Abstract
Hyaluronan is a ubiquitous component of the extracellular matrices in which cells migrate and proliferate during embryonic development (reviewed in Toole, 1981). Its physical and chemical properties contribute to an extracellular milieu which is important both to the structural integrity of embryonic tissues and to the morphogenetic processes that take place within them. One way in which hyaluronan participates in tissue structure arises from its ability to form meshworks that exert osmotic pressure (Comper and Laurent, 1978; Meyer, 1983). The resultant swelling pressure within the tissue can lead to separation of cellular or fibrous structures or deformation of the tissue, possibly facilitating cell and tissue movements (Toole, 1981; Morris-Wiman and Brinkley, 1990). In addition, some embryonic cells exhibit large, hyaluronan-dependent, pericellular coats (Knudson and Toole, 1985) that may influence cell-cell adhesion (Underhill and Toole, 1981; Knudson, 1990a), cell-substratum adhesion (Barnhart et al., 1979), cell proliferation (Brecht et al., 1986), migration (Turley et al., 1985; Schor et al., 1989) or differentiation (Kujawa et al., 1986).
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Aono, H., and Ide, H., 1988, A gradient of responsiveness to the growth-promoting activity of ZPA (zone of polarizing activity) in the chick limb bud, Develop. Biol. 128:136–141.
Aruffo, A., Stamenkovic, I., Melnick, M., Underhill, C.B., and Seed, B., 1990, CD44 is the principal cell surface receptor for hyaluronate, Cell 61:1303–1313.
Banerjee, S.D., and Toole, B.P., 1990, Monoclonal antibodies to chick embryo hyaluronan-binding proteins, submitted for publication.
Barnhart, B.J., Cox, S.H., and Kraemer, P.M., 1979, Detachment variants of Chinese hamster cells. Hyaluronic acid as a modulator of cell detachment, Exp. Cell Res. 119:327–332.
Bee, J.A., and von der Mark, K., 1990, An analysis of chick limb bud intercellular adhesion underlying the establishment of cartilage aggregates in suspension culture, J. Cell Sci. 96:527–536.
Bell, K.M., and McLachlan, J.C., 1985, Stimulation of division in mouse 3T3 cells by coculture with embryonic chick limb tissue, J. Embryol. Exp. Morphol. 86:219–226.
Brecht, M., Mayer, U., Schlosser, E., and Prehm, P., 1986, Increased hyaluronate synthesis is required for fibroblast detachment and mitosis, Biochem. J. 239:445–450.
Comper, W.D., and Laurent, T.C., 1978, Physiological function of connective tissue polysaccharides, Physiol. Rev. 58:255–315.
Crossman, M.V., and Mason, R.M., 1990, Purification and characterization of a hyaluronan-binding protein from rat chondrosarcoma, Biochem. J. 266:399–406.
Goldberg, R.L., and Toole, B.P., 1984, Pericellular coat of chick embryo chondrocytes: structural role of hyaluronate, J. Cell Biol. 99:2114–2122.
Green, S.J., Tarone, G., and Underhill, C.B., 1988, Aggregation of macrophages and fibroblasts is inhibited by a monoclonal antibody to the hyaluronate receptor, Exp. Cell Res. 178:224–232.
Hascall, V.C., and Hascall, G.K., 1981, Proteoglycans, in: Cell Biology of Extracellular Matrix, E.D. Hay, ed., Plenum, New York, pp 39–63.
Hurle, J.M., Ganan, Y., and Macias, D., 1989, Experimental analysis of the in vivo chondrogenic potential of the interdigital mesenchyme of the chick leg bud subjected to local ectodermal removal, Develop. Biol. 132:368–374.
Knudsen, K.A., Myers, L., and McElwee, S.A., 1990, A role for the Cat’-dependent adhesion molecule, N-cadherin, in myoblast interaction during myogenesis, Exp. Cell Res. 188:175–184.
Knudson, C.B., 1990a, Cell-cell adhesion of limb bud mesoderm mediated by hyaluronan, Development, in press.
