Cooperation Between the TNF Receptors Demonstrated by TNF Receptor Knockout Mice

  • Eve Shinbrot
  • Mark Moore
Chapter
Part of the Contemporary Immunology book series (CONTIM)

Abstract

Tumor necrosis factor (TNF) is a potent cytokine that mediates many biological events, including proliferation of fibroblasts and T-cells, induction of NF-κB, cytotoxicity, tumor necrosis as well as antiviral, inflammatory, and immunoregulatory responses. TNF has been implicated as a central mediator of septic shock as well as graft-vs-host disease, arthritis, and several autoimmune disorders. There are two related TNF molecules, TNFα (tumor necrosis factor or cachectin) and TNFβ (lymphotoxin). TNFα is produced mainly by T-cells, macrophages, and mast cells, whereas TNFß is produced by activated lymphocytes. TNFα and β mediate their actions by binding to two distinct cell surface receptors, TNF-R1 (55 kDa also known as TNFRβ and TNF-R55) and TNF-R2 (75 kDa, also known as TNFRα, and TNFR-75). Both receptors are found on most cell types.

Keywords

Deficient Mouse Cytoplasmic Domain Tumor Necrosis Factor Receptor Follicular Dendritic Cell Thymocyte Development 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • Eve Shinbrot
  • Mark Moore

There are no affiliations available

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