K., Campbell, K.A. (1998). CD40 Ligand Knockout Mice. In: Durum, S.K., Muegge, K. (eds) Cytokine Knockouts. Contemporary Immunology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4757-2753-1_4

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  • DOI: https://doi.org/10.1007/978-1-4757-2753-1_4

  • Publisher Name: Humana Press, Totowa, NJ

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