Knudson, C.B., 1990b, Role of hyaluronan in the assembly of chondrocyte pericellular matrix, submitted for publication.
Knudson, C.B., and Knudson, W., 1990, Similar epithelial-stromal interactions in the regulation of hyaluronate production during limb morphogenesis and tumor invasion, Cancer Lett. 52:113–122.
Knudson, C.B., and Toole, B.P., 1985, Changes in the pericellular matrix during differentiation of limb bud mesoderm, Develop. Biol. 112:308–318
Knudson, C.B., and Toole, B.P., 1987, Hyaluronate-cell interactions during differentiation of chick embryo limb mesoderm, Develop. Biol. 124:82–90
Knudson, C.B., and Toole, B.P., 1988, Epithelial-mesenchymal interaction in the regulation of hyaluronate production during limb development, Biochem. Intl. 17:735–745.
Knudson, W., Biswas, C., Li, X-Q., Nemec, R.E., and Toole, B.P., 1989, The role and regulation of tumour-associated hyaluronan, Ciba Found. Symp. 143:150–169.
Kujawa, M.J., Pechak, D.G., Fiszman, M.Y., and Caplan, A.I., 1986, Hyaluronic acid bonded to cell culture surfaces inhibits the program of myogenesis, Develop. Biol. 113:10–16.
Laurent, T.C., Fraser, J.R.E., Pertoft, H., and Smedsrod, B., 1986, Binding of hyaluronate and chondroitin sulphate to liver endothelial cells, Biochem. J. 234:653–658.
Lesley, J., Schulte, R., and Hyman, R., 1990, Binding of hyaluronic acid to lymphoid cell lines is inhibited by monoclonal antibodies against Pgpl, Exp. Cell Res. 187:224–233.
McCarthy, M.T., and Toole, B.P., 1989, Membrane-associated hyaluronatebinding activity of chondrosarcoma chondrocytes, J. Cell. Physiol. 141:191–202.
McGary, C.T., Raja, R.H., and Weigel, P.H., 1989, Endocytosis of hyaluronic acid by rat liver endothelial cells. Evidence for receptor recycling, Biochem. J. 257:875–884.
McGuire, P.G., Castellot, J.J., and Orkin, R.W., 1987, Size-dependent hyaluronate degradation by cultured cells, J. Cell. Physiol. 133:267–276
Meyer, F.A., 1983, Macromolecular basis of globular protein exclusion and of swelling pressure in loose connective tissue (umbilical cord)Biochim. Biophys. Acta 755:388–399.
Miyake, K., Underhill, C.B., Lesley, J., and Kincade, P.W., 1990, Hyaluronate can function as a cell adhesion molecule and CD44 participates in hyaluronate recognition, J. Exp. Med. 172:69–75.
Morris-Wiman, J., and Brinkley, L.L., 1990, Changes in mesenchymal cell and hyaluronate distribution correlate with in vivo elevation of the mouse mesencephalic neural folds, Anat. Rec. 226:383–395.
Munaim, S.I., Klagsbrun, M., and Toole, B.P., 1988, Developmental changes in fibroblast growth factor in the chicken embryo limb bud, Proc. Natl. Acad. Sci. USA 85:8091–8093.
Munaim, S.I., Klagsbrun, M., and Toole, B.P., 1990, Hyaluronan-dependent pericellular coats of chick embryo limb mesodermal cells: induction by basic fibroblast growth factor, Develop. Biol. in press.
Orkin, R.W., Knudson, W., and Toole, B.P., 1985, Loss of hyaluronate-dependent coat during myoblast fusion, Develop. Biol. 107:527–530.
Sanderson, R.D., Fitch, J.M., Linsenmayer, T.F., and Mayne, R., 1986, Fibroblasts promote the formation of a continuous basal lamina during myogenesis in vitroJ. Cell Biol. 102:740–747.
Schor, S.L., Schor, A.M., Grey, A.M., Chen, J., Rushton, G., Grant, M.E., and Ellis, I., 1989, Mechanism of action of the migration stimulating factor produced by fetal and cancer patient fibroblasts: Effect on hyaluronic acid synthesis, In Vitro Cell Develop. Biol. 25:737–746.
