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A “Packaging” Model of Limb Development

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Book cover Developmental Patterning of the Vertebrate Limb

Part of the book series: NATO ASI Series ((NSSA,volume 205))

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Abstract

This model is based on a hypothesis about the early separation of chondrogenic and non-chondrogenic subpopulations of cells in the limb bud (LB). It is proposed that there exists a morphogenetic mechanism leading to “packaging” of the chondrogenic subpopulation of cells into a properly arranged non-chondrogenic subpopulation of cells during the formation of every skeletal element, This model makes use of several facts and ideas discovered/proposed earlier.

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References

  • Cairns. J. M., (1975). The function of the ectodermal apical ridge and distinctive characteristics of adjacent distal mesoderm in the avian wing bud. J. Embryol. exp. Morph. 34: 155–169.

    PubMed  CAS  Google Scholar 

  • Connelly, T. G., and Bookstein, F. L., (1983). Method for 3-dimensional analysis of patterns of thymidine labelling in regenerating and developing limbs. In “Limb Development and Regeneration. Part A” New York: Alan R. Liss Inc. pp 525–536.

    Google Scholar 

  • Kosher, R. A., Savage, M. P.. and Chan S-C., (1979). In vitro studies on the morphogenesis and differentiation of the mesoderm subjacent to the apical ectodermal ridge of the embryonic chick limb bud. J. Embryo]. exp. Morph. 50: 75–97.

    CAS  Google Scholar 

  • Kwasigroch, T. E., and Kochar. D. M., (1975). Locomotory behaviour of limb bud cells. Exptl. Cell Res. 95: 269–278.

    Article  PubMed  CAS  Google Scholar 

  • Steinberg, M. S., (1963). Reconstruction of tissues by dissociated cells. Science. 141: 401–411.

    Article  PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Koltzov Institute of Developmental Biology, USSR Academy of Science, Moscow, USSR

    Sergei L. Znoiko

Authors
  1. Sergei L. Znoiko
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Editor information

Editors and Affiliations

  1. University College of Wales, Aberystwyth, Wales, UK

    J. Richard Hinchliffe

  2. University of Cantabria, Santander, Spain

    Juan M. Hurle

  3. National Institute for Medical Research, London, UK

    Dennis Summerbell

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© 1991 Springer Science+Business Media New York

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Znoiko, S.L. (1991). A “Packaging” Model of Limb Development. In: Hinchliffe, J.R., Hurle, J.M., Summerbell, D. (eds) Developmental Patterning of the Vertebrate Limb. NATO ASI Series, vol 205. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3310-8_35

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  • DOI: https://doi.org/10.1007/978-1-4615-3310-8_35

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6457-3

  • Online ISBN: 978-1-4615-3310-8

  • eBook Packages: Springer Book Archive

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