Abstract
Several theoretical models have been proposed to attempt to elucidate the underlying mechanisms involved in the spatial patterning of skeletal elements in the limb. Here, I briefly compare two such models - reaction diffusion (RD) and mechanochemical (MC) - and highlight their properties and predictions.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsReferences
P. Alberch and E. Gale, Size dependency during the development of the amphibian foot. Colchicine induced digital loss and reduction, J. Embryol. exp. Morphol. 76, 177–197 (1983).
P.K. Maini and M. Solursh, Cellular mechanisms of pattern formation in the developing limb, Int. Rev. Cytology (to appear).
G.F. Oster, J.D. Murray, and A.K. Harris, Mechanical aspects of mesenchymal morphogenesis, J. Embryol. exp. Morphol. 78, 83125 (1983).
G.F. Oster, J.D. Murray, and P.K. Maini, A model for chondrogenic condensations in the developing limb: the role of extracellular matrix and cell tractions, J. Embryol. exp. Morphol. 89, 93–112 (1985).
G.F. Oster, N. Shubin, J.D. Murray, and P. Alberch, Evolution and morphogenetic rules. The shape of the vertebrate limb in ontogeny and phylogeny, Evolution 45, 862–884 (1988).
G.F. Oster and J.D. Murray, Pattern formation models and developmental constraints, in J.P. Trinkaus Anniversary Volume 1989 (in press).
A. M. Turing, The chemical basis of morphogenesis, Phil. Trans. Roy. Soc. Lond. B237, 37–72 (1952).
L. Wolpert, Positional information and the spatial pattern of cellular differentiation, J. Theor. Biol. 25, 1–47 (1969).
L. Wolpert, Positional information and pattern formation, Phil. Trans. Roy. Soc. Lond. B295, 441–450 (1981).
L. Wolpert and A. Hornbruch, Double anterior chick limb buds and models for cartilage rudiment specification, Development 109, 961–966 (1990).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1991 Springer Science+Business Media New York
About this chapter
Cite this chapter
Maini, P. (1991). A Comparison of Reaction Diffusion and Mechanochemical Models for Limb Development. In: Hinchliffe, J.R., Hurle, J.M., Summerbell, D. (eds) Developmental Patterning of the Vertebrate Limb. NATO ASI Series, vol 205. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3310-8_23
Download citation
DOI: https://doi.org/10.1007/978-1-4615-3310-8_23
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-6457-3
Online ISBN: 978-1-4615-3310-8
eBook Packages: Springer Book Archive