Seed, J., Olwin, B.B., and Hauschka, S.D., 1988, Fibroblast growth factor levels in the whole embryo and limb bud during chick development Develop. Biol. 128:50–57.
Singley, C.T., and Solursh, M., 1981, The spatial distribution of hyaluronic acid and mesenchymal condensation in the embryonic chick wing Develop. Biol. 84:102–120.
Smith, J.C., 1989, Mesoderm induction and mesoderm-inducing factors in early amphibian development Development 105:665–677.
Solursh, M., 1990, The role of extracellular matrix molecules in early limb development Seminars Develop. Biol. 1:45–53.
Solursh, M., Ahrens, P.B., and Reiter, R.S., 1978, A tissue culture analysis of the steps in limb chondrogenesis In Vitro 14:51–61.
Solursh, M., Singley, C.T., and Reiter, R.S., 1981, The influence of epithelia on cartilage and loose connective tissue formation by limb mesenchyme cultures Develop. Biol. 86:471–482.
Tengblad, A., 1981, A comparative study of the binding of cartilage link protein and the hyaluronate-binding region of the cartilage proteoglycan to hyaluronate-substituted Sepharose gel Biochem. J. 199:297–305.
Toole, B.P., 1981, Glycosaminoglycans inmorphogenesis, in Cell Biology of Extracellular Matrix E.D. Hay, ed., Plenum, New York, pp. 259–294.
Toole, B.P., 1990, Hyaluronan and its binding proteins, the hyaladherins Current Opinion Cell. Biol. 2: in press.
Toole, B.P. Munaim, S.I., Welles, S., and Knudson, C.B., 1989, Hyaluronatecell interactions and growth factor regulation of hyaluronate synthesis during limb development, Ciba Found. Symp. 143:138–149.
Turley, E.A., Bowman, P., and Kytryk, M.A., 1985, Effects of hyaluronate and hyaluronate binding proteins on cell motile and contact behavior J. Cell Sci. 78:133–145.
Turner, R., Banerjee, S.D., and Toole, B.P., 1990, Role of hyaluronanbinding protein in chondrogenesis, submitted for publication.
Underhill, C.B., 1982, Interaction of hyaluronate with the surface of simian virus 40-transformed 3T3 cells: Aggregation and binding studies, J. Cell Sci. 56:177–189.
Underhill, C.B., and Toole, B.P., 1981, Receptors for hyaluronate on the surfaces of parent and virus-transformed cell lines. Binding and aggregation studies Exp. Cell Res. 131:419–423.
Underhill, C.B., Green, S.J., Comoglio, P.M., and Tarone, G., 1987, The hyaluronate receptor is identical to a glycoprotein of M. 85,000 (gp85) as shown by a monoclonal antibody that interferes with binding activity J. Biol. Chem. 262:13142–13146.
Welles, S., and Toole, B.P., 1987, Muscle fibroblast extracellular matrix modulates myoblast differentiation in vitro, J. Cell Biol. 105:139a (abstract).
Whitman, M., and Melton, D.A., 1989, Growth factors in early embryogenesis, Annu. Rev Cell. Biol. 5:93–117.
Yu, Q., Banerjee, S.D., and Toole, B.P., 1990, Inhibition of pericellular coat production by antibody to hyaluronan-binding protein, submitted for publication.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1991 Springer Science+Business Media New York
About this chapter
Cite this chapter
Toole, B., Banerjee, S., Turner, R., Munaim, S., Knudson, C. (1991). Hyaluronan-Cell Interactions in Limb Development. In: Hinchliffe, J.R., Hurle, J.M., Summerbell, D. (eds) Developmental Patterning of the Vertebrate Limb. NATO ASI Series, vol 205. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3310-8_30
Download citation
DOI: https://doi.org/10.1007/978-1-4615-3310-8_30
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-6457-3
Online ISBN: 978-1-4615-3310-8
eBook Packages: Springer Book Archive