Interleukin-1β-Deficient Mice

  • Giamila Fantuzzi
  • Charles A. Dinarello
Part of the Contemporary Immunology book series (CONTIM)


There are three members of the interleukin-1 (IL-1) gene family: IL-1α, IL-1β, and IL-1 receptor antagonist (IL-1Ra). IL-1α and IL-1β are agonists and IL-1Ra is a specific receptor antagonist. IL-1α and IL-1β are synthesized as precursor molecules, without leader sequences. The molecular weight of each precursor is 31 kDa. Processing of IL-1α or IL-1β to “mature” forms of 17 kDa requires specific cellular proteases.


Tumor Necrosis Factor Alpha Acute Phase Protein Acute Phase Response Acute Myeloblastic Leukemia Sterile Inflammation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • Giamila Fantuzzi
  • Charles A. Dinarello

There are no affiliations available

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