Overview
- Editors:
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J. Richard Hinchliffe
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University College of Wales, Aberystwyth, Wales, UK
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Juan M. Hurle
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University of Cantabria, Santander, Spain
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Dennis Summerbell
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National Institute for Medical Research, London, UK
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Table of contents (54 chapters)
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The Molecular Basis of Patterning
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Growth and Pattern, Retinoids and Other Factors
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- Dennis Summerbell, Nick Waterson
Pages 151-155
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- Sharon C. Frost, J. Richard Hinchliffe
Pages 157-160
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The Extracellular Matrix and Limb Development
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General
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- Charles W. Archer, Marian Fernandez-Teran, Fiona Craig, Micheal Bayliss
Pages 177-188
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- Matthew A. Critchlow, J. Richard Hinchliffe
Pages 189-202
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- M. A. Ros, J. R. Hinchliffe, D. Macias, J. M. Hurle, M. A. Critchlow
Pages 211-213
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Chondrogenesis
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- Bryan Toole, Shib Banerjee, Raymond Turner, Syeda Munaim, Cheryl Knudson
Pages 215-223
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- Robert A. Kosher, Eileen F. Roark, Stephen E. Gould, Caroline N. D. Coelho
Pages 225-233
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- J. M. Hurle, D. Macias, Y. Gañan, M. A. Ros, M. A. Fernandez-Teran
Pages 249-259
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- Bodo Christ, Hans-Henning Epperlein, Helmut Flöel, Jörg Wilting
Pages 265-271
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- Beate Brand-Saberi, Veit Krenn
Pages 273-284
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About this book
Following pioneering work by Harrison on amphibian limbs in the 1920s and by Saunders (1948) on the apical ridge in chick limbs, limb development became a classical model system for investigating such fundamental developmental issues as tissue interactions and induction, and the control of pattern formation. Earlier international conferences, at Grenoble 1972, Glasgow 1976,and Storrs, Connecticut 1982, reflected the interests and technology of their time. Grenoble was concerned with ectoderm-mesenchyme interaction, but by the time of the Glasgow meeting, the zone of polarizing activity (ZPA) and its role in control of patterning was the dominant theme. Storrs produced the first intimations that the ZPA could be mimicked by retinoic acid (RA), but the diversity of extracellular masrix ~olecules,particularly in skeletogenesis,was the main focus of attention. By 1990, the paradigms had again shifted. Originally, the planners of the ARW saw retinoic acid (as a possible morphogen controlling skeletal patterning), the variety of extracellular matrix components and their roles, and the developmental basis of limb evolution as the leading contemporary topics. However, as planning proceeded, it was clear that the new results emerging from the use of homeobox gene probes (first developed to investigate the genetic control of patterning of Drosophila embryos) to analyse the localised expression of "patterning genes" in limb buds would also be an important theme.
Editors and Affiliations
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University College of Wales, Aberystwyth, Wales, UK
J. Richard Hinchliffe
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University of Cantabria, Santander, Spain
Juan M. Hurle
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National Institute for Medical Research, London, UK
Dennis Summerbell